Association between reported medication adherence and health-related quality of life in adult patients with haemophilia

Adherence to prophylactic treatment in adult patients with severe hemophilia in Poland

“…After childhood, adherence declines with age [27,28]. However, a recent study showed an increase in adherence in elderly patients (≥60 years) compared with those aged 20-59 years [29]. We found no statistically significant differences in the total scores between age groups, although patients aged 50-59 scored slightly lower than all other age groups.…”

“…Another Spanish population study conducted only on adult patients showed higher adherence rate of 82.5% [28]. The adherence rate in our study was also higher than obtained for the Croatian/Slovenian population (83%) [29], but comparable to that for the German patients with hemophilia (93.1%) [30].…”

Treatment Adherence and Health-Related Quality of Life in Patients with Hemophilia in Hong Kong

“…Poor treatment adherence was correlated with impairment in specific aspects of HRQoL. Although the overall association between adherence and HRQoL was not significant in the multivariable analysis, the benefits of treatment adherence in improving health and psychosocial outcomes in patients with hemophilia are well documented in the literature [ 15 , 17 , 18 , 31 , 48 ]. In addition to improving functional outcomes, one Chinese study also showed that the suboptimal use of coagulation factor concentrates was associated with higher direct medical cost and healthcare use [ 49 ].…”

“…Univariate analyses were performed using the Mann–Whitney U test (for categorical variables) and Spearman’s correlation test (for continuous variables) to compare differences in study outcomes between patients in different subgroups. The variables included in this study were clinical and socioeconomic factors that have been were hypothesized in the literature to affect HRQoL or adherence: (1) The clinical factors included age as a continuous variable, as well as disease severity (mild-to-moderate versus severe) and treatment type (prophylactic treatment versus on-demand therapy) as categorical variables [ 6 , 7 , 17 , 24 , 31 ]. (2) The socioeconomic factors included housing type (public housing versus private housing) and the highest educational attainment of adult patients and of the parents of pediatric patients (secondary school and below versus post-secondary) as categorical variables [ 17 , 18 , 31 , 32 ].…”

“…Despite the advantages of prophylactic clotting factors, studies have reported a low adherence to home-based therapy in patients with hemophilia, due to significant barriers and perceived limitations [ 9 , 15 , 16 ], including infusion pain, difficulty with venous access and the time-consuming nature of the procedure [ 9 , 15 , 16 ]. Better treatment adherence was a significant predictor of less bodily pain and better social functioning in patients with hemophilia [ 17 , 18 ]. These findings collectively suggest that more attention should be paid to identifying patients with hemophilia who are non-adherent to medication.…”