Association between sensitization to Aureobasidium pullulans (Pullularia sp) and severity of asthma

Niedoszytko, Marek; Chełmińska, Marta; Jassem, Ewa; Czestochowska, E

doi:10.1016/s1081-1206(10)60688-6

Cited by 58 publications

(39 citation statements)

References 14 publications

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“…Many other species of fungi (eg, Aureobasidium and Helminthosporium) have been associated with asthma. Sensitivity to Aureobasidium pullulans was significantly associated with more severe asthma, and sensitization to Helminthosporium was associated with an increased number of asthma exacerbations requiring hospitalization [38].…”

Section: Fungi As Triggers Of Asthmamentioning

confidence: 99%

Importance of mold allergy in asthma

Portnoy

Barnes²,

Kennedy³

2008

Curr Allergy Asthma Rep

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Fungal exposure is hypothesized (controversially) to contribute to asthma development and to trigger symptoms in patients with asthma. The ubiquity of environmental fungal exposure makes a careful review of evidence essential. Evidence that exposure to high concentrations of fungal spores, antigens, or metabolites is associated with asthma development is limited. However, because mechanisms of asthma genesis are poorly understood, so too are the mechanisms of this potential association. This association is not proof of causality. Stronger evidence supports the hypothesis that fungal exposure triggers symptoms in asthmatic individuals. Proposed mechanisms have been tested and correlations between exposure and symptoms demonstrated. Though some correlations remain speculative, controlled studies could test such hypotheses. Because asthma is common and fungal exposure is ubiquitous, it is surprising that asthmatics don't have more symptoms when exposed to fungi. Fortunately, symptoms are dose dependent, creating an opportunity to develop clinically effective interventions. Given the right guidance, even patients with severe asthma can create healthy indoor environments.

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Section: Fungi As Triggers Of Asthmamentioning

confidence: 99%

Importance of mold allergy in asthma

Portnoy

Barnes²,

Kennedy³

2008

Curr Allergy Asthma Rep

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“…Additionally, a strong association between fungal sensitivity, exposure to fungal spores and life-threatening asthmatic episodes was described [28, 36]. Taken together, the molds Alternaria , Aspergillus , Cladosporium, Helminthosporium, Epicoccum, Aureobasidium and Penicillium have frequently been implicated in allergic asthma [27,37,38,39]. …”

Section: Fungal Type I Allergymentioning

confidence: 99%

The Spectrum of Fungal Allergy

Simon-Nobbe¹,

Denk²,

Pöll³

et al. 2007

Int Arch Allergy Immunol

435

425

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Fungi can be found throughout the world. They may live as saprophytes, parasites or symbionts of animals and plants in indoor as well as outdoor environment. For decades, fungi belonging to the ascomycota as well as to the basidiomycota have been known to cause a broad panel of human disorders. In contrast to pollen, fungal spores and/or mycelial cells may not only cause type I allergy, the most prevalent disease caused by molds, but also a large number of other illnesses, including allergic bronchopulmonary mycoses, allergic sinusitis, hypersensitivity pneumonitis and atopic dermatitis; and, again in contrast to pollen-derived allergies, fungal allergies are frequently linked with allergic asthma. Sensitization to molds has been reported in up to 80% of asthmatic patients. Although research on fungal allergies dates back to the 19th century, major improvements in the diagnosis and therapy of mold allergy have been hampered by the fact that fungal extracts are highly variable in their protein composition due to strain variabilities, batch-to-batch variations, and by the fact that extracts may be prepared from spores and/or mycelial cells. Nonetheless, about 150 individual fungal allergens from approximately 80 mold genera have been identified in the last 20 years. First clinical studies with recombinant mold allergens have demonstrated their potency in clinical diagnosis. This review aims to give an overview of the biology of molds and diseases caused by molds in humans, as well as a detailed summary of the latest results on recombinant fungal allergens.

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“…A. pullulans had been reported to cause nosocomial infection, abscess in the spleen, invasive pulmonary infection, fungemia, peritonitis (among patients on peritoneal dialysis), pneumonia, meningitis, corneal ulcer, catheter-related septicemia, scleral infection, and asthma (Bolignano and Criseo 2003;Clark et al 1995;Hawkes et al 2005;Jones and Christensen 1974;Panda et al 2006;Huang et al 2008;Salkin et al 1986;Niedoszytko et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Emergence of Aureobasidium pullulans as human fungal pathogen and molecular assay for future medical diagnosis

et al. 2011

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Despite the great importance of Aureobasidium pullulans in biotechnology, the fungus had emerged as an opportunistic human pathogen, especially among immunocompromised patients. Clinical detection of this rare human fungal pathogen presently relies on morphology diagnosis which may be misleading. Thus, a sensitive and accurate quantitative molecular assay for A. pullulans remains lacking. In this study, we presented the microscopy observations of A. pullulans that reveals the phenotypic plasticity of the fungus. A. pullulans-specific primers and molecular beacon probes were designed based on the fungal 18S ribosomal RNA (rRNA) gene. Comparison of two probes with varied quencher chemistry, namely BHQ-1 and Tamra, revealed high amplification efficiency of 104% and 108%, respectively. The optimized quantitative real-time PCR (qPCR) assays could detect and quantify up to 1 pg concentration of A. pullulans DNA. Both assays displayed satisfactory performance parameters at fast thermal cycling mode. The molecular assay has great potential as a molecular diagnosis tool for early detection of fungal infection caused by A. pullulans, which merits future study in clinical diagnosis.

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Association between sensitization to Aureobasidium pullulans (Pullularia sp) and severity of asthma

Cited by 58 publications

References 14 publications

Importance of mold allergy in asthma

Importance of mold allergy in asthma

The Spectrum of Fungal Allergy

Emergence of Aureobasidium pullulans as human fungal pathogen and molecular assay for future medical diagnosis

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