Association between selective IgA deficiency and COVID-19

Naito, Yuji; Takagi, Tomohisa; Yamamoto, Tetsuro; Watanabe, Shaw

doi:10.3164/jcbn.20-102

Cited by 27 publications

(33 citation statements)

References 12 publications

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“…Lastly, PAD patients and SIgAD patients might have a very low or suboptimal response to SARS-CoV-2 immunization, lacking a major tool for systemic and mucosal protection. It has been reported that patients of PAD ( Naito et al., 2020 ), have an increased length of SARS-CoV-2 positivity, before their swab becomes PCR negative, even if this finding may be observed even in the general population of non-immunocompromised subjects. This finding is in fact in agreement with the observation that immunocompromised patients and severe-to-critical patients may remain a source of infection to their environment ( Choi et al., 2020 ).…”

Section: Primary Antibody Deficiencies Selective Iga Deficiency and mentioning

confidence: 99%

“…It has been shown that a low frequency of SIgAD has been shown to positively correlate with the lower prevalence of COVID-19 in Japan in comparison to other countries where SIgAD reaches a frequency of 1:600 inhabitants ( Naito et al., 2020 ). However, differently from what suggested in the paper, there is not the strategy to promote the production of serum and sIgA in patients with Selective IgA deficiency, nor it is possible to use other therapeutic strategies, such as the use of convalescent plasma, in that, in patients who lack IgA there is a contraindication for the use of plasma for possible adverse reactions.…”

Section: Primary Antibody Deficiencies Selective Iga Deficiency and mentioning

confidence: 99%

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IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection

Quinti

Mortari

Salinas

et al. 2021

Front. Cell. Infect. Microbiol.

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A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It protects the epithelial barriers from pathogens and modulates excessive immune responses in inflammatory diseases. An early SARS-CoV-2 specific humoral response is dominated by IgA antibodies responses greatly contributing to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA (sIgA) might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency. Differently from other primary antibody deficiency entities, Selective IgA Deficiency occurs in the vast majority of patients as an asymptomatic condition, and it is often an unrecognized, Studies are needed to clarify the open questions raised by possible consequences of a lack of an IgA response to SARS-CoV-2.

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Section: Primary Antibody Deficiencies Selective Iga Deficiency and mentioning

confidence: 99%

Section: Primary Antibody Deficiencies Selective Iga Deficiency and mentioning

confidence: 99%

IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection

Quinti

Mortari

Salinas

et al. 2021

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

show abstract

“…(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26) In regard with a condition for immune deficiency, selective IgA deficiency can be associated with COVID-19 the severity of COVID-19 symptoms. (27) In addition to underlying disease of the host, nutritional states of host are also associated with the severity of COVID-19 symptoms. (28,29) Malnutrition and hypoproteinemia were reported to be associated with the severity of COVID-19 symptoms.…”

Section: Discussionmentioning

confidence: 99%

Status of online diet management program users in Japan during the 2020 Coronavirus disease 2019 pandemic

Hamaguchi

Nojiri

Okamura

et al. 2021

J. Clin. Biochem. Nutr.

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The spread of coronavirus disease 2019 (COVID-19) has led to drastic changes in people's lifestyles, including teleworking and restrictions on socializing. In the context of observing social distancing for preventing infection, the need to maintain fitness and health has attracted particular attention. We aimed to determine the relationship between the increase in the number of active users of online diet management applications and COVID-19 infection rates in Japan. A total of 1.5 million rows of log data was analyzed. The active number of users of online diet management applications increased with increase in the number of COVID-19 infections. The active user number in Kanagawa Prefecture, where the first cases of COVID-19 were reported in Japan, was particularly high. Moreover, there was a significant increase in the user number in prefectures under a state of emergency when compared to that in prefectures not under a state of emergency. The social anxiety caused by COVID-19 is expected to increase the demand for online health management applications further. The use of such programs can aid in achieving social distancing while enabling users to maintain healthy lifestyles.

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“…3 Moreover, Naito et al observed that the frequency of selective IgAD has a strong positive correlation with the prevalence of COVID-19 per population. 4 Our discussion focuses on kidney diseases, especially glomerular diseases, associated with IgAD.…”

Section: Discussionmentioning

confidence: 99%

IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report

Pezzutto¹,

Sirolli²,

Liberato³

et al. 2021

IMCRJ

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Background Immunoglobulin A deficiency (IgAD) is the most common form of primary immunodeficiency in western countries. It can be associated with the development of autoimmune diseases both in adults and in children even though the exact pathophysiology is not fully defined. Case Presentation We report here a case of a young patient who developed nephrotic syndrome secondary to membranoproliferative glomerulonephritis associated with the incidental finding of IgAD. We began corticosteroid therapy and angiotensin-converting enzyme inhibitor, and we observed partial remission of the nephrotic syndrome after about nine months; nonetheless, in the following follow-up visits, a progressive decline of renal function was found. Conclusion Our case extends the spectrum of hitherto described glomerulonephritides associated with IgAD which were described until now.

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Association between selective IgA deficiency and COVID-19

Cited by 27 publications

References 12 publications

IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection

IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection

Status of online diet management program users in Japan during the 2020 Coronavirus disease 2019 pandemic

IgA Deficiency and Membranoproliferative Glomerulonephritis: A Case Report

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