Association Between Reported Use of Inhaled Triamcinolone and Differential Short-term Responses to Aerosolized Albuterol in Asthmatics in an Emergency Department Setting

Inhaled budesonide in the management of acute worsenings and exacerbations of asthma: A review of the evidence

“…One study has suggested that ICS might enhance b 2 -agonist responsiveness. 22 ICS have thus attracted attention as a potential alternative to systemic therapy in acute asthma.…”

Interactions between corticosteroids and beta agonists

“…Recently, Aziz et al have shown that downregulation of human heart rate responses to salbutamol during treatment with the long acting β agonist formoterol was modified by concomitant use of inhaled steroid 42. Likewise, cardiovascular responses to emergency β agonist drugs may be increased in patients who have previously received treatment with inhaled corticosteroids 43. In contrast, in healthy volunteers the use of oral prednisone failed to potentiate the effects of β agonist on heart rate or QTc interval 44.…”

Nebulized therapy with suspension of budesonide in exacerbations of asthma and chronic obstructive pulmonary disease

“…Доказательством данной гипотезы могут слу жить результаты исследования I.Aziz и B.J.Lipworth, согласно которым «болюс» ингаляционного буде сонида в дозе 1,6 мг уже в течение 2 ч приводит к восстановлению бронхопротективного эффекта β2 агонистов и восстановлению чувствительности β 2 рецепторов у больных, принимавших β 2 агонисты длительного действия [40]. В исследовании R.Y.Lin et al также было показано, что терапия иГКС усили вает бронхорасширяющий эффект β 2 агонистов [41].…”