Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease

Abramson, Jerome L.; Hooper, W. Craig; Jones, Dean P.; Ashfaq, Salman; Rhodes, Steven D.; Weintraub, William S.; Harrison, David G.; Quyyumi, Arshed A.; Vaccarino, Viola

doi:10.1016/j.atherosclerosis.2004.08.007

Cited by 120 publications

(94 citation statements)

References 28 publications

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“…Oxidative stress may be a determinant of CRP concentrations and may promote the proatherosclerotic inflammatory process (34 ). We have previously demonstrated a correlation between CRP and oxidative stress markers (MDA, CDE) in healthy children and adolescents, as well as between CRP, MDA, and CDE with abdominal obesity, but not with generalized obesity (10 ).…”

Section: Discussionmentioning

confidence: 93%

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children

et al. 2008

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Background: The association of changes in oxidative and proinflammatory states with vascular function after diet and exercise intervention among obese children has not been previously explored. Methods: In this 6-week diet and exercise intervention study in 35 obese children, age 12 to 18 years, we evaluated the relationship between changes in anthropometric indices, measures of insulin resistance, C-reactive protein (CRP), oxidized LDL (ox-LDL), and oxidative stress markers with changes in carotid intima-media thickness (C-IMT) and flow mediated dilation (FMD) of the brachial artery. Results: At the end of the study, body mass index (BMI), waist circumference, and percentage body fat were decreased (P <0.05), but participants remained overweight (BMI ≥ 95th percentile). Although FMD improved (P <0.05), the improvement in C-IMT did not reach statistical significance. The changes in BMI, waist circumference, fat mass, ox-LDL, malondialdehyde (MDA), CRP, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) had an inverse correlation with the changes in mean FMD after adjustment for age and sex, with the highest correlations documented for ox-LDL, CRP, and WC. The age- and sex-adjusted changes in ox-LDL, waist circumference, CRP, MDA, and body fat mass had the highest correlations with changes in C-IMT. Conclusions: Our findings suggest that a common inflammatory stress condition associated with childhood obesity, notably with abdominal fat deposition, may play a role in the development of the earliest stages of proatherosclerotic inflammatory processes and subsequent vascular dysfunction. These changes might be partially reversible by short-term diet and exercise intervention, even if patients do not reach ideal body weight.

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Section: Discussionmentioning

confidence: 93%

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children

et al. 2008

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“…The same patient group has also been shown to have increased inflammatory response caused by the oxidative stress. Abramson et al presented data indicating a significant relation between the level of oxidative stress and level of inflammation as measured by high sensitivity Creactive protein (hsCRP) [10].…”

Section: Introductionmentioning

confidence: 99%

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

Alehagen

Aaseth

2015

Journal of Trace Elements in Medicine and Biology

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“…PCT is a marker suggested for sepsis specifically while CRP was more as inflammatory marker. (18,19). Patients included in our study were diagnosed with SIRS and they may not necessarily had sepsis.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of Tocotrienol Rich Fraction and Αlpha Tocoferol with Combination of Vitamin C in The Management of Systemic Inflammatory Response Syndrome (SIRS)

Ye¹,

Rahman²,

Mz³

et al. 2017

JSA

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The pathophysiology of systemic inflammatory response syndrome (SIRS) had been described to involve various strong oxidative reactions affecting the status and progress of the patients. Antioxidant therapy had been suggested in many studies involving SIRS management. The objective of this study was to compare the role of vitamin E Tocotrienol and vitamin E Tocopherol combined with vitamin C as antioxidant therapy in the management of critically ill patients diagnosed with SIRS, admitted to the intensive care unit and high dependency wards of Universiti Kebangsaan Malaysia Medical Centre (UKMMC). It was a single blind randomized clinical trial with a total of 72 patients in which 44.4% Malays, 34.7% Chinese, 19.4% Indians and 1.4% others with 59.7% males and 40.3% females were recruited. Patients in TRI E group received Tocotrienol with Vitamin C while TOCO group received Tocopherol with Vitamin C and a control group did not receive any antioxidant. The clinical parameters (heart rate, respiratory rate, systolic blood pressure) showed improvements with significant difference at the end of study (post-intervention) as compared to admission (pre-intervention).Whereas, the sepsis (temperature, PCT, CRP and WBC) and oxidative stress (8-OHdG/Creatinine) parameters showed improvements with significant difference at the end of study (post-intervention) as compared to admission (pre-intervention). The TRI E group showed obvious improvement in clinical, sepsis and oxidative stress parameters, as compared to TOCO and control groups. This study showed that Vitamin E Tocotrienol and Vitamin E Tocopherol in combination with Vitamin C demonstrated significant improvement in the clinical and laboratory parameters during the management of SIRS. Therefore, Vitamin E in combination with Vitamin C had therapeutic benefits in the treatment of critically ill patients with SIRS.

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Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease

Cited by 120 publications

References 28 publications

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children

Association of Changes in Oxidative and Proinflammatory States with Changes in Vascular Function after a Lifestyle Modification Trial Among Obese Children

Selenium and coenzyme Q10 interrelationship in cardiovascular diseases – A clinician's point of view

The Effectiveness of Tocotrienol Rich Fraction and Αlpha Tocoferol with Combination of Vitamin C in The Management of Systemic Inflammatory Response Syndrome (SIRS)

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