Association between polymorphisms of the <i>GSDMB</i> gene and allergic rhinitis risk in the Chinese population: a case-control study

Shamsi, Bilal Haider; Chen, Haiyuan; Xiong, Yan; Liu, Mingxia; Liu, Yonglin

doi:10.1080/02770903.2023.2185893

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Imraish et al ( 2022) reported that GSDMB-rs7216389 has potential influence on IgE levels of patients with asthma in Jordanian population. Shamsi et al (2023) reported that GSDMB-rs4795400, rs2305479, and rs12450091 were associated with risk of allergic rhinitis. As for cancer studies about GSDMB polymorphisms, Lutkowska et al (2017) found that rs8067378 A>G variant may elevate the expression of GSDMB and increased the risk of the cervical squamous cell carcinomas in a Polish population, while Li et al (2022) further reported that rs8067378 was a risk-reducing variant for cervical squamous intraepithelial lesion.…”

Section: Discussionmentioning

confidence: 99%

Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population

Zhang

Liu

2023

Front. Genet.

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Background: Pyroptosis is essential for the remodeling of tumor immune microenvironment and suppression of tumor development. However, there is little information available about pyroptosis-related gene polymorphisms in non-small cell lung cancer (NSCLC).Methods: Six SNPs in the GSDMB, GSDMC, and AIM2 were genotyped in 650 NSCLC cases and 650 healthy controls using a MassARRAY platform.Results: Minor alleles of rs8067378, rs2305480, and rs77681114 were associated with a lower risk of NSCLC (p < 0.005), whereas rs2290400 and rs1103577 were related to an increased risk (p < 0.00001). Moreover, rs8067378-AG/GG, rs2305480-GA/AA, and rs77681114-GA/AA genotypes were associated with a decrease in NSCLC risk (p < 0.005). In contrast, the TC/CC genotypes of rs2290400 and rs1103577 were associated with an elevated NSCLC risk (p < 0.0001). Based on the analysis of genetic models, minor alleles of rs8067378, rs2305480 and rs77681114 were related to reduced risk of NSCLC (p < 0.05); whereas rs2290400 and rs1103577 were related to increased risk (p < 0.01).Conclusion: Our findings provided new insights into the roles of pyroptosis-related genes in NSCLC, as well as new factors to be considered for assessing the risk of developing this cancer.

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Section: Discussionmentioning

confidence: 99%

Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population

Zhang

Liu

2023

Front. Genet.

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LINC00299 polymorphisms rs891058, rs13395467, and rs13398375 reduce the risk of allergic rhinitis among the Chinese Han population

Liu,

Zhang,

Wang

et al. 2023

Gene

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Pyroptosis, gasdermins and allergic diseases

Panganiban,

Nadeau,

2024

Allergy

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Pyroptosis is an inflammatory form of programmed cell death that is distinct from necrosis and apoptosis. Pyroptosis is primarily mediated by the gasdermin family of proteins (GSDMA‐E and PVJK), which, when activated by proteolytic cleavage, form pores in the plasma membrane, leading to cell death. While much of the past research on pyroptosis has focused on its role in cancer, metabolic disorders, and infectious diseases, recent experimental and observational studies have begun to implicate pyroptosis in allergic diseases. These studies suggest that gasdermin‐mediated pyroptosis contributes to the development of allergic conditions and could offer novel targets for therapy. Here, we review our current understanding of pyroptosis with an emphasis on the role of gasdermins as executioners of pyroptosis and potential mediators to allergic disease. We highlight new discoveries that establish a mechanistic link between the biochemical actions of gasdermins and the onset of allergic diseases. Additionally, we discuss how pyroptosis and gasdermins might contribute to the dysfunction of epithelial barrier, a key factor believed to initiate the progression of various allergic diseases.

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Association between polymorphisms of the GSDMB gene and allergic rhinitis risk in the Chinese population: a case-control study

Cited by 3 publications

References 36 publications

Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population

Pyroptosis-related genes GSDMB, GSDMC, and AIM2 polymorphisms are associated with risk of non-small cell lung cancer in a Chinese Han population

LINC00299 polymorphisms rs891058, rs13395467, and rs13398375 reduce the risk of allergic rhinitis among the Chinese Han population

Pyroptosis, gasdermins and allergic diseases

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