Association between retinal vascular measures and brain white matter lesions in schizophrenia

Korann, Vittal; Suhas, Satish; Appaji, Abhishek; Nagendra, Bhargavi; Padmanabha, Ananth; Jacob, Arpitha; Devi, Priyanka; Bharath, Rose Dawn; Kumar, Vijay; Varambally, Shivarama; Venkatasubramanian, Ganesan; Rao, Shyam Vasudeva; Webers, Caroll; Berendschot, Tos T. J. M.; Rao, Naren P.

doi:10.1016/j.ajp.2022.103042

Cited by 6 publications

(2 citation statements)

References 64 publications

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“…And WML is also seen in schizophrenia [43][44][45][46][47] and alcohol related psychiatric disorder [48][49][50][51][52][53] .…”

Section: Inference Of Mechanismsmentioning

confidence: 99%

Plasma Phosphoethanolamine Levels as a Biomarker for Monitoring Major Depressive Disorder

Kawamura,

Nakata,

Harada

et al. 2023

Preprint

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This study is the first to identify a promising candidate monitoring biomarker for major depressive disorder (MDD), plasma phosphoethanolamine (PEA) concentrations. A naturalistic observational study in clinical psychiatry was conducted with Japanese subjects between 2011 and 2020. Out of the 576 patients, 295 had depressive disorders, 264 had psychiatric disorders other than depression, and 17 had physical disorders without psychiatric disorders. In 170 patients with MDD only, in whom remission was easily identified, plasma PEA levels were measured at two or more time points. These levels dropped significantly in depressive episodes, increased as remission approached and were significantly higher in remission. Psychiatric diagnosis alone explained 38% of the variance in plasma PEA concentrations. Receiver operating characteristic (ROC) curve analysis also showed sufficient discriminatory power to detect depression, with an area under the curve (AUC) of 0.84 (95% confidence interval (CI): 0.80-0.87). Further researches are needed.

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“…And WML is also seen in schizophrenia [43][44][45][46][47] and alcohol related psychiatric disorder [48][49][50][51][52][53] .…”

Section: Inference Of Mechanismsmentioning

confidence: 99%

Plasma Phosphoethanolamine Levels as a Biomarker for Monitoring Major Depressive Disorder

Kawamura,

Nakata,

Harada

et al. 2023

Preprint

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“…Endothelial Dysfunction (ED) has been described as a risk factor and mechanism in itself of the development of CVD [23,24]. In particular, the chronic inflammatory response [25] and the increased vasoconstriction [26] and oxidative stress [27] have attracted great interest in the relationship between CVD and SZ [28]. Regarding the diagnostic classification of patients, in relation to this problem, Geriatric Psychiatrists have published a review of the Conference of the International Late-Onset Schizophrenia Group.…”

Section: Introductionmentioning

confidence: 99%

Vascular Schizophrenia-like Psychosis in Older Adults

Lauriola,

D’Onofrio,

Ciccone

et al. 2023

JCM

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Background: The aims of this study were to analyze prevalence and severity of vascular risk factors in older patients referred to our clinic due to onset of Very Late-Onset Schizophrenia-Like Psychosis (VLOSLP) and to create a specific phenotype based on pathophysiological insight rather than age of onset. Methods: In a longitudinal study, 103 (M = 39, F = 64; mean age of 80.32 ± 7.65 years) patients were evaluated with cognitive, neuropsychiatric, and functional assessment scales. Blood concentration of hemoglobin (Hb), mean corpuscular volume (MCV), platelets, total protein test (TPT), creatinine, azotemia, glycemia, total cholesterol (TC), triglycerides (TG), uric acid (UA), sodium (Na), potassium (K), chlorine (Cl), calcium (Ca), folate, vitamin B12 (Vit-B12), and homocysteine were measured. Presence/absence of tobacco use, alcohol consumption, psychoactive substance use, hypertension, hyperlipidemia, diabetes mellitus, and history of vascular disease were collected. Results: Females were more apathetic than males (NPI-Apathy: p = 0.040). Males had a significantly higher level of Hb (p = 0.019) and UA (p = 0.001), and a lower level of platelets (p = 0.004) and Ca (p = 0.003), and used more tobacco (p = 0.046) and alcohol (p = 0.024) than females. Comparing patients < 80 and ≥80 years, we found differences in frequency of vascular risk factors among men (p = 0.027). In total, 102 patients were treated for psychosis (59.16% of them were using atypical antipsychotics). Conclusions: The results of this study could be useful for a progressive demonstration of the causal relationship between cardiac and cerebral vascular events and VLOSLP.

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Retinal microvasculature in schizophrenia: A meta-analysis with trial sequential analysis of studies assessing vessel density using Optical Coherence Tomography Angiography

Janti

Tikka

2023

Asian Journal of Psychiatry

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Association between retinal vascular measures and brain white matter lesions in schizophrenia

Cited by 6 publications

References 64 publications

Plasma Phosphoethanolamine Levels as a Biomarker for Monitoring Major Depressive Disorder

Plasma Phosphoethanolamine Levels as a Biomarker for Monitoring Major Depressive Disorder

Vascular Schizophrenia-like Psychosis in Older Adults

Retinal microvasculature in schizophrenia: A meta-analysis with trial sequential analysis of studies assessing vessel density using Optical Coherence Tomography Angiography

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