Association between omentin-1 and major cardiovascular events after lower extremity endovascular revascularization in diabetic patients: a prospective cohort study

Biscetti, Federico; Nardella, Elisabetta; Rando, Maria Margherita; Cecchini, Andrea Leonardo; Angelini, Flavia; Cina, Alessandro; Iezzi, Roberto; Filipponi, Marco; Santoliquido, Angelo; Pitocco, Dario; Landolfi, Raffaele; Flex, Andrea

doi:10.21203/rs.3.rs-30048/v2

Cited by 4 publications

(7 citation statements)

References 30 publications

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“…Previous meta-analyses demonstrated that serum omentin-1 concentration was independently and negatively associated with CAD and reduced in obese individuals (Agasthi et al, 2015;Arab et al, 2020). Researchers who performed studies on patients with type 2 diabetes mellitus suggest that decreased omentin-1 level may be an independent risk factor for arteriosclerosis and carotid plaque formation in these patients (Yoo et al, 2011;Nishimura et al, 2019;Biscetti et al, 2020). Low omentin-1 serum concentration was associated with acute coronary syndrome, stable angina and ischemic stroke (Shibata et al, 2011;Zhong et al, 2011;Yue et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

et al. 2021

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Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.

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Section: Discussionmentioning

confidence: 99%

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

et al. 2021

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“…All patients over 18 years of age with a diagnosis of T2DM present for a least one year, an Ankle/Brachial Index (ABI) of less than 80, lower limb stenosis greater than 50% documented by Ultrasound Color Doppler (US), category 4 or 5 of PAD in accord to Rutherford classi cation, presence of CLTI as previously de ned (17,34,35), and the need for endovascular treatment, were included in the study.…”

Section: Study Population and Clinical Assessmentmentioning

confidence: 99%

“…Lower-limb endovascular revascularization and follow-up after the procedure Lower-limb revascularization through balloon angioplasty and/or stenting were performed as previously described (17,34,35). Revascularization was considered successful if the residual stenosis of the treated arterial vessel was less than 30%.…”

Section: Study Population and Clinical Assessmentmentioning

confidence: 99%

Serum high mobility group box-1 levels associated with cardiovascular events after lower extremity revascularization: a prospective study of a diabetic population

Rando

Biscetti

Cecchini

et al. 2022

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Background: Peripheral arterial disease (PAD) is one of the most disabling cardiovascular complications of type 2 diabetes mellitus and is indeed associated with a high risk of cardiovascular and limb adverse events. High mobility group box-1 (HMGB-1) is a nuclear protein involved in the inflammatory response that acts as a pro-inflammatory cytokine when released into the extracellular space. HMBG-1 is associated with PAD in diabetic patients.The aim of this study was to evaluate the association between serum HMGB-1 levels and major adverse cardiovascular events (MACE) and major adverse limb events (MALE) after lower-extremity endovascular revascularization (LER) in a group of diabetic patients with chronic limb-threatening ischemia (CLTI).Methods: we conducted a prospective observational study of 201 diabetic patients with PAD and CLTI requiring LER. Baseline serum HMGB-1 levels were determined before endovascular procedure. Data on cardiovascular and limb outcomes were collected in a 12-month follow-up. Results: During the follow-up period, 81 cases of MACE and 93 cases of MALE occurred. Patients who subsequently developed MACE and MALE had higher serum HMGB-1 levels. Specifically, 7.5 ng/mL vs 4.9 ng/mL (p < 0.01) for MACE and 7.2 ng/mL vs 4.8 ng/mL (p < 0.01) for MALE. After adjusting for traditional cardiovascular risk factors, the association between serum HMGB-1 levels and cardiovascular outcomes remained significant in multivariate analysis. In our receiver operating characteristic (ROC) curve analysis, serum HMGB-1 levels were a good predictor of MACE incidence (area under the curve [AUC] = 0.78) and MALE incidence (AUC = 0.75).Conclusions: This study demonstrates that serum HMGB-1 levels are associated with the incidence of MACE and MALE after LER in diabetic populations with PAD and CLTI.

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“…They underwent also a detailed clinical examination, an ECG at rest, an ultrasound of carotid arteries and cerebral CT-scan to assess the presence of acute cerebrovascular disease, such as cerebral infarction. The diagnosis of T2DM was con rmed according to previous studies [24][25][26][27][28][29]. Blood hypertension was de ned as a systolic blood pressure ≥ 130 mmHg and a diastolic blood pressure ≥ 85 mmHg or presence of active anti-hypertensive treatment.…”

Section: Study Populationmentioning

confidence: 99%

Association Between Carotid Plaque Vulnerability and High Mobility Group Box-1 Serum Levels in a Diabetic Population

Biscetti

Tinelli

Rando

et al. 2021

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Background: Carotid atherosclerosis represents one of the complications of diabetes mellitus. In particular, plaque instability contributes to disease progression and stroke incidence. High mobility group box-1 (HMGB1) is a nuclear protein involved in promotion and progression of atherosclerosis and cardiovascular diseases. The aim of this study was to analyze the relationship between HMGB1 serum levels, main inflammatory cytokines, the presence of internal carotid stenosis and unstable plaque in a diabetic population.Research Design and Methods: We studied 873 diabetic patients, including 347 patients with internal carotid artery stenosis (ICAS) who underwent carotid endarterectomy and 526 diabetic patients without internal carotid artery stenosis (WICAS). At baseline, HMGB1 and the main inflammatory cytokines serum levels were evaluated. For ICAS patients, the histological features of carotid plaque were also collected to differentiate them in patients with stable or unstable atherosclerotic lesions.Results: We found that HMGB1 serum levels, osteoprotegerin, high-sensitivity C-reactive protein, tumor necrosis factor-alpha and interleukin-6, were significantly higher in diabetic ICAS patients compared to diabetic WICAS patients. Among ICAS patients, individuals with unstable plaque had higher levels of these cytokines, compared to patients with stable plaque. A multivariable stepwise logistic regression analysis showed that HMGB1 and osteoprotegerin remained independently associated with unstable plaque in ICAS patients.Conclusions: The present study demonstrated that HMGB1 is an independent risk factor for carotid plaque vulnerability in an Italian population with diabetes mellitus, representing a promising biomarker of carotid plaque instability and a possible molecular target to treat unstable carotid plaques and to prevent stroke.

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Association between omentin-1 and major cardiovascular events after lower extremity endovascular revascularization in diabetic patients: a prospective cohort study

Cited by 4 publications

References 30 publications

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients

Serum high mobility group box-1 levels associated with cardiovascular events after lower extremity revascularization: a prospective study of a diabetic population

Association Between Carotid Plaque Vulnerability and High Mobility Group Box-1 Serum Levels in a Diabetic Population

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