Association between sarcopenia and prognosis of hepatocellular carcinoma: A systematic review and meta-analysis

Jiang, Chuan; Wang, Yanyan; Fu, Wei; Zhang, Guozhuan; Xu, Feng; Wang, Xing; Wang, Fang; Zhang, Le; Deng, Yang

doi:10.3389/fnut.2022.978110

Cited by 17 publications

(11 citation statements)

References 88 publications

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“…The mechanism is complex, but it is well established that chronic liver disease can trigger muscle atrophy and structural changes in skeletal muscle, and skeletal muscle compartments contribute to the progression of liver disease (20). In addition, muscle loss leads to insulin resistance and increases the activity of IGF-1, which can regulate hepatocyte proliferation (21).…”

Section: Discussionmentioning

confidence: 99%

The combination of hand grip strength and modified Glasgow prognostic score predicts clinical outcomes in patients with liver cancer

et al. 2023

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PurposePrevious studies have shown that both hand grip strength (HGS) and the modified Glasgow Prognostic Score (mGPS) are associated with poor clinical outcomes in patients with liver cancer. In spite of this, no relevant studies have been conducted to determine whether the combination of HGS and mGPS can predict the prognosis of patients with liver cancer. Accordingly, this study sought to explore this possibility.MethodsThis was a multicenter study of patients with liver cancer. Based on the optimal HGS cutoff value for each sex, we determined the HGS cutoff values. The patients were divided into high and low HGS groups based on their HGS scores. An mGPS of 0 was defined as low mGPS, whereas scores higher than 0 were defined as high mGPS. The patients were combined into HGS-mGPS groups for the prediction of survival. Survival analysis was performed using Kaplan–Meier curves. A Cox regression model was designed and adjusted for confounders. To evaluate the nomogram model, receiver operating characteristic curves and calibration curves were used.ResultsA total of 504 patients were enrolled in this study. Of these, 386 (76.6%) were men (mean [SD] age, 56.63 [12.06] years). Multivariate analysis revealed that patients with low HGS and high mGPS had a higher risk of death than those with neither low HGS nor high mGPS (hazard ratio [HR],1.50; 95% confidence interval [CI],1.14–1.98; p = 0.001 and HR, 1.55; 95% CI, 1.14–2.12, p = 0.001 respectively). Patients with both low HGS and high mGPS had 2.35-fold increased risk of death (HR, 2.35; 95% CI, 1.52–3.63; p < 0.001). The area under the curve of HGS-mGPS was 0.623. The calibration curve demonstrated the validity of the HGS-mGPS nomogram model for predicting the survival of patients with liver cancer.ConclusionA combination of low HGS and high mGPS is associated with poor prognosis in patients with liver cancer. The combination of HGS and mGPS can predict the prognosis of liver cancer more accurately than HGS or mGPS alone. The nomogram model developed in this study can effectively predict the survival outcomes of liver cancer.

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Section: Discussionmentioning

confidence: 99%

The combination of hand grip strength and modified Glasgow prognostic score predicts clinical outcomes in patients with liver cancer

et al. 2023

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“…Up to 30%-40% of HCC patients are affected by sarcopenia at the time of diagnosis, at least partially because of the pro-inflammatory state triggered by the altered tumor microenvironment[ 45 ]. As sarcopenia influences the response to surgical, locoregional, and systemic treatments, its timely recognition is essential.…”

Section: Prevalence and Role Of Sarcopenia Across Liver Diseasesmentioning

confidence: 99%

Quick and easy assessment of sarcopenia in cirrhosis: Can ultrasound be the solution?

Campani,

Li Cavoli,

Arena

et al. 2024

World J Gastroenterol

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Cirrhosis is frequently associated with sarcopenia, with reported rates of over 80% in patients with decompensated alcohol-related liver disease. Sarcopenia negatively impacts the prognosis of cirrhotic patients and affects the response to treatment of patients with hepatocellular carcinoma (HCC). For these reasons, identifying an easy-to-perform method to assess sarcopenia in is a key element in the optimization of care in this patient population. Assessment of muscle mass by computed tomography is considered the standard of care for the diagnosis of sarcopenia, but exposure to radiation and high costs limit its application in this setting, especially for repeated assessments. We believe that ultrasound, a cheap and harmless technique also used for HCC screening in cirrhotic patients, could have an expanding role in the diagnosis and follow-up of sarcopenia in these patients.

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“…Each domain was judged as low, moderate, or high risk of bias, according to published criteria [17]. The overall risk of bias for an included study was defined as low risk with ≥ 4 low-and no high-risk domains, moderate risk with < 4 low-and no highrisk domains, and high risk with ≥ 1 high-risk domain [18].…”

Section: Assessment Of Risk Of Biasmentioning

confidence: 99%

Does paraspinal muscle morphometry predict functional status and re-operation after lumbar spinal surgery? A systematic review and meta-analysis

Han

Dai

et al. 2023

Eur Radiol

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Objectives Whether paraspinal muscle degeneration is related to poor clinical outcomes after lumbar surgery is still indistinct, which limits its clinical application. This study aimed to evaluate the predictive value of paraspinal muscle morphology on functional status and re-operation after lumbar spinal surgery. Methods A review of the literature was conducted using a total of 6917 articles identified from a search of PubMed, EMBASE, and Web of Science databases through September 2022. A full-text review of 140 studies was conducted based on criteria including an objective assessment of preoperative paraspinal muscle morphology including multifidus (MF), erector spinae (ES), and psoas major (PS) in addition to measuring its relationship to clinical outcomes including Oswestry disability index (ODI), pain and revision surgery. Meta-analysis was performed when required metrics could be calculated in ≥ three studies, otherwise vote counting model was a good alternative to show the effect direction of evidence. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated. Results A total of 10 studies were included in this review. Of them, five studies with required metrics were included in the meta-analysis. The meta-analysis suggested that higher preoperative fat infiltration (FI) of MF could predict higher postoperative ODI scores (SMD = 0.33, 95% CI 0.16–0.50, p = 0.0001). For postoperative pain, MF FI could also be an effective predictor for persistent low back pain after surgery (SMD = 0.17, 95% CI 0.02–0.31, p = 0.03). However, in the vote count model, limited evidence was presented for the prognostic effects of ES and PS on postoperative functional status and symptoms. In terms of revision surgery, there was conflicting evidence that FI of MF and ES could predict the incidence of revision surgery in the vote count model. Conclusion The assessment of MF FI could be a viable method to stratify patients with lumbar surgery by the risk of severe functional disability and low back pain. Key Points • The fat infiltration of multifidus can predict postoperative functional status and low back pain after lumbar spinal surgery. • The preoperative evaluation of paraspinal muscle morphology is conducive for surgeons.

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Association between sarcopenia and prognosis of hepatocellular carcinoma: A systematic review and meta-analysis

Cited by 17 publications

References 88 publications

The combination of hand grip strength and modified Glasgow prognostic score predicts clinical outcomes in patients with liver cancer

The combination of hand grip strength and modified Glasgow prognostic score predicts clinical outcomes in patients with liver cancer

Quick and easy assessment of sarcopenia in cirrhosis: Can ultrasound be the solution?

Does paraspinal muscle morphometry predict functional status and re-operation after lumbar spinal surgery? A systematic review and meta-analysis

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