Association Between Red Blood Cell Distribution Width-to-Albumin Ratio and Prognosis of Patients with Aortic Aneurysms

Long, Jianyun; Xie, Xueqin; Xu, Dong; Huang, Chang-Pin; Liu, Yongchang; Meng, Xiaohu; Cai, Xuchao; Fang, Xin

doi:10.2147/ijgm.s328035

Cited by 32 publications

(28 citation statements)

References 27 publications

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“…According to reports, low serum albumin on admission for AMI was an independent predictor of cardiovascular death events. 3 RDW-albumin ratio (RAR) was associated with the prognosis of aortic aneurysms, 4 diabetic ketoacidosis, 5 cancer 6 and heart failure (HF). 7 It could be a critical metric for assessing criticality scores in cardiovascular disease.…”

Section: Introductionmentioning

confidence: 99%

Association of Red Blood Cell Distribution Width-Albumin Ratio for Acute Myocardial Infarction Patients with Mortality: A Retrospective Cohort Study

Ruan

2022

Clin Appl Thromb Hemost

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Background Red blood cell distribution width (RDW) was a risk factor for poor prognosis in acute myocardial infarction (AMI). Recent reports suggested that combining RDW with other laboratory metrics could provide a better prediction. This retrospective study aimed to investigate whether the RDW-albumin ratio (RAR) may be associated with mortality after an AMI. Methods This cohort study was conducted among adults (over 16 years old) with AMI in the Medical Information Mart for Intensive Care Database III V1.4 (MIMIC-III). The primary outcome was 30-day mortality, and the secondary outcome was 1-year and 3-year mortality. Cox hazard regression model and Kaplan–Meier survival curves were constructed to estimate the effect of biomarkers on mortality. We used three models to adjust for potential bias. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were analyzed for the excellent performance of RAR on prognosis. Results A total of 826 patients were eventually enrolled in our study. In multivariate analysis, RAR was found to be associated with 30-day mortality (Model 3: HR = 1.23, 95% CI = 1.09-1.39, P < .001). In addition, Subgroup analysis showed that the effect of RAR was higher in female patients than in male patients ( P for interaction = .026). Kaplan-Meier survival curves showed that patients in the lower RAR quartile tended to have higher survival rates in the short and long term. AMI patients with RAR ≥ 4 had a 122% increase in 3-year mortality. Results of ROC and AUC showed that the prognostic performance of RAR for mortality was the best (30-day mortality: 0.703; 1-year mortality: 0.729; 3-year mortality: 0.737). Conclusions RAR is a simple and stable predictor of prognosis in AMI patients. Our results support RAR = 4.0 as a criterion for prognostic risk stratification of AMI patients.

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Section: Introductionmentioning

confidence: 99%

Association of Red Blood Cell Distribution Width-Albumin Ratio for Acute Myocardial Infarction Patients with Mortality: A Retrospective Cohort Study

Ruan

2022

Clin Appl Thromb Hemost

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“…Recently, many studies have been conducted with the idea that RAR may provide better results in determining the prognosis of diseases compared to the individual evaluation of either parameter in this ratio [ 13 - 15 ]. We conducted the current study for the same purpose, and to our knowledge, our study is the first to determine the predictive ability of RAR in the prognosis of ABP.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of the Red Cell Distribution Width/Albumin Ratio in the Prediction of the Severity of Acute Biliary Pancreatitis: A Preliminary Report

Dönmez¹,

Ayata²

2022

Cureus

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Objective Acute pancreatitis (AP) is a common inflammatory disease that should be considered in the etiology of patients presenting to the emergency department with abdominal pain. AP manifests with a clinical picture that can lead to organ failure and even death; therefore, early diagnosis and treatment are essential. In this study, we aimed to evaluate the red cell distribution width (RDW)/albumin ratio (RAR), which, we consider, can be used to determine the clinical course of acute biliary pancreatitis (ABP). Material and method The study included 166 patients with ABP. The patient's demographic information, blood values at the time of the first presentation to the emergency department, and radiological results were recorded by screening them retrospectively. Using the Atlanta criteria, the cases were classified into mild, moderately severe, and severe AP groups (MAP, MSAP, and SAP, respectively) and compared. Results Of the patients, 121 (72.9%) patients had MAP, 40 (24.1%) had MSAP, and five (3%) had SAP. There was no statistically significant difference between the three groups regarding gender and age. The SAP group had significantly higher median values for the length of hospital stay [19 (4-31) days], white blood cell (WBC) count [20.4 x10 9 /L (9.1-23.3 x10 9 /L)], and creatinine (Cre) [1.4 mg/dL (0.7-3.4 mg/dL)] (p<0.001, p=0.003, and p=0.014, respectively). The RDW and albumin values of all the groups were within normal ranges. RAR was higher in the SAP group but did not statistically significantly different between the groups. In the receiver operating characteristic (ROC) analysis of RAR, the area under the curve (AUC) value was determined as 0.75, sensitivity as 80%, specificity as 70.2%, and positive likelihood ratio as 2.1 (p=0.05). Conclusion It is considered that RAR may be a helpful method in determining the course of ABP attacks, but there is a need for studies with a larger series, including all pancreatitis cases.

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“… 20 Albumin not only exerts anti‐inflammatory effects but also reduces oxidative stress and inhibits apoptosis of endothelial cells. 21 , 22 The RDW‐to‐albumin (RA) ratio is a novel inflammatory biomarker, 23 which has previously been used to assess the prognosis of patients with stroke 22 and aortic aneurysms. 23 , 24 We hypothesized that the use of RDW in combination with albumin may be a potential predictor of cancer mortality.…”

Section: Introductionmentioning

confidence: 99%

“… 21 , 22 The RDW‐to‐albumin (RA) ratio is a novel inflammatory biomarker, 23 which has previously been used to assess the prognosis of patients with stroke 22 and aortic aneurysms. 23 , 24 We hypothesized that the use of RDW in combination with albumin may be a potential predictor of cancer mortality. In the present study, we assessed the prognostic value RA ratio in predicting cancer mortality.…”

Section: Introductionmentioning

confidence: 99%

Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients

Lu¹,

Long

Liu³

et al. 2022

Clinical Laboratory Analysis

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Background: Cancer causes a serious health burden on patients worldwide. Chronic low-level inflammation plays a key role in tumorigenesis and prognosis. However, the role of the red blood cell distribution width (RDW)-to-albumin (RA) ratio in cancer mortality remains unclear. Methods:In this retrospective cohort study, we collected clinical information from cancer patients from the Medical Information Mart for Intensive Care III (MIMIC-III) version 1.4 database and then calculated RA by dividing RDW by albumin concentration. The primary outcome was 30 days mortality, while secondary outcomes were 90 days and 1 year mortality. Next, we adopted Cox regression models to calculate hazard ratios (HR) together with 95% confidence intervals (CI) for all-cause mortalities associated with the RA ratio.Results: For 30 days mortality, the HR (95% CI) for the high RA ratio (≥5.51) was 2.17 [95CI% (1.87-2.51); p = <0.0001], compared with the low RA ratio (<5.51). In Model 2, we adjusted sex and age and obtained HR (95% CI) of 2.17 [95CI% (1.87-2.52); p = <0.0001] for the high RA ratio (≥5.51) group, compared to that in the low RA ratio (<5.51). In Model 3, adjusting for age, sex, anion gap, hematocrit, white blood cell count, congestive heart failure, SOFA, liver disease, and renal failure resulted in HR (95% CI) of 1. ; p = <0.0001] for the high RA ratio (≥5.51) relative to the low RA ratio (<5.51). We also analyzed common diseases in cancer patients but found no significant association. Conclusion:To the best of our knowledge, this is the first study demonstrating that increased RA ratio is independently associated with increased all-cause mortality in cancer patients.

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Association Between Red Blood Cell Distribution Width-to-Albumin Ratio and Prognosis of Patients with Aortic Aneurysms

Cited by 32 publications

References 27 publications

Association of Red Blood Cell Distribution Width-Albumin Ratio for Acute Myocardial Infarction Patients with Mortality: A Retrospective Cohort Study

Association of Red Blood Cell Distribution Width-Albumin Ratio for Acute Myocardial Infarction Patients with Mortality: A Retrospective Cohort Study

Prognostic Significance of the Red Cell Distribution Width/Albumin Ratio in the Prediction of the Severity of Acute Biliary Pancreatitis: A Preliminary Report

Red blood cell distribution width‐to‐albumin ratio is associated with all‐cause mortality in cancer patients

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