Association between PAI-1 4G/5G polymorphism and diabetic nephropathy: a meta-analysis in the Chinese population

Gao, Weijie; Guo, Yingbo; Bai, Yu; Ding, Xinyu; Yan, Ye; Wu, Zhenqi

doi:10.1007/s11255-016-1333-9

Cited by 10 publications

(10 citation statements)

References 9 publications

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“…Concerning the association with DN risk, our results indicated a strong linkage between SERPINE1 4G polymorphism and DN risk in the overall and Asian populations. This is consistent with former studies [ 25 , 71 ] and further implies that heterogeneity is affected by ethnicity. Moreover, insufficient genetic data in mix ethnicities could limit the possibility of further discussion regarding this population, which to a considerable extent could alter the overall analyses.…”

Section: Discussionsupporting

confidence: 93%

The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

Chen

Zhai

Wang³

et al. 2021

BMC Endocr Disord

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Background The serine protease inhibitor-1 (SERPINE1) rs1799889 single nucleotide polymorphism (SNP) has been constantly associated with diabetes mellitus (DM) and its vascular complications. The aim of this meta-analysis was to evaluate this association with combined evidences. Methods The systematic search was performed for studies published up to March 2021 which assess the associations between SERPINE1 rs1799889 SNP and the risks of DM, diabetic retinopathy (DR), diabetic cardiovascular disease (CVD) and diabetic nephropathy (DN). Only case-control studies were identified, and the linkage between SERPINE1 rs1799889 polymorphism and diabetic vascular risks were evaluated using genetic models. Results 51 comparisons were enrolled. The results revealed a significant association with diabetes risk in overall population (allelic: OR = 1.34, 95 % CI = 1.14–1.57, homozygous: OR = 1.66, 95 % CI = 1.23–2.14, heterozygous: OR = 1.35, 95 % CI = 1.08–1.69, dominant: OR = 1.49, 95 % CI = 1.18–1.88, recessive: OR = 1.30, 95 % CI = 1.06–1.59) as well as in Asian descents (allelic: OR = 1.45, 95 % CI = 1.16–1.82, homozygous: OR = 1.88, 95 % CI = 1.29–2.75, heterozygous: OR = 1.47, 95 % CI = 1.08-2.00, dominant: OR = 1.64, 95 % CI = 1.21–2.24, recessive: OR = 1.46, 95 % CI = 1.09–1.96). A significant association was observed with DR risk (homozygous: OR = 1.25, 95 % CI = 1.01–1.56, recessive: OR = 1.20, 95 % CI = 1.01–1.43) for overall population, as for the European subgroup (homozygous: OR = 1.32, 95 % CI = 1.02–1.72, recessive: OR = 1.38, 95 % CI = 1.11–1.71). A significant association were shown with DN risk for overall population (allelic: OR = 1.48, 95 % CI = 1.15–1.90, homozygous: OR = 1.92, 95 % CI = 1.26–2.95, dominant: OR = 1.41, 95 % CI = 1.01–1.97, recessive: OR = 1.78, 95 % CI = 1.27–2.51) and for Asian subgroup (allelic: OR = 1.70, 95 % CI = 1.17–2.47, homozygous: OR = 2.46, 95 % CI = 1.30–4.66, recessive: OR = 2.24, 95 % CI = 1.40–3.59) after ethnicity stratification. No obvious association was implied with overall diabetic CVD risk in any genetic models, or after ethnicity stratification. Conclusions SERPINE1 rs1799889 4G polymorphism may outstand for serving as a genetic synergistic factor in overall DM and DN populations, positively for individuals with Asian descent. The association of SERPINE1 rs1799889 SNP and DR or diabetic CVD risks was not revealed.

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Section: Discussionsupporting

confidence: 93%

The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

Chen

Zhai

Wang³

et al. 2021

BMC Endocr Disord

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“…Chang et al (4) stated that the homozygous 5G allele in the PAI gene rs1799889 polymorphism was defined as a protective factor in the development of diabetes in obese diabetic and insulin resistance patients. In a meta-analysis study, it was shown that the PAI-1 4G allele could be a risk allele for DN sensibility in the Chinese population (18). Unlike our results, Chen et al (19) reported that the PAI-1 rs1799889 polymorphism was not associated with T2 DM risk.…”

Section: Discussioncontrasting

confidence: 94%

The role of rs1799889 genetic variation in Type 2 diabetes and Diabetic Nephropathy risk

Bayramoğlu¹,

Bayramoğlu²,

Güler³

2020

Erciyes Med J

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Type 2 diabetes mellitus (T2 DM) represents a complex metabolic disease with genetic heterogeneity and increasing worldwide prevalence. One of the candidate genes associated with T2 DM and diabetic nephropathy (DN) is the plasminogen activator inhibitor-1 (PAI-1) gene. The present research aimed to reveal the polymorphism frequencies of the PAI-1 gene 4G/5G and to investigate the role of this polymorphism in T2 DM and DN development. Materials and Methods: The genomic DNA of the 261 individuals was included in this study. The polymerase chain reaction (PCR) method with 4G and 5G allele-particular primers was used to identify the polymorphism of PAI-1 4G/5G. The PCR products were evaluated using a CCD camera after 2% agarose gel electrophoresis. Results: Although the frequencies of the gene genotypes differed statistically significant between 80 patients and 51 patients with and without DN, respectively, and the control group, no statistically significant difference was detected between those with and without DN. The 5G/5G genotype was found to be significantly higher in the patient group. Conclusion: The findings suggest that there is a significant correlation between variants of the PAI-1 gene and the risk for T2 DM formation.

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“…14 It is advised to enrol enough number of samples to decipher the genotypes frequency of a population: we have enrolled a higher number of healthy females (n = 350) compared to earlier studies. 14 PAI-1 down regulates fibrinolysis and maintains the appropriate plasminogen plasmin ratio. The role of PAI-1 in human osteoporosis is ill defined.…”

Section: Discussionmentioning

confidence: 99%

“…However, reports including healthy subjects from Fujian and Shandong showed a higher prevalence of 5G/5G genotype over wild-type (4G/4G) and heterozygous mutants (4G/5G). 14 It is advised to enrol enough number of samples to decipher the genotypes frequency of a population: we have enrolled a higher number of healthy females (n = 350) compared to earlier studies. 14…”

Section: Discussionmentioning

confidence: 99%

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Role of plasminogen activator inhibitor-1 gene polymorphisms in osteoporosis: A study in Chinese post-menopausal women

Wan

Liu

2018

Eur J Inflamm

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Osteoporosis is a chronic multifactorial disease characterized by deterioration of bone mass and is vulnerable to bone fracture. Plasminogen activator inhibitor-1 (PAI-1) is an important molecule for maintenance of optimum bone mass. Several single-nucleotide polymorphisms (SNPs) in PAI-1 have been reported to alter PAI-1 expression and/ or the translational level. In this report, we explored the possible role of common PAI-1 gene polymorphisms on predisposition to osteoporosis in a Chinese cohort. A total of 364 post-menopausal Chinese women diagnosed of having osteoporosis and 350 healthy females hailing from similar areas were enrolled in this study. Five common SNPs (−844G > A, −6754G/5G, +43G > A, +9785G > A and +11053T > G) were genotyped by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP). Relative expression of PAI-1 mRNA and plasma PAI-1 levels were quantified by reverse transcription polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Prevalence of homozygous mutant (5G/5G) and minor allele (5G) of PAI-1 (−675 4G/5G) polymorphism was significantly more frequent in patients than in healthy controls (5G/5G: P < 0.0001, odds ratio (OR) = 3.18; 5G: P < 0.0001, OR = 1.65). Both plasma PAI-1 and relative mRNA expression levels were significantly lower in patients compared to healthy controls. Interestingly, the quantity of plasma PAI-1 and mRNA expression was correlated with PAI-1 (−675 4G/5G) polymorphism: subjects with 4G/4G genotype had elevated PAI-1 in comparison to homozygous mutant, and displayed lower quantity of PAI-1 protein and mRNA values. PAI-1 (−675 4G/5G) mutant is associated with susceptibility to development of osteoporosis in post-menopausal Chinese women. Furthermore, this variant in the promoter region alters plasma protein levels and relative expression of PAI-1.

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Association between PAI-1 4G/5G polymorphism and diabetic nephropathy: a meta-analysis in the Chinese population

Abstract: This meta-analysis showed that the PAI-1 4G/4G variant, 4G allele might be risk alleles for DN susceptibility in the Chinese population, and further studies in other ethic groups are required for definite conclusions.

Cited by 10 publications

References 9 publications

The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

The susceptibility of SERPINE1 rs1799889 SNP in diabetic vascular complications: a meta-analysis of fifty-one case-control studies

The role of rs1799889 genetic variation in Type 2 diabetes and Diabetic Nephropathy risk

Role of plasminogen activator inhibitor-1 gene polymorphisms in osteoporosis: A study in Chinese post-menopausal women

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