Association between red blood cell distribution width and disease activity in patients with Behçet’s disease

Aksoy, Şefika; Savaş, Esen; Sucu, Murat; Kısacık, Bünyamin; Kül, Seval; Zengin, Orhan

doi:10.1177/0300060515591063

Cited by 25 publications

(24 citation statements)

References 25 publications

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“…Behçet's disease is chronic inflammatory disease. Therefore there were some studies in which high CRP and ESR levels were calculated [24]. In this study, ESR and albumin levels were high in BD group.…”

Section: Discussionmentioning

confidence: 70%

Relationship between QT dispersion and biochemical parameters in Behçet’s disease

Altuntaş¹,

Nazik²,

Gül³

et al. 2019

Ortadogu Tıp Derg

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Objective: Ventricular arrhythmia and sudden cardiac death are more frequently in Behçet's disease (BD) patients than normal population. Therefore in this study it was aimed to find out relationship among QT dispersion, Behçet's disease and biochemical parameters related with disease. Material and Method: The study consisted of 35 patients which diagnosed Behçet's disease (BD) according to international diagnose criteria and 47 healthy controls which were matched with regard to age and gender. 12-channel surface electrocardiography (ECG) was performed to all participants. QT distances, corrected QT (QTc) distances which is calculated by using Bazett formula were calculated. The longest QT, and the shortest QT, the longest QTc, the shortest QTc were found in the ECG. Afterwards QTd and QTcd were calculated. Blood samples were taken from participants after 12 hours fasting. Findings: The groups were compared in terms of the longest QT-QTc, the shortest QT-QTc, QTd, QTcd. It was seen that there was meaningful difference in terms of the longest QT and QTc (respectively p; 0.004; 0.018). Mean platelet volume (MPV) and albumin were higher in control group while erythrocyte sedimentation rate (ESR) was higher in BH group (respectively p; 0.000; 0,000; 0,002). Additionally there was negative correlation among the longest QT-QTc and ESR, albumin, but there was established positive correlation between the longest QT-QTc and MPV. Statistical results were presented in table 2-3-4. Conclusion: Consequently in this study, it was established that the longest QT and QTc was increased and there was relationship between biochemical parameters and the longest QT-QTc.

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Section: Discussionmentioning

confidence: 70%

Relationship between QT dispersion and biochemical parameters in Behçet’s disease

Altuntaş¹,

Nazik²,

Gül³

et al. 2019

Ortadogu Tıp Derg

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“…[21] Several studies have been published regarding the relationship between RDW and inflammatory disease. RDW can be used as a novel potential parameter to evaluate disease activity in inflammatory bowel disease, Behçet disease, and systemic lupus erythematosus, [11,22,23] and RDW was correlated with inflammatory parameters such as CRP, ESR, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6). [23–25] Oxidative stress, which might be effective in damaging erythrocyte membrane, perturbing normal energy metabolism in erythrocytes, and reducing erythrocyte life span, [26] was also reported to be associated with RDW.…”

Section: Discussionmentioning

confidence: 99%

Association between red blood cell distribution width and Henoch–Schonlein purpura nephritis

Xu¹,

Li²,

Mao

et al. 2017

Medicine

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To investigate whether red blood cell distribution width (RDW) is a marker of the risk of Henoch–Schonlein purpura (HSP) nephritis (HSPN), a total of 669 HSP patients and 168 healthy controls were included in this retrospective study. Two hundred fifty-six (38.3%) of the patients had kidney involvement. Compared with the HSP group, RDW was significantly higher in the HSPN group (P < .001). Binary logistic regression identified that HSPN was independently associated with age, RDW, platelet, and total cholesterol (odds ratio = 1.409, 1.353, 0.996, and 2.019, respectively). In addition, RDW values of HSPN patients with crescents on histopathology (classes III, IV, and V) were higher compared with those of HSPN without crescents (classes I and II) (P = .019). The receiver–operating characteristic curve analysis showed that the RDW at a cut-off point of 13.25 has 61% sensitivity and 79% specificity in predicting the presence of crescents on histopathology. It was first shown that RDW levels in HSPN are significantly higher than those in HSP without nephritis and healthy controls. RDW can be an independent predictor of HSPN and its levels greater than 13.25 were useful in the predicting the presence of crescents on histopathology.

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“…1 Division of Rheumatology, Allergy and Immunology, Taoyuan City, Taiwan, Republic of China; 2 Center fo big data analytics and statistics, Taoyuan City, Taiwan, Republic of China Background: Previous studies have reported an increased risk of multiple comorbidities in people with RA therefore it is necessary to systematically quantify the comorbidity burden of these patients. [1] The comorbidity index is a tool developed under this concept and has multiple clinical and research uses. Objectives: We compared four comorbidity indexes and mortality rate in patients with rheumatoid arthritis in Taiwan (Charlson Comorbidity Index (CCI), Elixhauser Comorbidity Index (ECI), Mutimorbidity index (MMI), Rheumatic Disease Comorbidity Index (RDCI)) Methods: All patients with rheumatoid arthritis diagnosed during 1998-2008 in Taiwan were identified using the Taiwan National Health Insurance Database and followed up to 31 Dec 2013.…”

Section: Ab0259mentioning

confidence: 99%

Ab0258 potential Role of Mean Platelet Volume and Red Blood Cell Distribution Width as a Biomarker for Clinical and Sonographic Activity in Rheumatoid Arthritis Patients

Hassan

Elhanafi

Eltanawy

et al. 2019

Abstracts Accepted for Publication

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BackgroundRed cell distribution width (RDW) reflects the variation in the circulating erythrocytes size (anisocytosis) that can increase in chronic inflammation due to ineffective erythropoiesis [1], while mean platelet volume (MPV) reveals the average size of platelets and may disclose its activation. Both are typically included in the complete blood count (CBC) and have been studied as a possible indicator of disease activity in many inflammatory conditions [2].ObjectivesThis study aimed to assess the relationship between MPV and RDW levels and various rheumatoid arthritis (RA) clinical,laboratory and ultrasongraphic disease activity parameters in patients with recent onset RA before and after initiation of therapy.MethodsWe assessed MPV and RDW in blood samples obtained from 60 recent onset RA patients and 30 healthy controls at baseline and 4 months after initiation therapy with non-biological disease modifying anti-rheumatic drugs (DMARDS). Disease activity was calculated using the 28 joint counts (DAS28) and musculoskeletal ultrasound examination (MSUS) was performed at baseline and after 4 months using a 12-joint score (bilateral elbow, wrist, 2nd metacarpophalangeal (MCP), 3rd MCP, knee, ankle) [2]; Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels, rheumatoid factor (RF) titre and anti-cyclic citrullinated peptide (anti-CCP) antibodies titre were measured and the health assessment questionnaire (HAQ) score was documented.ResultsBaseline RDW was significantly increased in RA (15.16 ± 3.63%) compared to its level in the healthy controls (12.16 ± 1.43%) (p<0.001). While, there was no significant difference in MPV between RA and control groups (10.92 ± 2.02 fl and 10.08 ± 0.88 fl respectively) (p=0.2).In RA patients, baseline RDW significantly correlated with CRP(r=0.39, p<0.05), DAS28 (r=0.47, p<0.05), grey scale (GS) (r=0.53, p<0.05) and power Doppler (PD) (r=0.56, p<0.001) synovitis scores. Also, RDW at 4 months follow up significantly correlated with the DAS28 (r =0.42, p<0.05), GS score (r=0.45, p<0.05). MPV showed no significant correlation with clinical, laboratory and ultrasonographic parameter of RA disease activity.Baseline RDW (p =0.02) was shown to be comparable to ESR (p =0.03) but less than CRP (p =0.001) at predicting PD synovitis score.ConclusionRheumatoid arthritis patients have significantly increased RDW levels that remarkably correlated with clinical, laboratory and MSUS parameters of inflammations suggesting that it could be a useful marker to reflect RA disease activity. RDW could be a useful biomarker to predict treatment outcome in RA patient. In this regard, MPV had poor correlations.References[1] Aksoy ŞN, Savaş E, Sucu M, Kisacik B, Kul S, Zengin O. Association between red cell distribution width and disease activity in patients with Behçet’s disease. J Int Med Res. 2015Dec;43(6):765-73.[2] Tecer D, Sezgin M, Kanık A, İncel NA, çimen öB, Biçer A, Şahin G. Can mean platelet volume and red blood cell distribution width show disease activity in rheumatoid arthritis?...

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Association between red blood cell distribution width and disease activity in patients with Behçet’s disease

Cited by 25 publications

References 25 publications

Relationship between QT dispersion and biochemical parameters in Behçet’s disease

Relationship between QT dispersion and biochemical parameters in Behçet’s disease

Association between red blood cell distribution width and Henoch–Schonlein purpura nephritis

Ab0258 potential Role of Mean Platelet Volume and Red Blood Cell Distribution Width as a Biomarker for Clinical and Sonographic Activity in Rheumatoid Arthritis Patients

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