Association Between Relapsing Polychondritis and Systemic Lupus Erythematosus

Auricular chondritis and thrombotic microangiopathy: An unusual combination revealing systemic lupus erythematosus

“…The most frequent were rheumatoid arthritis (n = 7), myeloproliferative diseases (n = 4), systemic lupus erythematosus (n = 3) and vasculitis (n = 3). The literature data are scarce, but it is known that chondritis can appear before or after the emergence of lupus [3][4][5][6]. Antinuclear antibodies are detected in 25% of cases of polychondritis [1] but in the present case, the high levels of anti-DNA antibodies and low complement levels were highly suggestive of a diagnosis of lupus.…”

A Case of Polychondritis in a Patient with Behçet's Disease

“…In patients with RP, the antibodies to collagen type II, IX and XI are elevated in the sera15, 16) and the frequency of human leukocyte antigen (HLA)-DR4 is increased17). Additionally, RP has been associated with other autoimmune diseases such as RA and SLE9, 10). In patients with BD, autoantibodies such as antiendothelial cell antibody and antibody to α-tropomyosin have been found18-20) and it has been postulated that cross-reactivity and molecular mimicry between the peptides from the streptococcal proteins or the viral heat shock proteins (HSPs), which are homologues of human HSPs, and the mucosal antigens result in the selection of autoreactive T cells21).…”

Antiphospholipid syndrome with complete abdominal aorta occlusion and chondritis

“…1,3,4 Chondritis or relapsing polychondritis is seen in fewer than 1% of patients with SLE. [5][6][7] On the other hand, arterial and venous thrombosis in relapsing polychondritis is not rare, and is usually attributed to underlying vasculitis, [8][9][10] unlike thrombosis in APS without vasculitis. 2,11 However, thrombosis in the absence of vasculitis in a patient with relapsing polychondritis was found to have lupus anticoagulant.…”