Association between sarcopenia and cognitive impairment in community-dwelling population

Zhu, Haiyan; Li, Heng-Dong; Feng, Bobo; Zhang, Lu; Zheng, Zaixing; Zhang, Yue; Wang, Dongjuan; Xiong, Zi; Kang, Junfei; Jin, Jia-Chang; Lin, Jie; Ye, Honghua

doi:10.1097/cm9.0000000000001310

Cited by 5 publications

(7 citation statements)

References 6 publications

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“…The total number of included participants was not equal to the sum of the numbers of males and females because some studies only provided the total numbers and did not separate participants into males and females. Two studies only included females [ 28 , 29 ], one study only included males [ 30 ], and the others were all mixed gender [ 20 – 27 , 31 – 45 ]. The point prevalence of sarcopenia ranged from 4.48 to 50.84%.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of sarcopenia in Chinese community-dwelling elderly: a systematic review

Ren

Zhang

et al. 2022

BMC Public Health

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Background Sarcopenia is associated with age-related loss of muscle mass and function and is becoming prevalent in the older Chinese population. This systematic review aims to obtain a reliable estimation of the prevalence of sarcopenia among community-dwelling Chinese populations aged 65 years and older and to characterize its epidemiology. Methods A literature search was performed in the Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, and CQVIP databases up to September 31, 2021. All studies that reported the prevalence of sarcopenia in Chinese community-dwelling older adults were included, and Hoy et al.’s tool was used to assess the risk of bias. The overall prevalence of sarcopenia will be calculated as the primary outcome, and subgroup analyses will be performed by study year, age, sex, muscle mass assessment method, diagnostic criteria and area. Results A total of 26 studies were included in this study, which involved 25,921 subjects, and 3597 had sarcopenia. Although significant heterogeneity between studies was reported, no statistically significant publication bias was detected. The overall prevalence of sarcopenia in community-dwelling older adults aged over 65 years in the Chinese population was 17.4% (95% CI: 14.6%-20.2%). Subgroup analysis based on study year, age and sex, muscle mass assessment method, diagnostic criteria, region and area showed that the prevalence of sarcopenia was different in each subgroup. Implications The prevalence of sarcopenia in Chinese community-dwelling older adults was higher than that in previous studies. As a multidimensional survey of the prevalence of sarcopenia in older adults, this meta-analysis provides data support for the targeted management of sarcopenia among Chinese older adults.

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Section: Resultsmentioning

confidence: 99%

Prevalence of sarcopenia in Chinese community-dwelling elderly: a systematic review

Ren

Zhang

et al. 2022

BMC Public Health

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“…Additionally, sarcopenia has a strong interaction with cognitive decline. [53] Sarcopenia is manifested in two aspects: muscle mass loss and muscle dysfunction [Figure 3]. Muscle mass loss includes three pathways: malnutrition, mechanical stress deficiency, and neuroendocrine disorder.…”

Section: General Pathogenesis Of Frailtymentioning

confidence: 99%

“…Weight loss, poor grip strength, slow walking speed, and reduced daily activity are all associated with sarcopenia. Additionally, sarcopenia has a strong interaction with cognitive decline [53] . Sarcopenia is manifested in two aspects: muscle mass loss and muscle dysfunction [Figure 3].…”

Section: Possible Pathogenesis Of Frailty In Kt Candidates and Recipi...mentioning

confidence: 99%

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Frailty in kidney transplant candidates and recipients: pathogenesis and intervention strategies

Cao

Zhang

Sun

et al. 2023

Chinese Medical Journal

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With the rapid aging of the global population posing a serious problem, frailty, a non-specific state that reflects physiological senescence rather than aging in time, has become more widely addressed by researchers in various medical fields. A high prevalence of frailty is found among kidney transplant (KT) candidates and recipients. Therefore, their frailty has become a research hotspot in the field of transplantation. However, current studies mainly focus on the cross-sectional survey of the incidence of frailty among KT candidates and recipients and the relationship between frailty and transplantation. Research on the pathogenesis and intervention is scattered, and relevant review literature is scarce. Exploring the pathogenesis of frailty in KT candidates and recipients and determining effective intervention measures may reduce waiting list mortality and improve the long-term quality of life of KT recipients. Therefore, this review explains the pathogenesis and intervention measures for frailty in KT candidates and recipients to provide a reference for the formulation of effective intervention strategies.

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“…Patients with sarcopenia not only suffer from a loss of muscle strength but also face mobility impairments that reduce their quality of life. As a result, they are at higher risk of morbidity (falls, fractures, and metabolic diseases) and mortality [5,6,13] . Sarcopenia often occurs in obese patients and is called sarcopenic obesity [14] .…”

Section: What Is Sarcopenia?mentioning

confidence: 99%

Role of adipokines in sarcopenia

Feng

Lai

et al. 2023

Chinese Medical Journal

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Sarcopenia is an age-related disease that mainly involves decreases in muscle mass, muscle strength and muscle function. At the same time, the body fat content increases with aging, especially the visceral fat content. Adipose tissue is an endocrine organ that secretes biologically active factors called adipokines, which act on local and distant tissues. Studies have revealed that some adipokines exert regulatory effects on muscle, such as higher serum leptin levels will cause a decrease in muscle function and adiponectin inhibits the transcriptional activity of Forkhead box O3 (FoxO3) by activating peroxisome proliferators-activated receptor-γ coactivator -1α (PGC-1α) and sensitizing cells to insulin, thereby repressing atrophy-related genes (atrogin-1 and muscle RING finger 1 [MuRF1]) to prevent the loss of muscle mass. Here, we describe the effects on muscle of adipokines produced by adipose tissue, such as leptin, adiponectin, resistin, mucin and lipocalin-2, and discuss the importance of these adipokines for understanding the development of sarcopenia.

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Association between sarcopenia and cognitive impairment in community-dwelling population

Cited by 5 publications

References 6 publications

Prevalence of sarcopenia in Chinese community-dwelling elderly: a systematic review

Prevalence of sarcopenia in Chinese community-dwelling elderly: a systematic review

Frailty in kidney transplant candidates and recipients: pathogenesis and intervention strategies

Role of adipokines in sarcopenia

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