Association between prognostic factors and clinical outcome of well-differentiated thyroid carcinoma: A retrospective 10-year follow-up study

Abstract

Abstract. Differentiated thyroid carcinoma (DTC) is one of the most common metabolic disorders and accounts for 98% of all cases of thyroid cancer. Previously, a number of studies have investigated the prognostic factors associated with well-differentiated thyroid carcinoma (WDTC); however, these studies yielded conflicting results. The current study used a retrospective study design to collect data from WDTC patients who had received the same treatment regimen from the same institute, with a minimum follow-up of 10 years. The De Groot staging system was used to classify WDTC in a total of 320 patients (240 females and 80 males). Among the subjects, the pathological subtypes identified were as follows: Papillary carcinoma (240 cases, 75%), follicular carcinoma (67 cases, 21%) and Hürthle cell carcinoma (13 cases, 4%). Prognostic factors that significantly affected the clinical outcome of the disease were advanced age (P=0.001), tumor size (P=0.03), presence of thyroglobulin (P=0.001) and De Groot stage (P=0.005). The 10-year follow-up study revealed that WDTC is associated with a high survival rate of 96% (307/320 patients survived) and a low mortality rate (4%).

Morphological features of radioiodine-resistance metastases of thyroid papillary carcinoma

“…An interesting phenomenon of the absence of FS in the histological material of RIRM (except for 1 case), when they are registered in 14% of punctures of RIRM can be explained by the fact that when conducting a FNAPB RIRM, even single follicles, which do not mark histologists, can enter into the punctate. According to literature, tumor necrosis factor is one of the most important histologic markers of poorly differentiated PC and an independent predictor of survival of the patient, even when the histologic tumor architecture corresponds to a well-differentiated PC [14]. At the same time, we did not find a statistically significant difference in the frequency of occurrence in the histological material of such signs as NC and OC between the study groups of tumors.…”

“…So, four years after the Chernobyl disaster, the incidence of thyroid cancer in children increased by 4.8 times, and in subsequent years exceeded the accident rate by 10 times [3,9,23]. However, in contrast to carcinoma of other localizations, differentiated thyroid cancer in most cases has a favorable prognosis: the survival 5-year rate of patients with thyroid cancer is about 98%, and 20-30 years of survival exceeds 90% [10,14,15]. The key to successful treatment of differentiated thyroid cancer and its metastases is the use of radioiodine therapy, a specific highly effective, targeted method of treating this disease.…”

Significance of changes in general clinical analysis of blood and thyroid status in people with neoplasm of the thyroid gland

“…На відміну від карцином інших локалізацій, рак щитоподібної залози при своєчасному виявленні і правильному лікуванні має сприятливий прогноз, і 20-30-річна виживаність перевищує 90 % [4,5].…”

Ультразвукові Та Цитологічні Характеристики Радіойодчутливості Метастазів Папілярного Раку Щитоподібної Залози

“…Через 4 роки після Чорнобильської катастрофи частота захворювань на рак ЩЗ у дітей збільшилась у 4,8 раза, а наступними роками перевищила передаварійні показники в 10 разів [3,4]. Але, на відміну від карцином інших локалізацій, диференційований рак ЩЗ у більшості випадків має сприятливий прогноз -летальні випадки фіксують досить зрідка (в 4-6% випадків), 5-річне виживання хворих становить близько 98%, а 20-30-річне -перевищує 90% [5][6][7]. Дуже високими є й показники безрецидивного 10-20-30-річного виживання -понад 70%, 60% і 50% відповідно [8,9].…”