Association between sensory nerve action potential and lumbar dorsal root ganglion area

Beom, Jaewon; Kim, Sujin; Suh, Hoon Chang; Kim, Don Kyu; Kang, Si Hyun; Lee, Shi-Uk; Lee, Sang Yoon

doi:10.1016/j.jocn.2018.11.019

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…We measured the L4 DRG in rats and L6 DRG in marmosets since these were the largest of those innervated by the sciatic nerve. We evaluated the cross-sectional area of the entire DRG (Beom et al, 2019 ) for each section of the corresponding DRG.…”

Section: Methodsmentioning

confidence: 99%

Distribution of Large and Small Dorsal Root Ganglion Neurons in Common Marmosets

Kudo

Wupuer

Kubota

et al. 2021

Front. Syst. Neurosci.

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The aim of this study was to elucidate the size and distribution of dorsal root ganglion (DRG) neurons in non-human primates and to compare them with those of rodent DRG neurons. By measuring the size of NeuN-, NF200-, and peripherin-positive DRG neurons in the lumbar spinal cord of rats and marmosets, we found that the cell size distribution pattern was comparable in both species, although DRG neurons in marmosets were larger than those of rodents. This is the first demonstration that DRG neurons in marmosets have a bimodal size distribution, which has been well established in rodents and humans.

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Section: Methodsmentioning

confidence: 99%

Distribution of Large and Small Dorsal Root Ganglion Neurons in Common Marmosets

Kudo

Wupuer

Kubota

et al. 2021

Front. Syst. Neurosci.

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Human Dorsal Root Ganglia

Haberberger

Barry

Dominguez

et al. 2019

Front. Cell. Neurosci.

183

177

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Sensory neurons with cell bodies situated in dorsal root ganglia convey information from external or internal sites of the body such as actual or potential harm, temperature or muscle length to the central nervous system. In recent years, large investigative efforts have worked toward an understanding of different types of DRG neurons at transcriptional, translational, and functional levels. These studies most commonly rely on data obtained from laboratory animals. Human DRG, however, have received far less investigative focus over the last 30 years. Nevertheless, knowledge about human sensory neurons is critical for a translational research approach and future therapeutic development. This review aims to summarize both historical and emerging information about the size and location of human DRG, and highlight advances in the understanding of the neurochemical characteristics of human DRG neurons, in particular nociceptive neurons.

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Association between sensory nerve action potential and lumbar dorsal root ganglion area

Cited by 2 publications

References 16 publications

Distribution of Large and Small Dorsal Root Ganglion Neurons in Common Marmosets

Distribution of Large and Small Dorsal Root Ganglion Neurons in Common Marmosets

Human Dorsal Root Ganglia

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