Association Between Polymorphic Genes of Folate Metabolism and Early Pregnancy Losses

Tretyakova, T. B.; Demchenko, N. S.

doi:10.17749/2313-7347.2018.12.1.042-052

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Likewise, the genotype and allele frequencies of DNMT3L rs2276248 in our study were consistent with those determined among healthy French women [32]. However, they were completely in contrast with the genotype and allele frequencies for DNMT3B rs2424913, DNMT3B rs1569686, DNMT3L rs2276248, and DNMT3L rs2070565 recorded among healthy Chinese population, which have been published in several case-control studies, and we expect that the cause of difference might be attributed to the ethnic factor [19,33,34]. The heterozygous genotype (CT) frequency for SYCP3 T657C was also comparable to that reported in an Iranian study [15].…”

Section: Discussionsupporting

confidence: 89%

Prevalence of Some Gene Polymorphisms Related to Early Pregnancy Loss among Russian Women

Ahmed

Muradian

Азова

2019

Vestn. Ross. univ. družby nar., Ser. Med.

View full text Add to dashboard Cite

Background. A variety of biological processes regulated by differential gene expression are required to maintain a normal gestation and accordingly, the mutations and polymorphisms in such genes may cause miscellaneous biological disorders that eventually result in early pregnancy loss. Many studies reported that aberrant fetal DNA methylation as well as embryonic chromosome abnormalities may lead to impairment of fetal early growth and development. Therefore, we have aimed to genotype several gene polymorphisms might be involved in the above-mentioned biological disorders to screen their prevalence in Russian population. Materials and methods. 81 Russian women without previous history of normal pregnancy or early abortion were recruited into this population study to determine the genotype and allele frequencies through genotyping using RFLP-PCR method for DNMT3B rs2424913, DNMT3B rs1569686, DNMT3A rs7590760, DNMT1 rs2228611, DNMT1 rs8101626, DNMT3L rs2276248, and DNMT3L rs2070565, allele-specific PCR for SYCP3 T657C, and real-time PCR for MTHFR rs1801133, MTHFR rs1801131, MTR rs1805087, and MTRR rs1801394. Results. Minor homozygous genotypes and minor alleles of the polymorphisms DNMT3B rs2424913 (TT: 11.1%, T: 37.05%), DNMT1 rs2228611 (GG: 18.5%, G: 40.75%), and DNMT1 rs8101626 (GG: 16.0%, G: 40.1%) were quite prevalent in Russian women and as frequent as those of the well-studied polymorphisms: MTRR rs1801394 (GG: 27.2%, G: 50.65%), MTHFR rs1801131 (CC: 17.3%, C: 40.15%), and MTHFR rs1801133 (TT: 11.1%, T: 29.0%).The heterozygous genotype of SYCP3 T657C (CT: 12.3%, T: 6.15%) was also quite frequent. Conclusion. Based on our study and literature data, we suggest that DNMT3B rs2424913, DNMT1 rs2228611, DNMT1 rs8101626, and SYCP3 T657C polymorphisms along with the common folate cycle gene polymorphisms can be potential genetic predictors for early pregnancy loss in Russian women.

show abstract