Association between Sarcopenia and Immediate Complications and Mortality in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgery

Huang, Chun-Hou; Lue, Kun-Han; Chen, Peir-Rorg; Hsieh, Tsung-Cheng; Chou, Yu-Fu

doi:10.3390/cancers14030785

Cited by 12 publications

(12 citation statements)

References 77 publications

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“…In our study, the SCI-E database was used to obtain information on publications on the relationship between The relationship between sarcopenia and surgery was still a concern and discussed topic in recent years due to the significant roles played by sarcopenia in surgical procedures, as well as the prognosis after surgeries (24,25). A study that enrolled 480 older patients with gastrointestinal and hepatobiliary pancreatic tumors showed that patients with poor muscle strength may have poor outcomes after their first resection surgeries (26).…”

Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Liu

Song

et al. 2023

Front. Surg.

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BackgroundThe relationship between sarcopenia and surgery has attracted an increasing number of researchers in recent years. Our study aimed to identify the current research hotspot and status in this field by using bibliometric and visualization analysis.MethodsPublications about the relationship between sarcopenia and surgery that met the inclusion criteria were collected from the Science Citation Index Expanded. The bibliometric and visualized studies were performed using VOSviewer, and R.ResultsA total of 2,261 documents on the relationship between sarcopenia and surgery were included in our study. These articles were written by 13,757 authors from 2,703 institutions in 70 countries and were published in 772 journals. The USA is the most productive and influential country in this field (524 publications and 15,220 citations). The Udice French Research Universities was the most productive institution in this field (57 publications), and the University of Alberta had the largest number of citations. Annuals of Surgical Oncology published the most studies in this field. Shen Xian was the most productive author in this field (number of publications = 19), and Baracos Vickie was the most influential author, whose studies in this field had been cited 2,209 times. The cluster analysis was performed and visualized, and the keywords were classified into 6 clusters: Cluster 1 (body composition and nutrition), Cluster 2 (sarcopenia), Cluster 3 (malnutrition and cachexia), Cluster 4 (cancer surgery), Cluster 5 (elderly and frailty), Cluster 6 (neuromuscular scoliosis).ConclusionThe relationship between sarcopenia and surgery was still a controversial and well-discussed topic in recent years. Our study showed that the study in this field mainly focused on sarcopenia, oncology surgery, orthopedics, and nutrition.

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Section: Discussionmentioning

confidence: 99%

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Liu

Song

et al. 2023

Front. Surg.

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Section: Discussionmentioning

confidence: 99%

“…High SII levels have been reported to be associated with postoperative complications of oral cavity squamous cell carcinoma and ovarian peritoneal carcinomatosis. 21 , 22 Xie et al 23 first discovered that the combination of tumor markers and SII was a significant predictor of postoperative complications for patients after colorectal surgery. Based on the research by Xie, 23 this study further demonstrated that patients with the cutoff value of SII > 916.99 were more proven to have symptomatic AL than those without.…”

Section: Discussionmentioning

confidence: 99%

Serum and peritoneal biomarkers for the early prediction of symptomatic anastomotic leakage in patients following laparoscopic low anterior resection: A single‐center prospective cohort study

Tan

Liu

et al. 2023

Cancer Reports

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Background Anastomotic leakage (AL) is one of the common complications after rectal cancer surgery. This study aimed to evaluate the combination of biomarkers for the early prediction of symptomatic AL after surgery. Methods A prospective cohort study evaluated the serum and peritoneal biomarkers of patients who underwent laparoscopic low anterior resection (Lap LAR) from November 1, 2021, to May 1, 2022. Multivariate‐penalized logistic regression was performed to explore the independent biomarker with a P‐value <.1, and receiver operating characteristic (ROC) curve was used to analyze the area under the curve (AUC), sensitivity, and specificity of the independent biomarkers. A predictive model for symptomatic AL was built based on the independent biomarkers and was visualized with a nomogram. The calibration curve with the concordance index (c‐index) was further applied to evaluate the efficacy of the predictive model. Results A total of 157 patients were included in this study, and 7 (4.5%) were diagnosed with symptomatic AL. C‐reactive protein/album ratio (CAR) on postoperative day 1 and systemic immune‐inflammation index (SII) and peritoneal interleukin‐6 (IL‐6) on postoperative day 3 were proven to be independent predictors for the early prediction of symptomatic AL. The optimal cutoff values of CAR, SII, and peritoneal IL‐6 were 1.04, 916.99, and 26430.09 pg/ml, respectively. Finally, the nomogram, including these predictors, was established, and the c‐index of this nomogram was 0.812, indicating that the nomogram could be used for potential clinical reference. Conclusion The combination of CAR, SII, and peritoneal IL‐6 might contribute to the early prediction of symptomatic AL in patients following Lap LAR. Given the limitations of this study and the emergence of other novel biomarkers, multicenter prospective studies are worthy of further exploration.

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“…For example, a higher SII was reported as a distinct prognostic indicator of OSCC in certain articles ( 19 , 26 , 28 ). In contrast, some researchers indicated the absence of any obvious association of SII with survival outcomes in OSCC ( 23 – 25 ). Consequently, to identify the precise impact of SII on predicting OSCC prognosis, this work carried out comprehensive literature retrieval for meta-analysis.…”

Section: Introductionmentioning

confidence: 95%

Prognostic and clinicopathological role of pretreatment systemic immune-inflammation index in patients with oral squamous cell carcinoma: a meta-analysis

Zhang,

Dai

2024

Front. Oncol.

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BackgroundThere are many studies regarding the use of systemic immune-inflammation index (SII) to help predict oral squamous cell carcinoma (OSCC) prognosis, but findings have been inconsistent. The present meta-analysis was conducted to determine whether SII could contribute to predicting OSCC prognosis.MethodsPubMed, Embase, Cochrane Library and Web of Science databases were thoroughly searched from their inceptions through August 20, 2023. The role of SII in predicting OSCC prognosis was determined through combined hazard ratios (HRs) with relevant 95% confidence intervals (CIs). Correlations of SII with clinicopathological characteristics of OSCC patients were analyzed based on combined odds ratios (ORs) with 95% CIs.ResultsThis meta-analysis utilized 11 articles in total, involving 3,464 patients. According to the results, an elevated SII was markedly associated with dismal overall survival (OS) (HR=1.85, 95%CI=1.48-2.29, p<0.001) and poor disease-free survival (DFS) (HR=1.77, 95%CI=1.20-2.61, p=0.004) of OSCC. Moreover, a higher SII was markedly correlated with stage T3-T4 (OR=2.47, 95%CI=1.40-4.37, p=0.002), TNM stage III-IV (OR=2.29, 95%CI=1.53-3.44, p<0.001), and low differentiation (OR=1.74, 95%CI=1.25-2.43, p=0.001).ConclusionAccording to the present meta-analysis, an increased SII is significantly associated with dismal OS and DFS, advanced tumor stage and poor differentiation in OSCC. SII could be a potential and important biomarker for clinical management and predicting the prognosis of patients with OSCC.Systematic review registrationhttps://inplasy.com/inplasy-2023-9-0033/), identifier INPLASY202390033.

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Association between Sarcopenia and Immediate Complications and Mortality in Patients with Oral Cavity Squamous Cell Carcinoma Undergoing Surgery

Cited by 12 publications

References 77 publications

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Bibliometric analysis of research trends in relationship between sarcopenia and surgery

Serum and peritoneal biomarkers for the early prediction of symptomatic anastomotic leakage in patients following laparoscopic low anterior resection: A single‐center prospective cohort study

Prognostic and clinicopathological role of pretreatment systemic immune-inflammation index in patients with oral squamous cell carcinoma: a meta-analysis

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