Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults

Tsai, Ming Chieh; Lin, Chien‐Yu; Lin, Chia-Min; Chen, Mei-Huei; Hsu, Sandy Huey-Jen; Chien, Kuo‐Liong; Sung, Fung‐Chang; Chen, Pau‐Chung; Su, Ta‐Chen

doi:10.1016/j.ijheh.2015.03.008

Cited by 108 publications

(63 citation statements)

References 37 publications

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“…Results from the remaining four studies pointed in different directions as they did for the other investigated PFAS (PFOS, PFHxS, PFHpS, PFNA, PFDA, PFUnA; see Table 4). For SHBG, FSH, inhibin B and the ratio between the latter two, no consistent associations were reported with any PFASs (PFOA, PFOS, PFHxS, PFHpS, PFNA, PFDA, PFUnA; see Table 4), except for the adolescents included in the study by Tsai et al (2015) where higher PFOS and to some extent PFNA and PFUnA were associated with lower FSH.…”

Section: Reproductive Hormones and Related Outcomesmentioning

confidence: 81%

“…However, the nine other studies that investigated the association between testosterone and PFOA had inconsistent results (see Table 4). Three studies found tendencies towards lower testosterone with higher exposure to PFOS (Joensen et al 2009;Raymer et al 2012), while four studies found no support for such an association (Specht et al 2012;Lewis et al 2015;Tsai et al 2015;Den Hond et al 2015). For PFHxS, PFNA, PFDA, PFUnA and PFHpS, there was no consistency regarding an association with testosterone levels (Specht et al 2012;Joensen et al 2013;Lewis et al 2015;Tsai et al 2015).…”

Section: Reproductive Hormones and Related Outcomesmentioning

confidence: 98%

“…Thirteen studies were cross-sectional Sakr et al 2007;Costa et al 2009;Joensen et al 2009;Raymer et al 2012;Specht et al 2012;Toft et al 2012;Joensen et al 2013;Jørgensen et al 2014;Leter et al 2014;Governini et al 2015;Lewis et al 2015;Tsai et al 2015), two were from a pregnancy planner cohort (Buck Louis et al 2013;Buck Louis et al 2015) and one was a case-control study (Den Hond et al 2015). Three studies were occupational Sakr et al 2007;Costa et al 2009) while the remaining studies studied non-occupationally exposed populations.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Three studies were occupational Sakr et al 2007;Costa et al 2009) while the remaining studies studied non-occupationally exposed populations. Nine reported on semen characteristics (Joensen et al 2009;Raymer et al 2012;Specht et al 2012;Toft et al 2012;Joensen et al 2013;Leter et al 2014;Buck Louis et al 2015;Den Hond et al 2015;Governini et al 2015) and 10 studies reported on the associations between PFASs and reproductive hormone levels Sakr et al 2007;Costa et al 2009;Joensen et al 2009;Raymer et al 2012;Specht et al 2012;Joensen et al 2013;Den Hond et al 2015;Lewis et al 2015;Tsai et al 2015). Two studies reported on TTP (Buck Louis et al 2013;Jørgensen et al 2014).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Overall, the evidence from rodent studies to some extent supports an association between PFAS exposure and impaired fertility, however, the mechanisms behind potential reproductive effects of PFASs are not well established. In both males and females, endocrine disruption may be a possible mechanism as suggested in animal studies, but the current evidence from human in vivo studies is very limited (Barrett et al 2015;Lewis et al 2015;Tsai et al 2015). In adult rats, Ló pez-Doval et al (2014) demonstrated that PFOS had several potential effects on the hypothalamic-pituitary-testicular axis, including both gonadotropin releasing hormone, LH, FSH and testosterone.…”

mentioning

confidence: 99%

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Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review

Bach

Vested

Jørgensen

et al. 2016

Critical Reviews in Toxicology

124

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Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are found widespread in the environment and humans. The relation of PFASs to fertility has now been examined in a relatively large number of epidemiologic studies and a synthesis is in order. The aim of this study was to assess the current human epidemiologic evidence on the association between exposure to PFASs and measures of human fertility, with particular emphasis on perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA). Systematic literature searches were initially conducted in MEDLINE and EMBASE and subsequently in references and citations of included papers. Studies were included if they assessed exposure to PFASs in biological samples in relation to reproductive hormones, semen characteristics, or time to pregnancy (TTP). Study characteristics and results were abstracted to predefined forms, and the studies were assessed for the risk of bias and confounding. Sixteen studies investigated the association between PFAS exposure in men and semen parameters, reproductive hormone levels, or TTP. There was a lack of consistent results among the numerous investigated exposure-outcome combinations. However, subtle associations between higher PFOS and lower testosterone or abnormal semen morphology cannot be excluded. Eleven studies assessed the association between PFAS exposure in women and TTP or reproductive hormones levels. Four of eight studies found prolonged TTP with higher PFOS or PFOA, but only one study found an association when restricting to nulliparous women. In men, there is little evidence of an association between PFAS exposure and semen quality or levels of reproductive hormones. For PFOS and PFOA, the literature indicates an association with female fecundability in parous women, which is most likely not causal.

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Section: Reproductive Hormones and Related Outcomesmentioning

confidence: 81%

Section: Reproductive Hormones and Related Outcomesmentioning

confidence: 98%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review

Bach

Vested

Jørgensen

et al. 2016

Critical Reviews in Toxicology

124

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Long Chain Per/Polyfluoroalkyl Acids (C8 and Above)

Dourson,

Kougias,

Anderson

et al. 2024

Patty's Toxicology

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This chapter is about a series of per‐ and polyfluoroalkyl substances (PFAS) that can also be described as “long‐chain” perfluoroalkyl acids (PFAAs). The overall structure of PFAAs is a lengthy carbon chain with fluorine atoms substituting for hydrogen atoms and either a carboxylic or sulfonate head group. PFAAs are unusually chemically stable, water and oil resistant, and useful for many industrial applications, such as in the formation of polymers. In biological systems, these chemicals are generally well‐absorbed, resistant to metabolism, but also have the unusual property of widely different elimination kinetics among and within mammalian species. The range of estimated elimination half‐lives in humans for the perfluorooctanoic acid (PFOA), for example, is quite large ranging from one‐half to as much as 14 years, although a recent estimate from an international collaboration places this value closer to 1 year. The available literature on PFAAs is voluminous. This chapter will not attempt to review all this literature. Rather human studies will be emphasized, but since these studies nearly always suggest associations between PFAA exposure and health outcomes, this will be followed by studies in experimental animals that give insights into the human evidence. Afterward, a summary of attempts to estimate potential human risk by various international agencies will be described. What will become obvious, however, is that the overall uncertainty in the database of these chemicals has led to widely divergent risk assessment positions that need to be resolved. Risk management decisions on this class of chemistries are seen to be premature without such scientific resolution.

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Ableitung von HBM-I-Werten für Perfluoroktansäure (PFOA) und Perfluoroktansulfonsäure (PFOS) – Stellungnahme der Kommission „Humanbiomonitoring“ des Umweltbundesamts

Umweltbundesamt¹

2018

Bundesgesundheitsbl

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Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults

Cited by 108 publications

References 37 publications

Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review

Perfluoroalkyl and polyfluoroalkyl substances and measures of human fertility: a systematic review

Long Chain Per/Polyfluoroalkyl Acids (C8 and Above)

Ableitung von HBM-I-Werten für Perfluoroktansäure (PFOA) und Perfluoroktansulfonsäure (PFOS) – Stellungnahme der Kommission „Humanbiomonitoring“ des Umweltbundesamts

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