Association between p53 Codon 72 (Arg72Pro) Polymorphism and Primary Open-Angle Glaucoma in Iranian Patients

Neámatzadeh, Hossein; Soleimanizad, Reza; Zare-Shehneh, Masoud; Gharibi, Saba; Shekari, Abolfazl; Rahimzadeh, Amir Bahman

doi:10.6091/ibj.1379.2014

Cited by 11 publications

(2 citation statements)

References 20 publications

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“…Blanco-Marchite et al [103] showed that the TP53 p.R72P polymorphism acts as a glaucoma risk factor in Spanish patients and suggested a genetic interplay between TP53 and WD repeat domain 36 (WDR36) variants in POAG susceptibility. Furthermore, TP53 was found to be associated with POAG in a cohort of 65 unrelated POAG patients in Iran [104] and with PACG in a North Indian patient cohort [105]. In a meta-analysis with subgroup analyses controlling for ethnicity, the association between the TP53 codon 72 polymorphism and POAG risk was detected in Asian populations, but not in Caucasian populations [106].…”

Section: Tp53mentioning

confidence: 96%

The Role of Mitophagy in Glaucomatous Neurodegeneration

Stavropoulos,

Grewal,

Petriti

et al. 2023

Cells

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This review aims to provide a better understanding of the emerging role of mitophagy in glaucomatous neurodegeneration, which is the primary cause of irreversible blindness worldwide. Increasing evidence from genetic and other experimental studies suggests that mitophagy-related genes are implicated in the pathogenesis of glaucoma in various populations. The association between polymorphisms in these genes and increased risk of glaucoma is presented. Reduction in intraocular pressure (IOP) is currently the only modifiable risk factor for glaucoma, while clinical trials highlight the inadequacy of IOP-lowering therapeutic approaches to prevent sight loss in many glaucoma patients. Mitochondrial dysfunction is thought to increase the susceptibility of retinal ganglion cells (RGCs) to other risk factors and is implicated in glaucomatous degeneration. Mitophagy holds a vital role in mitochondrial quality control processes, and the current review explores the mitophagy-related pathways which may be linked to glaucoma and their therapeutic potential.

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Section: Tp53mentioning

confidence: 96%

The Role of Mitophagy in Glaucomatous Neurodegeneration

Stavropoulos,

Grewal,

Petriti

et al. 2023

Cells

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“…Fan et al ( 218 ) confirmed the role of p53 variants in POAG, at least in the Chinese population. Several studies have indicated that p53 codon 72 (Pro/Pro vs. Arg/Pro + Pro/Pro) polymorphisms and the introductions of three 16-bp insertions (insertion vs. deletion) possibly contribute to individual susceptibility to POAG, at least in Spain and Iran, and to an increased risk of developing PACG in North India ( 219 – 223 ). Additionally, Wiggs et al ( 224 ) demonstrated that the p53 codon 72 Pro/Pro genotype was a potential risk factor for early paracentral visual field defects in Caucasians with POAG.…”

Section: Regulators Of Apoptotic Pathway In Glaucomamentioning

confidence: 99%

Apoptosis in glaucoma: A new direction for the treatment of glaucoma (Review)

Xia,

Zhang

2024

Mol Med Rep

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Glaucoma is a group of progressive optic nerve disorders characterized by the loss of retinal ganglion cells, a thinner retinal nerve fibre layer and cupping of the optic disk. Apoptosis is a physiological cell death process regulated by genes and plays a crucial role in maintaining tissue homeostasis, ensuring the natural development and immune defence of organisms. Apoptosis has been associated with glaucoma and inhibiting apoptosis by activating phosphatidylinositol 3-kinase-protein kinase B or other medicines can rescue pathological changes in glaucoma. Due to the complex crosstalk of apoptosis pathways, the pathophysiological mechanism of apoptosis in glaucoma needs to be fully elucidated. The present review aimed to discuss the mechanism of cell apoptosis in glaucoma, improve the understanding of the pathophysiology of glaucoma, summarize new directions for the treatment of glaucoma and lay the foundation for new treatment strategies for glaucoma.

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