Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

Zhang, Shangchao; Zhou, Na; Li, Rui; Rao, Wenwang; Yang, Mingxia; Cao, Bonan; Kang, Guolian; Kang, Qi; Zhu, Xiaojing; Li, Rixin; Yu, Yaqin; Yu, Qiong

doi:10.1159/000489654

Cited by 16 publications

(13 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we explored the relationship between variants of the C3 gene and the susceptibility to CAD and lipid levels by tagSNPs in a Chinese population. In recent years, two studies were conducted to explore the association between polymorphisms of the Complement 3 gene and diseases in Chinese Han populations [29, 30]. We found the frequencies of alleles in controls in the present study were similar to those in their studies.…”

Section: Discussionsupporting

confidence: 85%

Complement C3 gene polymorphisms are associated with lipid levels, but not the risk of coronary artery disease: a case-control study

Cai

Chen

et al. 2019

Lipids Health Dis

View full text Add to dashboard Cite

BackgroundCoronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Previous studies have shown that complement component 3 (C3) is associated with atherosclerosis and cardiovascular risk factors.MethodsWe conducted this study to evaluate the associations between tagSNPs in the C3 gene locus and the CAD susceptibility and lipid levels in the Chinese population. A hospital-based case-control study, including 1017 subjects (580 CAD patients and 437 non-CAD controls), was conducted. TagSNPs in the C3 gene were searched and genotyped by using the polymerase chain reaction-ligase detection reaction method.ResultsThe C3 levels were positively associated with the low-density lipoprotein cholesterol (LDL-C) levels (r = 0.269, P = 0.001). Compared with those in controls, the serum C3 levels in CAD patients were significantly higher (Control: 0.94 + 0.14 g/l; CAD: 1.10 + 0.19 g/l, P < 0.001). No significant differences in genotype or allele frequencies were observed between CAD patients and controls. The minor T allele of rs2287848 was associated with low apolipoprotein A1 (ApoA1) levels in controls (Bonferroni corrected P, Pc = 0.032). Linkage disequilibrium and haplotype analysis established two haplotype blocks (Block1: rs344555-rs2277984, Block 2: rs2287848-rs11672613) and six haplotypes. No significant associations between haplotypes and the risk of CAD were observed (all Pc > 0.05).ConclusionsThe results revealed that C3 gene polymorphisms were associated with the lipid levels, but not CAD susceptibility in the Chinese population.

show abstract

Section: Discussionsupporting

confidence: 85%

Complement C3 gene polymorphisms are associated with lipid levels, but not the risk of coronary artery disease: a case-control study

Cai

Chen

et al. 2019

Lipids Health Dis

View full text Add to dashboard Cite

show abstract

“…Some studies found an association with some SNPs of DRD2 gene with SCZ [ 9 , 25 , 26 , 27 , 52 , 53 , 54 ], whereas Zhang et al. found no association of DRD2 polymorphism with SCZ [ 55 ]. An association of rs1079727, rs2283265, rs1124492 SNPs with SCZ was found in the Han Chinese population living in Taiwan [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Association of DRD2 gene polymorphisms with schizophrenia in the young Bangladeshi population: A pilot study

Hussain

Siddiqui

Mondal

et al. 2020

Heliyon

View full text Add to dashboard Cite

Purpose DRD2 gene is considered one of the most important candidate genes for the schizophrenia (SCZ) development due to its role in dopamine signaling and no genetic association study has been conducted yet on the Bangladeshi SCZ patients. The objective of the present study was to investigate the association of DRD2 genetic polymorphisms (rs4648317, rs4936270, and rs7131056) with SCZ in the Bangladeshi population. Patients and methods This case-control study consisted of 101 SCZ patients and 101 controls. Genotyping was performed by the polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) method. Results The average ages were 22.15 and 22.09 years in patients and controls, respectively (p > 0.05). CT genotype of rs4936270 showed a significantly higher risk for the development of SCZ compared to CC genotype (OR = 2.0, p = 0.023), whereas no association was found for TT genotype. For the dominant model and T allele, rs4936270 showed a higher risk for the development of SCZ (OR = 2.01, p = 0.020; OR = 1.76, p = 0.021, respectively), while the recessive model had no association with SCZ. A statistically significant (OR = 2.70, p = 0.036) higher risk was found for the AA genotype, but no association was found for GA genotype of rs4648317 SNP compared to GG genotype. In case of dominant and recessive models, rs4648317 showed no association with SCZ. ‘A’ allele of rs4648317 SNP was found to be significantly associated with the elevated risk of SCZ (OR = 1.50, p = 0.044). No association with SCZ of rs7131056 SNP was found for AC, CC genotypes, dominant, recessive, and allele models. Furthermore, from the haplotyping analysis, we found that CAA and TAA haplotypes of rs4936270, rs7131056 and rs4648317 SNPs are associated with SCZ (χ2 = 8.26, p = 0.004; χ2 = 5.31, p = 0.021, respectively). After Bonferroni correction, the association of SCZ did not withstand with any genotype, allele and haplotype (p < 0.017) except CAA haplotype. Conclusion Our results suggest that DRD2 gene polymorphisms may be associated with the susceptibility of SCZ in the young Bangladeshi population.

show abstract

“…Higher C4 levels were likewise detected in the CSF of patients with schizophrenia [ 82 ]. The SNVs of the C3 gene with protective or harmful effects regarding schizophrenia onset were identified by a study that recruited more than 2000 Han Chinese individuals [ 83 ]. C3 mRNA expression was upregulated in the PFC of those that demonstrated depression followed by suicide [ 84 ].…”

Section: Microglia–synapse Interaction In Schizophreniamentioning

confidence: 99%

New Insights Regarding Diagnosis and Medication for Schizophrenia Based on Neuronal Synapse–Microglia Interaction

Izuo

Nitta

2021

JPM

View full text Add to dashboard Cite

Schizophrenia is a common psychiatric disorder that usually develops during adolescence and young adulthood. Since genetic and environmental factors are involved in the disease, the molecular status of the pathology of schizophrenia differs across patients. Recent genetic studies have focused on the association between schizophrenia and the immune system, especially microglia–synapse interactions. Microglia physiologically eliminate unnecessary synapses during the developmental period. The overactivation of synaptic pruning by microglia is involved in the pathology of brain disease. This paper focuses on the synaptic pruning function and its molecular machinery and introduces the hypothesis that excessive synaptic pruning plays a role in the development of schizophrenia. Finally, we suggest a strategy for diagnosis and medication based on modulation of the interaction between microglia and synapses. This review provides updated information on the involvement of the immune system in schizophrenia and proposes novel insights regarding diagnostic and therapeutic strategies for this disease.

show abstract

Association Between Polymorphisms of the Complement 3 Gene and Schizophrenia in a Han Chinese Population

Cited by 16 publications

References 32 publications

Complement C3 gene polymorphisms are associated with lipid levels, but not the risk of coronary artery disease: a case-control study

Complement C3 gene polymorphisms are associated with lipid levels, but not the risk of coronary artery disease: a case-control study

Association of DRD2 gene polymorphisms with schizophrenia in the young Bangladeshi population: A pilot study

New Insights Regarding Diagnosis and Medication for Schizophrenia Based on Neuronal Synapse–Microglia Interaction

Contact Info

Product

Resources

About