Association between prescribing hypnotics for parents and children in Norway

Holdø, Ingvild; Handal, Marte; Bramness, Jørgen G.

doi:10.1136/archdischild-2013-303646

Cited by 10 publications

(11 citation statements)

References 28 publications

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“…Since 2004, use of alimemazine has almost halved in 0–17 year olds, attributed to a decrease among 1–2 year olds in particular, in whom use decreased more than threefold. Alimemazine is licensed and has long been used for childhood insomnia in Norway [ 15 , 16 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…The systemic antihistamine alimemazine is licensed in Norway for use as a supplement to behavioural therapy in childhood insomnia for children aged 2 years and older, and has been available on the market in Norway since 1975 [ 21 ]. It has for a long time been prescribed relatively frequently to young children for sleep problems [ 15 , 16 , 22 ]. It is on this basis that alimemazine was included.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Psychotropic drug use among 0–17 year olds during 2004–2014: a nationwide prescription database study

Hartz¹,

Skurtveit

Steffenak³

et al. 2016

BMC Psychiatry

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BackgroundTime-trend studies on psychotropic drugs among children and adolescents are scarce, and most of them are outdated. The purpose of this study was to study prevalences of psychotropic drug use during 2004–2014 among Norwegians aged <18 years, overall and in psychotropic sub-groups.MethodsData were obtained from the Norwegian Prescription Database, which covers all dispensed prescription drugs in Norway from 2004 and onwards. Psychotropic drugs included: antipsychotics (ATC-group N05A), anxiolytics (N05B), hypnotic/sedatives (N05C), antidepressants (N06A), stimulants (N06BA), and alimemazine (R06AD01). Period (1-year) prevalence of use, overall and in subgroups of psychotropic drugs, was estimated by identifying individuals <18 years who had at least one psychotropic drug dispensed during each year.ResultsPsychotropic drug use increased in 0–17 year olds over an 11-year period, in which the main contributing drugs were stimulants (boys overall; 15.0 to 20.8/1000, girls overall; 3.8 to 8.5/1000), hypnotic/sedative drugs in adolescents (boys overall; 4.2 to 10.8/1000, girls overall; 2.6 to 8.8/1000) and to some extent antidepressants among adolescent girls (girls overall from 3.1 to 4.0/1000). Psychotropic drug use was, however, reduced by half in the youngest children, attributed to reduction of alimemazine only (1-year olds: boys; from 36.6 to 10.2/1000, girls; 26.9 to 7.2/1000). A higher level of psychotropic drug use was observed among younger boys, but there is a shift towards girls using more psychotropic drugs than boys during adolescence for all psychotropic drugs except for stimulants.ConclusionDifferent trends in psychotropic drug use exist in age and gender subgroups. Psychotropic drug use has decreased among the youngest children, attributed to alimemazine, and increased in older children and adolescents, attributed mainly to stimulants and hypnotics/sedatives.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Psychotropic drug use among 0–17 year olds during 2004–2014: a nationwide prescription database study

Hartz¹,

Skurtveit

Steffenak³

et al. 2016

BMC Psychiatry

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“…However, the clinical trials supporting these specific indications could not be located. Case reports described significant morbidity15 23–25 in children of 4 years and younger after alimemazine use and intoxication. All case reports were published more than 10 years ago.…”

Section: Resultsmentioning

confidence: 99%

Are antihistamines effective in children? A review of the evidence

et al. 2016

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“…The following psychotropic drugs were investigated: stimulants (ATC code N06B); antiepileptics (N03A), antidepressants (N06A), antipsychotics (N05A), anxiolytics (N05B), hypnotics (N05C), alimemazine (R06AD01). Alimemazine is used in Norway as a hypnotic, particularly to children (18). Pain relievers as opioids (N02A), NSAIDS (M01A) and prescription paracetamol (N02BE01) were also investigated, but not presented in the tables because of low prevalence of use.…”

Section: The Norwegian Prescription Database (Norpd)mentioning

confidence: 99%

Nationwide Study of Neuropsychiatric Comorbidity and Medicines Use in Children With Autism Spectrum Disorder in Norway

et al. 2020

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Purpose: Autism spectrum disorder (ASD) has a high rate of comorbidity. While many children with ASD are exposed to psychotropic medicines, their efficacy and safety in these patients are unclear. There is a need for more detailed knowledge on which medicines are most commonly used and for which disorders. We aimed to investigate (a) prevalence and incidence rate of ASD among Norwegian children, and further, among newly diagnosed ASD children in 2014, study the (b) co-occurrence of neuropsychiatric disorders, (c) use of psychotropic drugs, and (d) the relationship between co-occurring diagnoses and use of psychotropic drugs.Method: Nationwide registry-based study of children 2–17 years old in Norway.Results: The ASD prevalence was 0.76% and the incidence rate was 0.12% in 2014. Of the children who received an initial ASD diagnosis in 2014 (n = 1,234), 64.8% had one or more co-occurring neuropsychiatric diagnosis. Psychotropic medication use was moderate (~20% used stimulants or hypnotics) in general, and low in children without comorbidity (nearly only hypnotics). There was a good accordance between co-occurring diagnoses and indication for the prescribed medications.Conclusions: Children with newly diagnosed ASD mainly received psychotropic drugs to treat co-occurring neuropsychiatric conditions.

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Association between prescribing hypnotics for parents and children in Norway

Cited by 10 publications

References 28 publications

Psychotropic drug use among 0–17 year olds during 2004–2014: a nationwide prescription database study

Psychotropic drug use among 0–17 year olds during 2004–2014: a nationwide prescription database study

Are antihistamines effective in children? A review of the evidence

Nationwide Study of Neuropsychiatric Comorbidity and Medicines Use in Children With Autism Spectrum Disorder in Norway

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