Association Between Polymorphism of Tumor Necrosis Factor-α Promoter and Response to Lamivudine Treatment in Patients with Chronic Hepatitis B

Park, Yong Kwang; Lee, Jung Min; Kim, Do Young; Chang, Heon-Young; Kim, Ja Kyung; Lee, Chun Kyon; Park, Jun Yong; Ahn, Sang Hoon; Lee, Kwan Sik; Han, Kwang Hyub

doi:10.1007/s10620-009-0983-1

Cited by 6 publications

(4 citation statements)

References 25 publications

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“…Unlike our results, the TNF-α (-308) G allele was found to be higher in the chronic hepatitis group in two studies conducted in Turkey 17,18 . In a meta-analysis by Zhang et al in which studies conducted on the Chinese population were compiled, the TNF-α (-308) A allele was associated with a decrease in the chronicity of HBV, similar to our study 19 . In addition to these results, in a Brazilian study, the TNF-α (-308) A allele and AA genotype were associated with In chronic hepatitis B patients, despite the increase in serum IL-17 levels, lower IL-17R expression levels and a weaker response to IL-17 were detected in vitro compared to the healthy control group 4,5 .…”

Section: Discussionsupporting

confidence: 90%

Relationship between IL-17, TNF-α, IL-10, IFN-γ, and IL-18 polymorphisms with the outcome of hepatitis B virus infection in the Turkish population

Temel

Akçam

Caner

et al. 2023

Rev. Assoc. Med. Bras.

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OBJECTIVE: Hepatitis B virus is a global threat that can lead to liver cirrhosis and hepatocellular carcinoma. For the treatment of chronic hepatitis B virus, polymorphisms might be an option for gene treatments. This study aimed to investigate the effects of IL-17, TNF-α, IL-10, IFN-γ, and IL-18 gene polymorphisms on hepatitis B virus infection in the Turkish population. METHODS: The genotypes and allele distribution of 75 patients exposed to hepatitis B virus and 50 healthy control individuals were analyzed. The real-time polymerase chain reaction method was used for identification. RESULTS: A correlation was observed between susceptibility to hepatitis B virus infection and IL-17 Exon 3/3'UTR (rs1974226) C, IL-17 Exon 3 (rs763780) A, IL-18 (-607) (rs1946518) A alleles, and IL-17 Exon 3 (rs763780) AA genotype (p=0.006, p=0.009, p=0.025, and p=0.008, respectively). Furthermore, IL-18 (-137) (rs187238) TT genotype and TNF-α-308 (rs1800629) G and A alleles, were associated with protection against hepatitis B virus infection (p=0. 0351 and p=0.032, respectively). CONCLUSION: This study demonstrated that TNF-α (-308), IL-17 (Exon 3/3' UTR), IL-17 (Exon 3), and IL-18 (-607) polymorphisms are associated with hepatitis B virus infection. Therefore, these may serve as potential therapeutic targets for chronic viral hepatitis in the Turkish population.

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Section: Discussionsupporting

confidence: 90%

Relationship between IL-17, TNF-α, IL-10, IFN-γ, and IL-18 polymorphisms with the outcome of hepatitis B virus infection in the Turkish population

Temel

Akçam

Caner

et al. 2023

Rev. Assoc. Med. Bras.

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“…There is very little data examining the influence of genetic variations in TLRs or TLR mediated pathways on outcomes from therapy for HBV. As mentioned, the A-allelic polymorphism of the TNF-α promoter at position 238 has been associated with non-response to lamivudine treatment for chronic HBV in a single study involving Asian patients [77]. This study found no effect from the 308AG variant.…”

Section: Tlr Pathway Polymorphisms and Response To Therapy For Hbvmentioning

confidence: 45%

“…For example, the 238GG genotype has been associated with persistent infection and self-limited disease in different reports [74][75][76]. Polymorphisms at position 238 may also influence response to antiviral therapy with lamivudine [77]. The 308GG genotype has been associated with a risk of decompensated cirrhosis in an Italian study and Asian patients homozygous for the 308G/238G haplotype appeared at higher risk of persistent infection [66,78].…”

Section: Cytokines and Hbvmentioning

confidence: 99%

Polymorphisms of Toll-Like Receptors and Their Pathways in Viral Hepatitis

Sawhney

Visvanathan

2011

Antiviral Therapy

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Toll-like receptors (TLRs) are an important part of the innate immune response to a variety of pathogens including hepatic viral infections. Activation of TLRs stimulates a complex intracellular signalling cascade that results in production of proinflammatory cytokines and interferons important for antiviral responses as well as induction of the adaptive arm of the immune system. There is substantial evidence for an important role for TLRs and TLR-mediated signalling in the pathogenesis and outcomes of hepatitis B and C in particular, but it might also influence responses to other viral hepatitis infections. Several single nucleotide polymorphisms (SNPs) of TLRs, relevant adaptor molecules and cytokines mediated by TLR signalling have been described that alter innate immune responses and have been implicated in a variety of human diseases including viral and other infections. There is now significant evidence that a number of TLR SNPs can affect various clinical outcomes in Caucasian patients with chronic HCV. However, the role of these polymorphisms in acute and other chronic hepatitis infections, including HBV as well as in non-Caucasian populations, has not been elucidated. In addition, results for SNPs downstream of TLR activation, such as in relevant cytokines, are inconsistent and their influence requires further investigation to determine the clinical significance of genetic variations in these mediators.

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“…Responding or not to lamivudine treatment depends on host factors such as the patient's immune system or cytokine network, as well as viral factors such as the particular mutation or genotype. Regarding host genetic factors, it was reported that the HLA-DRB1*010101 allele and TNF-a promoter at position À238 was associated with the response to lamivudine treatment [20,21]. The 2',5-oligoadenylate synthetase, eIF-2a, and MxA gene promoter at nt À88, including IL-28B, may play an important role in the response to IFN with CHB [16,[22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Association between gene polymorphisms of IL-28 and response to lamivudine in Chinese rural patients with chronic hepatitis B

Wang

Shang

et al. 2013

Scandinavian Journal of Gastroenterology

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Association Between Polymorphism of Tumor Necrosis Factor-α Promoter and Response to Lamivudine Treatment in Patients with Chronic Hepatitis B

Abstract: Our study demonstrated that the non-response to lamivudine treatment in patients with chronic hepatitis B might be related to the A allelic polymorphism of TNF-alpha promoter at position -238.

Cited by 6 publications

References 25 publications

Relationship between IL-17, TNF-α, IL-10, IFN-γ, and IL-18 polymorphisms with the outcome of hepatitis B virus infection in the Turkish population

Relationship between IL-17, TNF-α, IL-10, IFN-γ, and IL-18 polymorphisms with the outcome of hepatitis B virus infection in the Turkish population

Polymorphisms of Toll-Like Receptors and Their Pathways in Viral Hepatitis

Association between gene polymorphisms of IL-28 and response to lamivudine in Chinese rural patients with chronic hepatitis B

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