Association between Schistosomiasis mansoni and hepatitis C: systematic review

Van-Lume, Daniele Silva de Moraes; Albuquerque, Maria de Fátima Pessoa Militão de; Souza, Ariani Impieri de; Domingues, Ana Lúcia Coutinho; Lopes, Edmundo Pessoa; Morais, Clarice Neuenschwander Lins de; Montenegro, Sílvia Maria Lucena

doi:10.1590/s0034-910.2013047004247

Cited by 29 publications

(24 citation statements)

References 45 publications

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“…Similarly, published data about HCV and schistosomiasis co infection is scanty where only 16 articles could fulfill our criteria. Prevalence rates of HCV infection with wide variations as low as 1% and as high as 50% among patients with schistosomiasis, were reported in different countries [ 24 - 26 ]. Likewise high (40.2%) prevalence of HCV and S. mansoni antibodies were detected among 233 wastewater treatment plants workers [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Schistosomiasis, hepatitis B and hepatitis C co-infection

Gasim

Bella

Adam

2015

Virol J

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BackgroundSchistosomiasis is a significant health problem in more than 70 countries distributed between Africa, Asia and South America, with an infection rate of one in 30 individuals. Data on Schistosomiasis, Hepatitis B virus (HBV) and Hepatitis C virus (HCV) co-infection are scarce; however, there is a high prevalence in countries where schistosomiasis is endemic.MethodsA systematic search was performed on published data from 1980–2014. Published papers in the databases Google, Medline, PubMed, and MiPc library were searched using the keywords epidemiology, pathogenesis and outcomes of HBV, HCV and schistosomiasis and data were extracted from the relevant studies.ResultsThe prevalence of HBV/schistosomiasis co-infection in countries where schistosomiasis is endemic was high, ranging between 9.6 to approximately 64% in Egypt, and a maximum of 15.8% among hospitalized patients in Brazil. Concurrent infection between HBV and schistosomiasis is often associated with countries where schistosomiasis is endemic and may lead to chronic liver inflammation. Similarly, HCV infection rates in schistosomiasis populations range from 1% in Ethiopia reaching up to 50% in Egypt.ConclusionThere is controversy regarding the effects of HBV and HCV on schistosomiasis and vice versa. Vaccination might be a solution to the era of schistosomiasis and co-infection with HBV and HCV.

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Section: Introductionmentioning

confidence: 99%

Schistosomiasis, hepatitis B and hepatitis C co-infection

Gasim

Bella

Adam

2015

Virol J

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“…The hepatitis C virus (HCV) co‐infection in S. mansoni ‐infected individuals is a significant problem, particularly in some countries such as Egypt and Brazil (Van‐Lume et al, 2013). In order to understand the factors involved in the association between schistosomiasis and HCV infection, El‐Moamly et al (2013) evaluated the variant CCR5Δ32 in S. mansoni ‐infected and in S. mansoni /HCV co‐infected Egyptian patients.…”

Section: Ccr5 and Ccr5δ32 In Parasitic Infectionsmentioning

confidence: 99%

CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box

Ellwanger

Kaminski

Rodrigues

et al. 2020

Int J Immunogenetics

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The CCR5 molecule was reported in 1996 as the main HIV‐1 co‐receptor. In that same year, the CCR5Δ32 genetic variant was described as a strong protective factor against HIV‐1 infection. These findings led to extensive research regarding the CCR5, culminating in critical scientific advances, such as the development of CCR5 inhibitors for the treatment of HIV infection. Recently, the research landscape surrounding CCR5 has begun to change. Different research groups have realized that, since CCR5 has such important effects in the chemokine system, it could also affect other different physiological systems. Therefore, the effect of reduced CCR5 expression due to the presence of the CCR5Δ32 variant began to be further studied. Several studies have investigated the role of CCR5 and the impacts of CCR5Δ32 on autoimmune and inflammatory diseases, various types of cancer, and viral diseases. However, the role of CCR5 in diseases caused by bacteria and parasites is still poorly understood. Therefore, the aim of this article is to review the role of CCR5 and the effects of CCR5Δ32 on bacterial (brucellosis, osteomyelitis, pneumonia, tuberculosis and infection by Chlamydia trachomatis) and parasitic infections (toxoplasmosis, leishmaniasis, Chagas disease and schistosomiasis). Basic information about each of these infections was also addressed. The neglected role of CCR5 in fungal disease and emerging studies regarding the action of CCR5 on regulatory T cells are briefly covered in this review. Considering the “renaissance of CCR5 research,” this article is useful for updating researchers who develop studies involving CCR5 and CCR5Δ32 in different infectious diseases.

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“…There were reviews of the relationship with other disorders such as thyroid dysfunction during single and combination therapy of interferon-α,39 outcomes of treatment-naïve HCV patients coinfected with HIV,40 interferon-associated retinopathy during the treatment of chronic HCV,41 and the association between Schistosomiasis mansoni infection and HCV 42. Moreover, there were studies about the determinants of HCV treatment completion and efficacy in drug users,43 the effects of mode of delivery, labor management strategies, and breastfeeding practices on risk reduction for mother-to-infant transmission of HCV,44 the survival advantage of kidney transplantation over dialysis in patients with HCV,45 and the benefit and harms of HCV screening in asymptomatic adults 46…”

Section: Hcvmentioning

confidence: 99%

Overview and recent trends of systematic reviews and meta-analyses in hepatology

Kim

Baik

2014

Clin Mol Hepatol

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A systematic review (SR) is a research methodology that involves a comprehensive search for and analysis of relevant studies on a specific topic. A strict and objective research process is conducted that comprises a systematic and comprehensive literature search in accordance with predetermined inclusion/exclusion criteria, and an assessment of the risk of bias of the selected literature. SRs require a multidisciplinary approach that necessitates cooperation with clinical experts, methodologists, other experts, and statisticians. A meta-analysis (MA) is a statistical method of quantitatively synthesizing data, where possible, from the primary literature selected for the SR. Review articles differ from SRs in that they lack a systematic methodology such as a literature search, selection of studies according to strict criteria, assessment of risk bias, and synthesis of the study results. The importance of evidence-based medicine (EBM) in the decision-making for public policy has recently been increasing thanks to the realization that it should be based on scientific research data. SRs and MAs are essential for EBM strategy and evidence-based clinical practice guidelines. This review addresses the current trends in SRs and MAs in the field of hepatology via a search of recently published articles in the Cochrane Library and Ovid-MEDLINE.

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Association between Schistosomiasis mansoni and hepatitis C: systematic review

Cited by 29 publications

References 45 publications

Schistosomiasis, hepatitis B and hepatitis C co-infection

Schistosomiasis, hepatitis B and hepatitis C co-infection

CCR5 and CCR5Δ32 in bacterial and parasitic infections: Thinking chemokine receptors outside the HIV box

Overview and recent trends of systematic reviews and meta-analyses in hepatology

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