Association between oxidative balance score and kidney stone in United States adults: analysis from NHANES 2007-2018

Abstract

Purpose: To investigate the relationship between the Oxidative Balance Score (OBS) and kidney stone risk using NHANES 2007-2018 data, and to explore potential mechanisms and population-specific effects.Materials and methods: Data from the NHANES 2007-2018 were analyzed. OBS was calculated based on 16 dietary components and 4 lifestyle components. Multivariate logistic regression was employed to investigate the relationship between OBS and kidney stone. Further stratified analyses were conducted to examine the associations across different subgroups.Results: A total of 19,799 participants were included in the study. There was a consistent inverse association between OBS and the risk of kidney stones (OR = 0.97; 95% CI: 0.96–0.99). After dividing the participants into quartiles based on OBS, compared to the lowest quartile of OBS, the risk of kidney stones in the highest quartile of OBS was reduced by 33% (95% CI 0.50–0.89; p = 0.002). This association was consistent across both dietary and lifestyle OBS scores. The protective effect of OBS was notably pronounced among Non-Hispanic white and Other race groups, and among individuals with a higher level of education. However, the association was not significant among individuals with diabetes.Conclusion: A higher OBS, indicating a balance skewed towards antioxidants, is associated with a reduced risk of kidney stones, especially among specific population subgroups. These findings underscore the potential role of oxidative balance in kidney stone pathogenesis and highlight the importance of considering individual and population-specific factors in future research and preventive strategies.

Cymbopogon proximus and Petroselinum crispum seed ethanolic extract/Gum Arabic nanogel emulsion: Preventing ethylene glycol and ammonium chloride-induced urolithiasis in rats

“…Furthermore, vitamin B12 exhibited antioxidant properties, protecting cells and DNA from reactive oxygen species-induced damage, inversely correlating with the risk of kidney stone development [ 75 ]. Additionally, Ke et al (2023) [ 76 ], emphasized the association between a higher Oxidative Balance Score, indicative of an antioxidant-skewed balance, and a reduced risk of kidney stones, particularly among specific population subgroups.…”

Association of oxidative balance score with hearing loss and tinnitus: NHANES 1999–2018

“…The sample design and data Research Topic were overseen by the National Center for Health Statistics (NCHS), while the methodology for data Research Topic, as well as subsequent data processing and review, were managed by the USDA Food Survey Research Group (FSRG). The determination of OBS was based on earlier studies (34)(35)(36)(37)(38)(39). OBS was computed through the evaluation of 16 dietary and 4 lifestyle components, comprising 15 antioxidants and 5 pro-oxidants.…”

“…The oxidative balance score (OBS), a tool evaluating the balance between antioxidant and pro-oxidative components across diverse dietary and lifestyle factors, has emerged as a promising metric ( 34 ). Recent studies have associated OBS with various diseases, such as depression ( 35 ), cardiovascular disease ( 36 ), kidney stones ( 37 ), and non-alcoholic fatty liver disease ( 38 ), demonstrating that a higher OBS is linked to a lower risk of these diseases. However, there are currently no studies on the correlation between OBS and hearing loss as well as tinnitus.…”

Association of the oxidative balance score with sarcopenia among young and middle-aged adults: findings from NHANES 2011–2018

“…To evaluate the roles of multiple diets and lifestyles on the overall oxidative/antioxidant system, the Oxidative Balance Score (OBS) has been developed to measure one's general exposure to oxidants and antioxidants ( 14 ). Studies have demonstrated that a higher OBS reflects increased protection against a range of diseases—including kidney disease ( 15 ), diabetes ( 16 ), non-alcoholic fatty liver disease ( 17 ), and even depression ( 18 ). However, few studies in the literature have reviewed the correlation between sarcopenia and OBS.…”