Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women

Jukic, Anne Marie Z.; Steiner, Anne Z.; Baird, Donna D.

doi:10.1097/gme.0000000000000312

Cited by 40 publications

(36 citation statements)

References 34 publications

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“…However, for dichotomous outcomes, there was a tendency for insufficient 25OH-D (<30 ng/mL) to be associated with low AMH (<0.7 ng/mL) (odds ratio (95% CI): 1.8 (0.9-4)). An earlier study by the same group of 527 premenopausal women also suggested an association between the vitamin D level and FSH [60]. They showed an inverse association between 25OH-D and urinary FSH.…”

Section: Observational Studiesmentioning

confidence: 77%

“…The median 25OH-D level was 12 ng/mL, with approximately 75% of participants below the recommended level of 20 ng/mL. For an increase of 10 ng/mL in 25OH-D, urinary FSH decreased by 14% (95% confidence interval: −23%-−5%), p = 0.003 [60]. A study of Korean women of similar reproductive ages by Kim et al, however, did not find a correlation between serum vitamin D and AMH levels [45].…”

Section: Observational Studiesmentioning

confidence: 94%

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The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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Accumulating evidence from animal and human studies indicates a role for vitamin D in female reproductive physiology, and numerous clinical studies have suggested its potential benefit for various aspects of human reproduction. Anti-Müllerian hormone (AMH) is an ovarian biomarker that plays an important role in folliculogenesis. It is the most sensitive ovarian reserve marker and is widely used clinically in reproductive medicine. While initial studies have suggested that vitamin D may be associated with ovarian reserve markers, including AMH, evidence has been conflicting. Currently, there is considerable debate in the field whether vitamin D has the capacity to influence ovarian reserve, as indicated by the AMH level. The current systematic review aims to evaluate and summarize the available evidence regarding the relationship between vitamin D and AMH. In total, 18 observational studies and 6 interventional studies were included in this systematic review. Cross-sectional studies have reported largely discrepant findings regarding an association between serum vitamin D and AMH levels, which are likely due to the heterogeneity in study populations, as well as the apparently complex relationship that may exist between vitamin D and AMH. However, meta-analysis of interventional studies performed herein that examined the effects of vitamin D supplementation on serum AMH levels indicates a cause-effect relationship between vitamin D and AMH, the direction of which appears to depend on a woman’s ovulatory status. Serum AMH was significantly decreased following vitamin D supplementation in polycystic ovarian syndrome (PCOS) women (standardized mean difference (SMD) −0.53, 95% CI −0.91 to −0.15, p < 0.007), while it was significantly increased following vitamin D supplementation in ovulatory women without PCOS (SMD 0.49, 95% CI 0.17 to 0.80, p = 0.003). In conclusion, the results of this systematic review demonstrate that the relationship between vitamin D and AMH is a complex one, and large, randomized trials of vitamin D supplementation focusing on different vitamin D status ranges are necessary to gain more insight into the nature of this relationship and the potential benefit of vitamin D to female reproduction in general.

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Section: Observational Studiesmentioning

confidence: 77%

Section: Observational Studiesmentioning

confidence: 94%

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

et al. 2020

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“…Laboratory evidence suggests that the ovary is a target organ for 1,25-dihydroxyvitamin D 3 , the active metabolite of vitamin D 3 , and that vitamin D receptors are expressed in reproductive tissues including the ovary (21,22). Recently, one group observed that plasma 25-hydroxyvitamin D [25(OH)D] 9 concentrations were positively associated with ovarian reserve, providing further evidence of a protective role of vitamin D on ovarian aging (23).…”

Section: Introductionmentioning

confidence: 94%

Vitamin D and calcium intake and risk of early menopause ,

Purdue-Smithe

Whitcomb

Szegda

et al. 2017

The American Journal of Clinical Nutrition

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Background: Early menopause, defined as the cessation of ovarian function before the age of 45 y, affects w10% of women and is associated with higher risk of cardiovascular disease, osteoporosis, and other conditions. Few modifiable risk factors for early menopause have been identified, but emerging data suggest that high vitamin D intake may reduce risk. Objective: We evaluated how intakes of vitamin D and calcium are associated with the incidence of early menopause in the prospective Nurses' Health Study II (NHS2). Design: Intakes of vitamin D and calcium from foods and supplements were measured every 4 y with the use of a food-frequency questionnaire. Cases of incident early menopause were identified from all participants who were premenopausal at baseline in 1991; over 1.13 million person-years, 2041 women reported having natural menopause before the age of 45 y. We used Cox proportional hazards regression to evaluate relations between intakes of vitamin D and calcium and incident early menopause while accounting for potential confounding factors. Results: After adjustment for age, smoking, and other factors, women with the highest intake of dietary vitamin D (quintile median: 528 IU/d) had a significant 17% lower risk of early menopause than women with the lowest intake [quintile median: 148 IU/d; HR: 0.83 (95% CI: 0.72, 0.95); P-trend = 0.03]. Dietary calcium intake in the highest quintile (median: 1246 mg/d) compared with the lowest (median: 556 mg/d) was associated with a borderline significantly lower risk of early menopause (HR: 0.87; 95% CI: 0.76, 1.00; P-trend = 0.03). Associations were stronger for vitamin D and calcium from dairy sources than from nondairy dietary sources, whereas high supplement use was not associated with lower risk. Conclusions: Findings suggest that high intakes of dietary vitamin D and calcium may be modestly associated with a lower risk of early menopause. Further studies evaluating 25-hydroxyvitamin D concentrations, other dairy constituents, and early menopause are warranted.

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“…Various studies have confirmed that lower serum 25(OH)D levels were associated with irregular menstrual cycles [ 87 ]. Vitamin D may also influence the ovarian reserve and is inversely related to FSH level, as was demonstrated by Jukic et al [ 88 ].…”

Section: Discussionmentioning

confidence: 88%

Vitamin D and Uterine Fibroids—Review of the Literature and Novel Concepts

Ciebiera

Włodarczyk

Ciebiera

et al. 2018

IJMS

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This article provides a detailed review of current knowledge on the role of vitamin D and its receptor in the biology and management of uterine fibroids (UFs). Authors present ideas for future steps in this area. A literature search was conducted in PubMed using the following key words: “uterine fibroid” and “vitamin D”. The results of the available studies, published in English from January 2002 up to April 2018, have been discussed. Vitamin D is a group of steroid compounds with a powerful impact on many parts of the human body. This vitamin is believed to regulate cell proliferation and differentiation, inhibit angiogenesis, and stimulate apoptosis. Nowadays, hypovitaminosis D is believed to be a major risk factor in the development of UFs. In many studies vitamin D appears to be a powerful factor against UFs, resulting in inhibition of tumor cell division and a significant reduction in its size, however, the exact role of this compound and its receptor in the pathophysiology of UFs is not fully understood. According to available studies, vitamin D and its analogs seem to be promising, effective, and low-cost compounds in the management of UFs and their clinical symptoms, and the anti-tumor activities of vitamin D play an important role in UF biology. The synergy between vitamin D and selected anti-UF drugs is a very interesting issue which requires further research. Further studies about the biological effect of vitamin D on UF biology are essential. Vitamin D preparations (alone or as a co-drugs) could become new tools in the fight with UFs, with the additional beneficial pleiotropic effect.

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Association between serum 25-hydroxyvitamin D and ovarian reserve in premenopausal women

Cited by 40 publications

References 34 publications

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

The Association between Vitamin D and Anti-Müllerian Hormone: A Systematic Review and Meta-Analysis

Vitamin D and calcium intake and risk of early menopause ,

Vitamin D and Uterine Fibroids—Review of the Literature and Novel Concepts

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