Association between serotonin Cumulative Genetic Score and the Behavioral Approach System (BAS): Moderation by early life environment

Pearson, Rahel; McGeary, John E.; Beevers, Christopher G.

doi:10.1016/j.paid.2014.06.041

Cited by 53 publications

(13 citation statements)

References 37 publications

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“…In terms of the DA-CGS, similar to the behavioral results, there was a significant interaction between task condition and DA-CGS on NoGo-P3, supporting that P3 amplitude is partly DA modulated (Gallinat et al, 2003;Pogarell et al, 2011).…”

Section: Erps and The Da-cgssupporting

confidence: 79%

Cumulative Dopamine Genetic Score predicts behavioral and electrophysiological correlates of response inhibition via interactions with task demand

Enge

Sach

Reif

et al. 2019

Cogn Affect Behav Neurosci

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Functional genetic polymorphisms in the brain dopamine (DA) system have been suggested to underlie individual differences in response inhibition, namely the suppression of a prepotent or inappropriate action. However, findings on associations between single DA polymorphisms and inhibitory control often are mixed, partly due to their small effect sizes. In the present study, a cumulative genetic score (CGS) was used: alleles previously associated with both impulsive behavior and lower baseline DA level, precisely the DRD4 Exon III 7-repeat, DAT1 VNTR 10-repeat and the COMT 158val allele, each added a point to the DA-CGS. Participants (N = 128) completed a Go/No-Go task varying in difficulty and EEG recordings were made with focus on the NoGo-P3, an ERP that reflects inhibitory response processes. We found a higher DA-CGS (lower basal/tonic DA level) to be associated with better performance (lower %FA and more adaptive responding) in the very demanding/rapid than in the less demanding/rapid condition, whereas the reverse pattern was true for individuals with a lower DA-CGS. A similar interaction pattern of DA-CGS and task condition was found for NoGo-P3 amplitude. In line with assumptions of distinct optimum DA levels for different cognitive demands, a DA-CGS-dependent variation of tonic DA levels could have modulated the balance between cognitive stability and flexibility, thereby affecting the optimal DA level required for the specific task condition. Moreover, a task demand-dependent phasic DA release might have added to the DA-CGS-related basal/tonic DA levels, thereby additionally affecting the balance between flexibility and stability, in turn influencing performance and NoGo-P3.

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Section: Erps and The Da-cgssupporting

confidence: 79%

Cumulative Dopamine Genetic Score predicts behavioral and electrophysiological correlates of response inhibition via interactions with task demand

Enge

Sach

Reif

et al. 2019

Cogn Affect Behav Neurosci

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“…The polygenic risk scoring approach generally relies upon well-powered GWAS results (though investigations have been conducted in an unweighted fashion using candidate genetic loci (Pearson et al, 2014)) that are relevant to the neural phenotypes under study such as those provided by mega analyses of categorical disorder risk conducted by the Psychiatric Genomics Consortium (PGC; http://www.med.unc.edu/pgc/downloads) (Smoller et al, 2013). A benefit of this approach is that it likely better captures the polygenic nature of psychopathology.…”

Section: Small Effects -Increasing Sample Size and Polygenic Analysesmentioning

confidence: 99%

Genetic Moderation of Stress Effects on Corticolimbic Circuitry

Bogdan

Pagliaccio

Baranger

et al. 2015

Neuropsychopharmacol

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Stress exposure is associated with individual differences in corticolimbic structure and function that often mirror patterns observed in psychopathology. Gene x environment interaction research suggests that genetic variation moderates the impact of stress on risk for psychopathology. On the basis of these findings, imaging genetics, which attempts to link variability in DNA sequence and structure to neural phenotypes, has begun to incorporate measures of the environment. This research paradigm, known as imaging gene x environment interaction (iGxE), is beginning to contribute to our understanding of the neural mechanisms through which genetic variation and stress increase psychopathology risk. Although awaiting replication, evidence suggests that genetic variation within the canonical neuroendocrine stress hormone system, the hypothalamic-pituitary-adrenal axis, contributes to variability in stress-related corticolimbic structure and function, which, in turn, confers risk for psychopathology. For iGxE research to reach its full potential it will have to address many challenges, of which we discuss: (i) small effects, (ii) measuring the environment and neural phenotypes, (iii) the absence of detailed mechanisms, and (iv) incorporating development. By actively addressing these challenges, iGxE research is poised to help identify the neural mechanisms underlying genetic and environmental associations with psychopathology.

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“…These neurons also change their tonic firing rates across trials of reward and punishment, suggestive of signalling on multiple timescales (Cohen et al, 2015). Of the genetic variants shaping the individual differences in the serotonergic system, the serotonin transporter promoter polymorphism has been associated with reward responses in environmentally sensitive manner (Richards et al, 2016), and the composite of risk alleles of three serotonin-related genes was associated with BAS scores (Pearson et al, 2014). Levels of serotonin in the central nervous system (CNS) depend on the activity of tryptophan hydroxylase 2, the rate-limiting enzyme of the synthesis of serotonin.…”

Section: Introductionmentioning

confidence: 99%

Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, andTPH2-703G/T (rs4570625) genotype

Pulver

Kiive

Harro

2020

Acta Neuropsychiatr.

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Objective: Reward sensitivity is an increasingly used construct in psychiatry, yet its possible inner structure and relationship with other affective variables are not well known. Methods: A reward sensitivity measurement scale was constructed on the basis of large item pool collected from birth cohort representative samples (the Estonian Children Personality Behaviour and Health Study; original n = 1238). Affective Neuroscience Personality Scale (ANPS) and the Adult Attention deficit hyperactivity disorder (ADHD) Self-Report Scale (ASRS) were administered in young adulthood. A variant (rs4570625) of the gene encoding tryptophan hydroxylase 2 (TPH2) that is responsible for the synthesis of central serotonin was genotyped. Results: Reward sensitivity consisted of two orthogonal components, operationally defined as Openness to Rewards and Insatiability by Reward, that respectively characterise the striving towards multiple rewards and the strong pursuit and fixation to a particular reward. While SEEKING and PLAY (and to lower extent CARE) of the ANPS co-varied with Openness to Rewards, FEAR, SADNESS, and ANGER were related to Insatiability by Reward. The total score of ASRS was moderately correlated with Insatiability by Reward, while the association with Openness to Rewards was negligible. However, ASRS Inattention had some negative relationship with the Social Experience facet of Openness to Rewards. The T/T homozygotes for the TPH2 promoter polymorphism had lower Insatiability by Reward but not Openness to Rewards. Conclusions: Behaviours sensitive to rewards are separable to the components of variability and fixation, and these components are differentially related to affective aspects of personality, attention, and hyperactivity as well as to TPH2 genotype.

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Association between serotonin Cumulative Genetic Score and the Behavioral Approach System (BAS): Moderation by early life environment

Cited by 53 publications

References 37 publications

Cumulative Dopamine Genetic Score predicts behavioral and electrophysiological correlates of response inhibition via interactions with task demand

Cumulative Dopamine Genetic Score predicts behavioral and electrophysiological correlates of response inhibition via interactions with task demand

Genetic Moderation of Stress Effects on Corticolimbic Circuitry

Reward sensitivity, affective neuroscience personality, symptoms of attention-deficit/hyperactivity disorder, andTPH2-703G/T (rs4570625) genotype

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