Association between partial-volume corrected SUVmax and Oncotype DX recurrence score in early-stage, ER-positive/HER2-negative invasive breast cancer

Lee, Sang Ho; Ha, Seunggyun; An, Hyun Joon; Lee, Jae Sung; Han, Wonshik; Im, Seock Ah; Ryu, Han Suk; Kim, Won Hwa; Chang, Jung Min; Cho, Nariya; Moon, Woo Kyung; Cheon, Gi Jeong

doi:10.1007/s00259-016-3418-1

Cited by 9 publications

(10 citation statements)

References 30 publications

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“…More recently, reports regarding the usefulness of volume-based quantitative parameters (SUVmax, MTV, TLG) for predicting prognosis using major receptor types have been presented. A study of ER+/HER2-cancer patients showed primary tumor MTV as an independent factor for predicting recurrence [19], while primary tumor SUVmax was demonstrated to be an independent factor in another report [20]. Also, primary tumor SUVmax was shown to be an independent factor with influence on recurrence in triple-negative cancer patients [21].…”

Section: Discussionmentioning

confidence: 95%

“…Although previous studies of stage operable breast cancer patients only evaluated primary tumor quantitative FDG-PET/CT values as imaging biomarkers [2,[4][5][6][18][19][20][21], cases with a lower primary tumor SUVmax value as compared to that for nodal SUVmax are commonly encountered in clinical situations. In the present cohort as well, it was observed in 10.2-30.9% and we defined that as maximum SUVmax, which is considered to be a strong point of this report.…”

Section: Discussionmentioning

confidence: 99%

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Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I-III breast cancer: Multicenter study

et al. 2021

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Objectives: This study investigated harmonized pretreatment volume-based quantitative FDG-PET/CT parameters in breast cancer patients for prognostic value. Results: During a median overall follow-up period of 5.3 years, 91 patients had recurrence and 40 died. Multivariate analysis of ER-positive/HER2-negative patients showed high maximum standardized uptake value (SUVmax) (p = 0.018), high total lesion glycolysis (TLG) (p = 0.010), and clinical N-classification (p = 0.0027) as independent negative predictors of RFS, while high maximum SUVmax (p = 0.037), advanced clinical T-classification (p = 0.030), and advanced TNM stage (p = 0.0067) were independent negative predictors of OS. For recurrence and death in HER2positive patients, high total TLG (p = 0.037, p = 0.0048, respectively) and advanced TNM stage (p = 0.048, p = 0.046, respectively) were independent prediction factors. In the triple-negative group, independent factors related to recurrence and death were high maximum SUVmax (p = 0.0014, p = 0.0003, respectively) and advanced TNM stage (p < 0.0001, p < 0.0001, respectively). Materials and Methods: Records of 546 stage I-III invasive breast cancer patients, including 344 estrogen receptor (ER)-positive/human epidermal growth factor receptor 2 (HER2)-negative, 110 HER2-positive, and 92 triple-negative cases, treated at four institutions were reviewed retrospectively. Harmonized primary tumor and nodal maximum SUVmax, metabolic tumor volume (MTV), and TLG indicated in pretreatment FDG-PET/CT results were analyzed. Evaluations of relationships of clinicopathological factors, volume-based quantitative parameters, recurrence-free survival (RFS), and overall survival (OS) for each subtype were performed with a Cox proportional hazards model and log-rank test.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I-III breast cancer: Multicenter study

et al. 2021

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“…Lee et al did not include BC with tumour size < 8 mm. Even with this precaution, when SUV values were not corrected for partial volume effect, results were not significant [7].…”

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confidence: 94%

“…Association between high baseline tumour SUV max measured by 18 FDG-PET/CT and some poor prognostic factors such as high tumor grade is well known [5,6]. In this issue of the European Journal of Nuclear Medicine and Molecular Imaging, Lee and colleagues report on a potential new role of 18 FDG-PET/CT in early stage BC patients: prediction of the results of the Oncotype DX RS [7]. In a retrospective analysis of 38 patients with small (only one patient had a tumor > 3 cm) and nodenegative breast cancer, partial-volume corrected tumour SUV max (PVC-SUV max ) had significant association with the Oncotype DX RS; a PVC-SUV max higher than a cutoff value of 4.96 predicted intermediate-to-high RS.…”

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confidence: 99%

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Is 18FDG uptake useful to decide on chemotherapy in ER+/HER2- breast cancer?

Groheux

Hindié

2016

Eur J Nucl Med Mol Imaging

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Total metabolic tumor volume and spleen metabolism on baseline [18F]-FDG PET/CT as independent prognostic biomarkers of recurrence in resected breast cancer

Seban

Rouzier

Latouche

et al. 2021

Eur J Nucl Med Mol Imaging

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de Total metabolic tumor volume and spleen metabolism on baseline [18F]-FDG PET/CT as independent prognostic biomarkers of recurrence in resected breast cancer

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Association between partial-volume corrected SUVmax and Oncotype DX recurrence score in early-stage, ER-positive/HER2-negative invasive breast cancer

Abstract: High PVC-SUVmax on (18)F-FDG PET/CT was significantly associated with an intermediate-to-high Oncotype DX RS. PVC metabolic parameters on (18)F-FDG PET/CT can be used to predict the Oncotype DX RS in patients with early-stage, ER-positive/HER2-negative breast cancer.

Cited by 9 publications

References 30 publications

Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I-III breast cancer: Multicenter study

Harmonized pretreatment quantitative volume-based FDG-PET/CT parameters for prognosis of stage I-III breast cancer: Multicenter study

Is 18FDG uptake useful to decide on chemotherapy in ER+/HER2- breast cancer?

Total metabolic tumor volume and spleen metabolism on baseline [18F]-FDG PET/CT as independent prognostic biomarkers of recurrence in resected breast cancer

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