Association between PR interval prolongation and electro-anatomical substrate in patients with atrial fibrillation

Schumacher, Katja; Büttner, Petra; Dagres, Nikolaos; Sommer, Philipp; Dinov, Borislav; Hindricks, Gerhard; Bollmann, Andreas; Kornej, Jelena

doi:10.1371/journal.pone.0206933

Cited by 14 publications

(10 citation statements)

References 26 publications

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“…A significant correlation between PR interval prolongation and AF recurrence after radiofrequency ablation was also shown [15]. Furthermore, Schumacher et al recently demostrated that PR interval prolongation is associated with electro-anatomical substrate in AF patients, assuming that PR interval could be used as a marker for atrial remodelling before catheter ablation [16].…”

Section: Discussionmentioning

confidence: 99%

Association between echocardiographic parameters and biomarkers in probands with atrial fibrillation and different PR interval lengths: Insight from the epidemiologic LIFE Adult Study

Kornej

Zeynalova

Thiery³

et al. 2019

PLoS ONE

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Background PR interval prolongation is associated with increased risk for atrial fibrillation (AF). Different biomarkers are used to predict AF incidence and its outcomes. The aim of this study was to investigate the association between echocardiographic parameters and blood biomarkers in PR interval groups and AF. Methods The LIFE-Adult-Study is a population-based cohort study of randomly selected participants from Leipzig, Germany. In this cross-sectional analysis, individuals ≥40 years with available echocardiographic (LA diameter, EF) and laboratory data (creatinine, Troponin, NT-proBNP) were included. Results The study population comprised 1.429 individuals (median age 56 (IQR 48–66) years, 40% males) with complete ECG, echocardiographic and laboratory data. There were 48 (3.4%) individuals with AF, 177 (12.4%) with short, 138 (9.7%) with prolonged and 1.066 (74.5%) with normal PR interval. Individuals with PR interval prolongation had larger LA diameter, higher Troponin and NT-proBNP levels than individuals with normal PR interval, but lower than AF group (p<0.001). In contrast, eGFR was significantly higher in the group with PR interval prolongation than in AF, but lower than in individuals with normal PR interval (p<0.001). In the multivariate analysis, PR interval prolongation and AF shared similar characteristics, the only parameter different between both groups was NT-proBNP. Conclusions Individuals with PR interval prolongation and AF showed similarities in echocardiographic parameters, renal function and blood biomarker levels. Longitudinal studies are necessary to prove whether the PR interval prolongation may be considered as preliminary stage for AF.

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Section: Discussionmentioning

confidence: 99%

Association between echocardiographic parameters and biomarkers in probands with atrial fibrillation and different PR interval lengths: Insight from the epidemiologic LIFE Adult Study

Kornej

Zeynalova

Thiery³

et al. 2019

PLoS ONE

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“… 16 From these parameters, the PR interval can be defined as the time needed to conduct electrical impulses from the sinoatrial node to the atrioventricular node, and its prolongation has been related to the remodeling of atria and thus with an increased incidence of AF. 17 One of the new predictors of new-onset AF was demonstrated by a meta-analysis study. They observed that individuals who have frequent premature atrial contractions recorded by Holter monitoring or 12-lead electrocardiogram were at a 3-fold greater risk of new-onset AF than individuals without premature atrial contractions.…”

Section: Increasing Height Alters Atrial Dimensions and Conduction Pamentioning

confidence: 99%

The height as an independent risk factor of atrial fibrillation: A review

Sohail

Hassan

Yaqoob

et al. 2021

Indian Heart Journal

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Atrial fibrillation (AF) is characterized by abnormal heart rhythm. Among other well-known associations, recent studies suggest an association of AF with height. Height is related to 50 diseases spanning different body systems, AF is one of them. Since AF, a heterogeneous disease process, is influenced by structural, neural, electrical, and hemodynamic factors, height alters this process through its contribution to increasing atrial and ventricular size, leading to altered conduction patterns, autonomic dysregulation, and development of AF. Multiple underlying mechanisms associate height with AF. Apart from these indirect mechanisms, genome-wide association studies suggest the involvement of the same genes in AF and growth pathways. Tall stature is independently associated with a higher risk of AF development in healthy individuals. Since adult height is achieved much earlier than the onset of AF, protective measures can be taken in individuals with increased height to monitor, manage, and prevent the progression of AF.

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“…We observed PQ interval shortening after 5 weeks of HFFD in all groups (except HFFD 5+3 group), but there were no further changes either after another 3 weeks of the diet or after venlafaxine administration. Even though PQ interval prolongation is considered a risk factor for the development of atrial fibrillation (Schumacher et al, 2018), short PQ interval may be observed due to conduction abnormalities in the atrioventricular node and/or His-Purkyne network and may predispose the individuals to dysrhythmias (Moro & Cosio, 1980). PQ interval was found to be shortened in obese patients with no cardiovascular disease (Bilora et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

The effect of venlafaxine on blood pressure and ECG in rats fed with high-fat-fructose diet

Sasváriová

Michalikova

Kaprinay

et al. 2019

Interdisciplinary Toxicology

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Metabolic syndrome represents one of the major health, social and economic issues nowadays, and affects more than 25% people worldwide. Being a multifactorial health problem, metabolic syndrome clusters various features, such as obesity, dyslipidemia, hyperglycemia and hypertension. Each of these disturbances represents a risk factor for developing cardiovascular disease. Moreover, patients with metabolic syndrome are more likely to suffer from depression, thus treatment with antidepressants (e.g. venlafaxine) is often neccessary. However, many of the antidepressants themselves may contribute to worsening or even development of the metabolic syndrome, thus creating a “vicious circle”. The aim of this work was to investigate on the animal model of metabolic syndrome, i.e. on hypertriacylglycerolemic rats fed high-fat-fructose diet (HFFD): 1) the effect of a change in diet from HFFD to a standard diet (SD) and the effect of venlafaxine treatment, 2) during HFFD, 3) as well as during a changed diet to SD. We focused on biometric parameters, blood pressure and selected ECG parameters. We observed the reversibility of the present metabolic and cardiovascular changes by switching the HFFD to SD in the last 3 weeks of the experiment. Switch to the standard diet led to decrease of body weight, even in the presence of venlafaxine. Administration of venlafaxine caused the decrease of heart weight/body weight index in rats fed with HFFD compared to the untreated group fed with HFFD for 8 weeks. Blood pressure, which was increased in the HFFD group showed a tendency to decrease to control values after switching to the standard diet. Administration of venlafaxine led to significant increase in all parameters of blood pressure when rats were fed with HFFD throughout the whole experiment. In untreated rats fed with HFFD for 8 weeks, we observed a shorter PQ interval and prolonged QRS complex as well as QTc interval compared to untreated rats with diet switched to SD. This effect was potentiated by venlafaxine administered not only during HFFD but even after switch to SD. Our results point to the fact that metabolic syndrome is clearly affecting the function of the cardiovascular system by modifying blood pressure and electrical activity of the heart. Moreover, administration of venlafaxine may lead to worsening of the observed changes, especially in the presence of high-fat-fructose diet.

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Association between PR interval prolongation and electro-anatomical substrate in patients with atrial fibrillation

Cited by 14 publications

References 26 publications

Association between echocardiographic parameters and biomarkers in probands with atrial fibrillation and different PR interval lengths: Insight from the epidemiologic LIFE Adult Study

Association between echocardiographic parameters and biomarkers in probands with atrial fibrillation and different PR interval lengths: Insight from the epidemiologic LIFE Adult Study

The height as an independent risk factor of atrial fibrillation: A review

The effect of venlafaxine on blood pressure and ECG in rats fed with high-fat-fructose diet

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