Association between pituitary height and growth response to recombinant human growth hormone in prepubertal children with growth hormone deficiency

Zhang, Zhixin; Zhang, Xiaomeng; Niu, Wenquan; Yuan, Yuan

doi:10.1007/s12020-022-03217-2

Endocrine

2022

DOI: 10.1007/s12020-022-03217-2

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Association between pituitary height and growth response to recombinant human growth hormone in prepubertal children with growth hormone deficiency

Zhixin Zhang

Xiaomeng Zhang

Wenquan Niu

et al.

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2024

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Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature

Kiremitci Yilmaz,

Yilmaz Ovali,

Ozalp Kizilay

et al. 2024

Endocrine

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Purpose Height age (HA) and bone age (BA) delay is well known in the patients with short stature. Therefore assessing pituitary hypoplasia based on chronological age (CA) might cause overdiagnosis of pituitary hypoplasia. We aimed to investigate the diagnostic and prognostic value of the PH and PV based on CA, HA, or BA in the patients with GHD. Methods Fifty-seven patients with severe and 40 patients with partial GHD and 39 patients with ISS assigned to the study. For defining the most accurate diagnosis of pituitary hypoplasia, PH and PV were evaluated based on CA, BA and HA. The relationship of each method with clinical features was examined. Results The mean PV was significantly larger in patients with ISS compared to the GH-deficient patients. PV was more correlated with clinical features including height SDS, stimulated GH concentration, IGF-1 and IGFBP-3 SDS, height velocity before and after rGH therapy. We found BA-based PV could discriminate GHD from ISS (Sensitivity: 17%, specificity: 98%, positive predictive value: 94%, negative predictive value: 39%), compared to the other methods based on PH or PV respect to CA and HA. 3% of patients with ISS, 17% of patients with GHD had pituitary hypoplasia based on PV-BA. Conclusion PV based on BA, has the most accurate diagnostic value for defining pituitary hypoplasia. But it should be kept in mind that there might be still misdiagnosed patients by this method. PV is also a significant predictor for the rGH response.

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Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature

Kiremitci Yilmaz,

Yilmaz Ovali,

Ozalp Kizilay

et al. 2024

Endocrine

View full text Add to dashboard Cite

show abstract

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Association between pituitary height and growth response to recombinant human growth hormone in prepubertal children with growth hormone deficiency

Cited by 1 publication

References 19 publications

Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature

Pitfalls of diagnosing pituitary hypoplasia in the patients with short stature

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