Association between resting amygdalar activity and abnormal cardiac function in women and men: a retrospective cohort study

Fiechter, Michael; Roggo, A; Burger, Irene A.; Bengs, Susan; Treyer, Valérie; Becker, Anton S.; Marędziak, Monika; Haider, Ahmed; Portmann, Angela; Messerli, Michael; Patriki, Dimitri; Mühlematter, Urs Jakob; Felten, Elia von; Benz, Dominik C.; Fuchs, Tobias A.; Gräni, Christoph; Pazhenkottil, Aju P.; Buechel, Ronny R.; Kaufmann, Philipp A.; Gebhard, Cathérine

doi:10.1093/ehjci/jez047

Cited by 31 publications

(60 citation statements)

References 33 publications

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“…Similarly, PET imaging was used to demonstrate the effects of steroidal hormone-mediated signaling on brain function and behavior in psychiatric disorders, such as anxiety and depression [16]. Another example is the association of metabolic activity of the resting-state amygdala with abnormal cardiac function and perfusion in women, thus, suggesting a link between emotional stress and cardiovascular disease [17]. However, all of these studies focused on imaging the brain and not the target organ eventually impacted, the heart.…”

Section: Metabolic Syndrome As An Exemplar Of Applied Systems Biologymentioning

confidence: 99%

Applied Systems Biology—embracing molecular imaging for systemic medicine

Hacker

Hicks

Beyer

2020

Eur J Nucl Med Mol Imaging

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Section: Metabolic Syndrome As An Exemplar Of Applied Systems Biologymentioning

confidence: 99%

Applied Systems Biology—embracing molecular imaging for systemic medicine

Hacker

Hicks

Beyer

2020

Eur J Nucl Med Mol Imaging

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“…It provides incremental prognostic information and enables personalized anti-neoplastic therapy [3,4]. Consequently, 18 F-FDG-PET/CT is considered the standard of care for various tumor entities, as it improves cancer outcomes and reduces unnecessary surgeries and thus complications [5].…”

Section: Introductionmentioning

confidence: 99%

“…In addition to its established role in oncology, PET/CT imaging has significantly improved clinical decision-making in patients with known or suspected coronary artery disease (CAD) [6][7][8][9][10][11]. Although cardiovascular and oncologic 18 F-FDG-PET/CT imaging procedures are similar, there are critical differences in patient preparation protocols. While cardiovascular 18 F-FDG-PET/CT has been validated to assess myocardial viability and cardiac inflammation, it remains unknown whether oncologic 18 F-FDG-PET/CT can identify patients at risk for cardiovascular disease [12][13][14][15].…”

Section: Introductionmentioning

confidence: 99%

“…Although cardiovascular and oncologic 18 F-FDG-PET/CT imaging procedures are similar, there are critical differences in patient preparation protocols. While cardiovascular 18 F-FDG-PET/CT has been validated to assess myocardial viability and cardiac inflammation, it remains unknown whether oncologic 18 F-FDG-PET/CT can identify patients at risk for cardiovascular disease [12][13][14][15]. However, a timely and cost-effective risk stratification of cancer patients is crucial given that cardiotoxicity represents the most critical complication of anti-cancer treatments [16].…”

Section: Introductionmentioning

confidence: 99%

“…Given the routine use of 18 F-FDG-PET/CT in oncology, identifying a high-risk 18 F-FDG-PET/CT myocardial uptake pattern would allow for the referral of vulnerable patients to further cardiovascular assessment. Thus, we investigated the value of myocardial 18 F-FDG uptake pattern to predict cardiovascular risk in patients undergoing oncologic 18 F-FDG-PET/CT.…”

Section: Introductionmentioning

confidence: 99%

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Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT

Haider

Bengs

Schade

et al. 2020

JCM

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Objective: Positron emission tomography/computed tomography with 18F-fluorodeoxy-glucose (18F-FDG-PET/CT) has become the standard staging modality in various tumor entities. Cancer patients frequently receive cardio-toxic therapies. However, routine cardiovascular assessment in oncologic patients is not performed in current clinical practice. Accordingly, this study sought to assess whether myocardial 18F-FDG uptake patterns of patients undergoing oncologic PET/CT can be used for cardiovascular risk stratification. Methods: Myocardial 18F-FDG uptake pattern was assessed in 302 patients undergoing both oncologic whole-body 18F-FDG-PET/CT and myocardial perfusion imaging by single-photon emission computed tomography (SPECT-MPI) within a six-month period. Primary outcomes were myocardial 18F-FDG uptake pattern, impaired myocardial perfusion, ongoing ischemia, myocardial scar, and left ventricular ejection fraction. Results: Among all patients, 109 (36.1%) displayed no myocardial 18F-FDG uptake, 77 (25.5%) showed diffuse myocardial 18F-FDG uptake, 24 (7.9%) showed focal 18F-FDG uptake, and 92 (30.5%) had a focal on diffuse myocardial 18F-FDG uptake pattern. In contrast to the other uptake patterns, focal myocardial 18F-FDG uptake was predominantly observed in patients with myocardial abnormalities (i.e., abnormal perfusion, impaired LVEF, myocardial ischemia, or scar). Accordingly, a multivariate logistic regression identified focal myocardial 18F-FDG uptake as a strong predictor of abnormal myocardial function/perfusion (odds ratio (OR) 5.32, 95% confidence interval (CI) 1.73–16.34, p = 0.003). Similarly, focal myocardial 18F-FDG uptake was an independent predictor of ongoing ischemia and myocardial scar (OR 4.17, 95% CI 1.53–11.4, p = 0.005 and OR 3.78, 95% CI 1.47–9.69, p = 0.006, respectively). Conclusions: Focal myocardial 18F-FDG uptake seen on oncologic PET/CT indicates a significantly increased risk for multiple myocardial abnormalities. Obtaining and taking this information into account will help to stratify patients according to risk and will reduce unnecessary cardiovascular complications in cancer patients.

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Neuroimaging Findings From Cerebral Structure and Function in Coronary Artery Disease

Wang,

Zhang,

Lyu

et al. 2024

Magnetic Resonance Imaging

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An increasing number of evidence suggests that bidirectional communication between the cardiovascular system and the central nervous system (CNS), known as the heart–brain interaction, is crucial in understanding the impact of coronary artery disease (CAD) on brain health. The multifactorial role of CAD in the brain involves processes such as inflammation, oxidative stress, neuronal activity, neuroendocrine imbalances, and reduced cerebral perfusion, leading to various cerebral abnormalities. The mechanisms underlying the relationship between CAD and brain injury are complex and involve parallel pathways in the CNS, endocrine system, and immune system. Although the exact mechanisms remain partially understood, neuroimaging techniques offer valuable insights into subtle cerebral abnormalities in CAD patients. Neuroimaging techniques, including assessment of neural function, brain metabolism, white matter microstructure, and brain volume, provide information on the evolving nature of CAD‐related cerebral abnormalities over time. This review provides an overview of the pathophysiological mechanisms of CAD in the heart–brain interaction and summarizes recent neuroimaging studies utilizing multiparametric techniques to investigate brain abnormalities associated with CAD. The application of advanced neuroimaging, particularly functional, diffusion, and perfusion advanced techniques, offers high resolution, multiparametric capabilities, and high contrast, thereby allowing for the early detection of changes in brain structure and function, facilitating further exploration of the intricate relationship between CAD and brain health.Level of Evidence5Technical EfficacyStage 3

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Association between resting amygdalar activity and abnormal cardiac function in women and men: a retrospective cohort study

Cited by 31 publications

References 33 publications

Applied Systems Biology—embracing molecular imaging for systemic medicine

Applied Systems Biology—embracing molecular imaging for systemic medicine

Myocardial 18F-FDG Uptake Pattern for Cardiovascular Risk Stratification in Patients Undergoing Oncologic PET/CT

Neuroimaging Findings From Cerebral Structure and Function in Coronary Artery Disease

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