Association between red blood cell transfusions and development of non-Hodgkin lymphoma: a meta-analysis of observational studies

Abstract

The incidence of non-Hodgkin lymphoma (NHL) has increased steadily for the past few decades. Previous studies have suggested an association between blood transfusions and NHL.

Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding

“…A meta-analysis summarizing these reports found an increased risk for NHL in cohort studies. 15 The risk was significantly higher for CLL/small lymphocytic lymphoma than other NHL subtypes (relative risk 5 1.66; 95% CI, 1.08-2.56). 15 Based on these findings, the investigators recommended a conservative approach to blood transfusion needs.…”

“…15 The risk was significantly higher for CLL/small lymphocytic lymphoma than other NHL subtypes (relative risk 5 1.66; 95% CI, 1.08-2.56). 15 Based on these findings, the investigators recommended a conservative approach to blood transfusion needs. 15 Knowledge of the potential of n/a n/a n/a n/a n/a n/a .00 n/a n/a n/a n/a n/a n/a .00 n/a n/a n/a n/a n/a n/a In conclusion, we demonstrated a much higher prevalence of MBL in blood donors than previously reported.…”

“…5,10 MBL has been detected in donated blood, 4 and a recent metaanalysis suggests that blood transfusions may be associated with an increased risk for developing B-cell malignancies. 15 However, a systematic study of MBL prevalence in blood donors using sensitive and specific laboratory methods is lacking.…”

Management of Anemia in Cancer Patients: Transfusions

“…In a subset analysis, the RR for chronic lymphocytic leukemia/small lymphocytic lymphoma was 1.66 (95% CI, 1.08 -2.56) [25].…”

Transfusion and NHL risk: a meta-answer?

“…F lorence Sabin, the first woman to be elected to the American National Academy of Sciences, needed no more than a primitive microscope and chicken embryos kept alive in culture to conclude in 1917 the existence of a unique origin for both emerging endothelial and blood cells. 1 The term hemangioblast was coined 15 years later to name such progenitors, but did not gain wide popularity until the end of the 20th century when the existence of angiohematopoietic stem cells became one of the most challenging concepts in developmental hematology. Sabin's brilliant intuition was confirmed when hemangioblasts were identified among the progeny of mouse and human embryonic stem cells 2,3 and in early mouse and fish embryos.…”