Association between personal exposure to ambient metals and respiratory disease in Italian adolescents: a cross-sectional study

Rosa, Maria José; Benedetti, Chiara; Peli, Marco; Donna, Filippo; Nazzaro, Marco Stefano; Fedrighi, Chiara; Zoni, Silvia; Marcon, Alessandro; Zimmerman, Neil J.; Wright, Rosalind J.; Lucchini, Roberto

doi:10.1186/s12890-016-0173-9

Cited by 25 publications

(6 citation statements)

References 46 publications

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“…The assessment of air-Mn in order to evaluate the influence of air pollution on human Mn exposure and the related health implications is of relevant and growing interest. Previous Italian studies, which assessed levels of PM 10 air-Mn using a 24-h personal sampling, reported deficits in olfactory and motor neuron function in the higher exposed group of both elderly (57) and adolescents (58), as well an increased risk of asthma only in the youngest population (35). More recently, in the absence of facility emissions data for individual study subjects, a US study used the long-term air measurements available from local air monitoring stations in order to derive receptor-specific concentrations of respirable air Mn through total suspended particulates (TSP), PM 10 and PM 2.5 (59).…”

Section: Discussionmentioning

confidence: 99%

Determinants of serum manganese levels in an Italian population

Filippini

Michalke

Grill

et al. 2017

Molecular Medicine Reports

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Manganese (Mn) is both essential and toxic for humans, mainly depending on the total levels and its species. Main sources of exposure include food and air pollution, particularly motorized traffic. We sought to determine the potential influence of these sources on serum total levels of Mn and Mn species. We selected a random sample of municipality residents from an Italian urban municipality, from whom we collected detailed personal information, dietary habits and a blood sample for serum Mn determination. We also assessed outdoor air Mn exposure, by modeling levels of particulate matter ≤10 µm (PM10) from motorized traffic at the residence of geocoded subjects. Serum Mn species generally showed higher levels in males and positive correlation with age, while no such differences were found according to smoking habits or use of dietary supplements. Among nutrients, only iron intake showed a relation with Mn [an inverse correlation with Mn‑ferritin (Mn‑Fer) and a direct one with inorganic‑Mn (Inorg‑Mn)]. Meat consumption directly correlated and fish and seafood inversely correlated with total Mn, Mn‑transferrin (Mn‑Tf) and Mn-citrate (Mn-Cit). Fruits and vegetables, including legumes and nuts, generally showed a positive correlation with all Mn species, especially Mn‑Cit, and an inverse one with Inorg‑Mn. Odds ratios (ORs) of having serum Mn levels above median value increased with increasing PM10 tertiles, with an OR for highest‑to‑lowest tertile of 7.40 (1.36‑40.25) in multivariate analysis. Analyses for Mn species did not highlight a clear comparable pattern. In conclusion, our results seem to demonstrate that PM10 exposure positively influences total Mn serum levels, while single Mn species show conflicting results.

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Section: Discussionmentioning

confidence: 99%

Determinants of serum manganese levels in an Italian population

Filippini

Michalke

Grill

et al. 2017

Molecular Medicine Reports

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“…Pulmonary function indices and asthma in children were linked with Pb [ 27 , 28 ], Mn, Ni, and Cr [ 29 , 30 ], as well as Co and Zn [ 31 ]. Likewise, maternal Pb has been reported in association with elevated blood pressure in 5-year-old children [ 32 ] and prenatal exposure to Cd—with an increased risk of obesity at the age of five [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

Karakis

Landau

Gat

et al. 2021

Environ Health Prev Med

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Background The majority of studies linking exposure to metals with certain health outcomes focus on known toxic metals. Alternatively, this study assesses the extent to which exposure to a wider range of metals during gestation is associated with childhood morbidity. Methods We analyzed the concentrations of 25 metals found in urine samples of 111 pregnant women of Arab-Bedouin origin collected prior to birth. In addition, we collected medical records on their offspring for six years following birth, including every interaction with HMOs, local hospitals, and pharmacies. Results The main types of morbidities diagnosed and treated during this period were preterm births, malformations, asthma-like morbidity, cardiovascular and behavioral problems, and obesity. Multivariable analysis showed that offspring born before term were more likely to have been exposed to elevated maternal concentrations of zinc, thallium, aluminum, manganese, and uranium, all with adjusted relative risk above 1.40 for an increase by each quintile. Likewise, children with asthma had been exposed to higher levels of magnesium, strontium, and barium at gestation, while behavioral outcomes were associated with elevated biometals, i.e., sodium, magnesium, calcium, selenium, and zinc, as well as higher levels of lithium, cobalt, nickel, strontium, cadmium, vanadium, arsenic, and molybdenum. A heatmap of adjusted relative risk estimates indicates the considerable implications that exposure to metals may have for preterm birth and developmental outcomes. Conclusions The current study shows that perinatal exposure to metals is adversely associated with pediatric morbidity. Further such analyses on additional samples are warranted.

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“…Previous studies observed that asthma induced by heavy metals was triggered by the immune system, indicating that heavy metals have great inflammatory potential and immunomodulatory effects on individuals [ 27 , 28 ]. Many studies have reported the association between heavy metals (Pb, Cd, Hg and Mn) and asthma [ 24 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011–2018

Wen

Giri

et al. 2023

JCM

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(1) Background: Heavy metals are widely used and dispersed in the environment and people’s daily routines. Many studies have reported an association between heavy metal exposure and asthma. Blood eosinophils play a crucial role in the occurrence, progression, and treatment of asthma. However, there have thus far been few studies that aimed to explore the effects of heavy metal exposure on blood eosinophil counts in adults with asthma. Our study aims to discuss the association between metal exposure and blood eosinophil counts among asthmatic adults. (2) Methods: A total of 2026 asthmatic individuals were involved in our research from NHANES with metal exposure, blood eosinophils, and other covariates among the American population. A regression model, the XGBoost algorithm, and a generalized linear model (GAM) were used to explore the potential correlation. Furthermore, we conducted a stratified analysis to determine high-risk populations. (3) Results: The multivariate regression analysis indicated that concentrations of blood Pb (log per 1 mg/L; coefficient β, 25.39; p = 0.010) were positively associated with blood eosinophil counts. However, the associations between blood cadmium, mercury, selenium, manganese, and blood eosinophil counts were not statistically significant. We used stratified analysis to determine the high-risk group regarding Pb exposure. Pb was identified as the most vital variable influencing blood eosinophils through the XGBoost algorithm. We also used GAM to observe the linear relationship between the blood Pb concentrations and blood eosinophil counts. (4) Conclusions: The study demonstrated that blood Pb was positively correlated with blood eosinophil counts among asthmatic adults. We suggested that long-time Pb exposure as a risk factor might be correlated with the immune system disorder of asthmatic adults and affect the development, exacerbation, and treatment of asthma.

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Association between personal exposure to ambient metals and respiratory disease in Italian adolescents: a cross-sectional study

Cited by 25 publications

References 46 publications

Determinants of serum manganese levels in an Italian population

Determinants of serum manganese levels in an Italian population

Maternal metal concentration during gestation and pediatric morbidity in children: an exploratory analysis

Association between Exposure to Selected Heavy Metals and Blood Eosinophil Counts in Asthmatic Adults: Results from NHANES 2011–2018

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