Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort

Coker, Eric S.; Chevrier, Jonathan; Rauch, Stephen; Bradman, Asa; Obida, Muvhulawa; Crause, Madelein; Bornman, Riana; Eskenazi, Brenda

doi:10.1016/j.envint.2018.01.016

Cited by 169 publications

(74 citation statements)

References 65 publications

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“…Organochlorine pesticides (OCPs) are a class of persistent organic pollutants (POPs) that accumulate in the environment and can be distributed through runoffs into surface water or groundwater [ 1 ]. OCPs with low estrogenic or anti-estrogenic effects are classified as endocrine disruptors.…”

Section: Introductionmentioning

confidence: 99%

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Chen

Santos

Que

et al. 2018

IJERPH

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Only few studies have focused on organochlorine pesticides (OCPs) in breast milk and the related health risks for women in Taiwan. Our goal is to examine breast milk OCPs and their associations with female reproductive function (infertility, gynecological diseases, and menstruation characteristics) as well as their correlation with sociodemographic parameters (age, pre-pregnant body mass index (BMI), annual incomes, population, birth year, and parity) and dietary habit. The breast milk samples were collected in southern Taiwan (n = 68) from 2013 to 2016 and the OCP residues were analyzed using high resolution gas chromatography with low resolution mass spectrometry (HRGC/LRMS). The results show that the most abundant OCP residues in the breast milk was ΣDDT with the geometric mean ± standard deviation of 9.81 ± 7.52 ng−1 lipid−1 followed by ΣHCH (0.539 ± 0.557 ng−1·lipid−1). In the principal component analysis, cis-chlordane (cis-CHL) and γ-HCH were found to be related to participants who received medical treatment for infertility, and 4,4′-DDT was associated with those who received gynecological surgery. The logistic regression showed that the odds ratio (OR) of log γ-hexachlorocyclohexane (γ-HCH) was higher for mothers who had received medical treatment for infertility than for the normal group (OR = 25.6, p = 0.035) after adjustments for age, pre-pregnant BMI, annual income, population (i.e., native-born Taiwanese), birth year, and parity. Cow milk and beef consumption as well as menstruation characteristics such as average menstrual period (>5 days), shortest menstrual period (<3 days), and women who had taken hormonal drugs were significantly associated to several OCP residues in the breast milk. In addition, ΣHCH including β-HCH and γ-HCH was correlated with annual family income and gravidity as well as cow milk and beef consumptions. Overall, γ-HCH exhibited a probable association with the infertility diseases of Taiwanese women, and dietary habit might play an important role in the female Taiwanese exposure to OCPs.

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Section: Introductionmentioning

confidence: 99%

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Chen

Santos

Que

et al. 2018

IJERPH

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“…He reported that IRS was associated with elevated serum DDT/DDE and urinary pyrethroid metabolite concentrations in peripartum samples collected from 751 VHEMBE women 24,25 . Associations between maternal exposure to DDT and hypertensive disorders of pregnancy 26 , larger birth size 27 , and higher body composition measures, and marginally altered motor development were found among VHEMBE girls at age 1 and/or 2 years 28 . Prenatal exposure to pyrethroids was also associated with lower body composition measures among boys 28 and altered motor development among girls aged 1 to 3.5 years 29,30 .…”

Section: Nutrition and Toxicodietary Exposuresmentioning

confidence: 86%

“…Associations between maternal exposure to DDT and hypertensive disorders of pregnancy 26 , larger birth size 27 , and higher body composition measures, and marginally altered motor development were found among VHEMBE girls at age 1 and/or 2 years 28 . Prenatal exposure to pyrethroids was also associated with lower body composition measures among boys 28 and altered motor development among girls aged 1 to 3.5 years 29,30 . Given these results and the widespread exposure to these insecticides in African populations, the VHEMBE study has also provided education and outreach to many of the participants to reduce exposure.…”

Section: Nutrition and Toxicodietary Exposuresmentioning

confidence: 86%

Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop

et al. 2019

Self Cite

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Individuals with African ancestry have extensive genomic diversity but have been underrepresented in genomic research. There is also extensive global diversity in the exposome (the totality of human environmental exposures from conception onwards) which should be considered for integrative genomic and environmental health research in Africa. To address current research gaps, we organized a workshop on environmental health research in Africa in conjunction with the H3Africa Consortium and the African Society of Human Genetics meetings in Kigali, Rwanda. The workshop was open to all researchers with an interest in environmental health in Africa and involved presentations from experts within and outside of the Consortium. This workshop highlighted innovative research occurring on the African continent related to environmental health and the interplay between the environment and the human genome. Stories of success, challenges, and collaborative opportunities were discussed through presentations, breakout sessions, poster presentations, and a panel discussion. The workshop informed participants about environmental risk factors that can be incorporated into current or future epidemiology studies and addressed research design considerations, biospecimen collection and storage, biomarkers for measuring chemical exposures, laboratory strategies, and statistical methodologies. Inclusion of environmental exposure measurements with genomic data, including but not limited to H3Africa projects, can offer a strong platform for building gene-environment (G x E) research in Africa. Opportunities to leverage existing resources and add environmental exposure data for ongoing and planned studies were discussed. Future directions include expanding the measurement of both genomic and exposomic risk factors and incorporating sophisticated statistical approaches for analyzing high dimensional G x E data. A better understanding of how environmental and genomic factors interact with nutrition and infection is also needed. Considering that the environment represents many modifiable risk factors, these research findings can inform intervention and prevention efforts towards improving global health.

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“…Emerging evidence suggests that many endocrinedisrupting pesticides have effects on cardiometabolic outcomes (Azandjeme et al, 2013). For example, DDT concentration has been consistently and positively associated with body composition and body weight in young girls, and DDT and DDE were found to be associated with elevated risk of hypertensive disorders in pregnancy (Coker et al, 2018;Murray et al, 2018), while chronic exposure of non-diabetic farmers to organophosphorus malathion pesticides appears to induce insulin resistance (Raafat et al, 2012). One study examined a variety of biochemical effects of pesticides including hematological profile, lipid parameters, serum markers of nephrotoxicity and hepatotoxicity, as well as the activities of butyryl cholinesterase (BChE), acetylcholinesterase (AChE), and thiolactonase-paroxonase (PON).…”

Section: Pesticides Health Outcomesmentioning

confidence: 99%

Environmental Health Research in Africa: Important Progress and Promising Opportunities

Joubert

Mantooth²,

McAllister

2020

Front. Genet.

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The World Health Organization in 2016 estimated that over 20% of the global disease burden and deaths were attributed to modifiable environmental factors. However, data clearly characterizing the impact of environmental exposures and health endpoints in African populations is limited. To describe recent progress and identify important research gaps, we reviewed literature on environmental health research in African populations over the last decade, as well as research incorporating both genomic and environmental factors. We queried PubMed for peer-reviewed research articles, reviews, or books examining environmental exposures and health outcomes in human populations in Africa. Searches utilized medical subheading (MeSH) terms for environmental exposure categories listed in the March 2018 US National Report on Human Exposure to Environmental Chemicals, which includes chemicals with worldwide distributions. Our search strategy retrieved 540 relevant publications, with studies evaluating health impacts of ambient air pollution (n=105), indoor air pollution (n = 166), heavy metals (n = 130), pesticides (n = 95), dietary mold (n = 61), indoor mold (n = 9), per-and polyfluoroalkyl substances (PFASs, n = 0), electronic waste (n = 9), environmental phenols (n = 4), flame retardants (n = 8), and phthalates (n = 3), where publications could belong to more than one exposure category. Only 23 publications characterized both environmental and genomic risk factors. Cardiovascular and respiratory health endpoints impacted by air pollution were comparable to observations in other countries. Air pollution exposures unique to Africa and some other resource limited settings were dust and specific occupational exposures. Literature describing harmful health effects of metals, pesticides, and dietary mold represented a context unique to Africa. Studies of exposures to phthalates, PFASs, phenols, and flame retardants were very limited. These results underscore the need for further focus on current and emerging environmental and chemical health risks as well as better integration of genomic and environmental factors in African research studies. Environmental exposures with distinct routes of exposure, unique co-exposures and co-morbidities, combined with the extensive genomic diversity in Africa may lead to the identification of novel mechanisms underlying complex disease and promising potential for translation to global public health.

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Association between prenatal exposure to multiple insecticides and child body weight and body composition in the VHEMBE South African birth cohort

Cited by 169 publications

References 65 publications

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Association between Organochlorine Pesticide Levels in Breast Milk and Their Effects on Female Reproduction in a Taiwanese Population

Integrating environmental health and genomics research in Africa: challenges and opportunities identified during a Human Heredity and Health in Africa (H3Africa) Consortium workshop

Environmental Health Research in Africa: Important Progress and Promising Opportunities

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