Association between prepartum body condition score and prepartum and postpartum dry matter intake and energy balance in multiparous Holstein cows

Casaro, S.; Pérez-Báez, J.; Bisinotto, R.S.; Chebel, R.C.; Prim, J.G.; Gonzalez, T.D.; Carvalho Gomes, G.; Tao, S.; Toledo, I.M.; do Amaral, B.C.; Bollati, J.M.; Zenobi, M.G.; Martinez, N.; Dahl, G.E.; Santos, J.E.P.; Galvão, K.N.

doi:10.3168/jds.2023-24047

Cited by 1 publication

(3 citation statements)

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“…According to the directionality network, the prepartum immune and metabolic status of cows were impacted by their ppBW. In dairy cows, body weight is strongly correlated with body condition score (BCS), a measure of subcutaneous adiposity [11], hence, we speculate that heavier cows were fatter. The greater ppBW in cows that developed metritis negatively impacted the prepartum Live cells and the BWC leading to heavier cows experiencing more cell death and greater BW loss.…”

Section: Discussionmentioning

confidence: 96%

“…Elevated systemic ROS levels cause cell death [24]. Furthermore, cows with greater BCS experience a more pronounced negative nutrient balance prior to parturition, leading to greater BW loss [11]. The greater cell death observed in cows that developed metritis led to an increase in prepartum PMN.…”

Section: Discussionmentioning

confidence: 99%

“…It is not clear why these opportunistic pathogens thrive and cause metritis; however, the metabolic and immune changes associated with parturition and the onset of lactation seem to play an important role in metritis development [9,10]. Around parturition, cows that develop metritis experience a period of negative nutrient balance [4], which is more pronounced in overconditioned cows [11]. This period of negative nutrient balance leads to lesser blood calcium [12], lesser amino acids [13], and greater circulating fatty acids concentration [10].…”

Section: Introductionmentioning

confidence: 99%

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Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis

Casaro,

Prim,

Gonzalez

et al. 2024

Preprint

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Background Cows that develop metritis experience dysbiosis of their uterine microbiome, where opportunistic pathogens overtake uterine commensals. Whether opportunistic pathogens thrive and cause metritis may be determined by how efficiently the immune system responds to these pathogens. Nonetheless, periparturient cows experience immune dysregulation, which seems to be intensified by prepartum obesity and lipid mobilization Herein, Bayesian networks were applied to investigate the directional correlations between prepartum body weight (BW), BW loss, pre- and postpartum systemic immune profiling and plasma metabolome, and postpartum uterine metabolome and microbiome. Results According to the directionality network, greater prepartum BW led to greater BW loss, which led to an increase in plasma fatty acids at parturition, indicating that heavier cows were in lower energy balance than lighter cows. Greater prepartum BW also led to an increase in prepartum systemic cellular death, which led to an increase in systemic inflammation, immune activation, and metabolomic changes associated with oxidative stress prepartum and at parturition, which indicates a positive directional correlation between BW and systemic inflammation. These changes led to an increase in polymorphonuclear cell extravasation postpartum, which led to an increase in uterine metabolomic changes associated with tissue damage, suggesting that excessive polymorphonuclear cell migration to the uterus leads to excessive endometrial damage. These changes led to an increase in pathogenic bacteria in cows that developed metritis, suggesting that excessive tissue damage may disrupt physical barriers or increase substrate availability for bacterial growth. Conclusions This work provides robust mechanistic hypotheses for how prepartum body weight impacts peripartum immune and metabolic profiles, leading to uterine opportunistic pathogens overgrowth and metritis development.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis

Casaro,

Prim,

Gonzalez

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

Association between prepartum body condition score and prepartum and postpartum dry matter intake and energy balance in multiparous Holstein cows

Cited by 1 publication

References 42 publications

Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis

Multi-omics integration and immune profiling identify possible causal networks leading to uterine microbiome dysbiosis in dairy cows that develop metritis

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