Association between Serum 25-Hydroxyvitamin D Levels and TTN

Abstract

Aim: To investigate the association between serum 25-hydroxyvitamin D (25(OH)D₃) levels and transient tachypnea of the newborn (TTN). Methods: Calcium (Ca), phosphorus (P), alkaline phosphatase (ALP), parathormone (PTH) and serum 25(OH)D₃ levels were measured in 51 infants diagnosed with TTN and 59 healthy control infants for comparison. Demographic factors including gestational age, birth weight, gender, delivery mode, parity, vitamin D supplementation during pregnancy and severity of TTN were recorded. Results: The serum levels of 25(OH)D₃ were significantly lower in infants with TTN compared to infants with no respiratory distress (p < 0.01). There was no statistically significant difference in serum Ca, P and ALP levels between the groups while the serum levels of PTH were significantly higher in the study group (p < 0.01). No correlation was found between the serum 25(OH)D₃ levels and severity of TTN. Vitamin D supplementation (400 IU/day) during pregnancy did not affect the serum levels of newborns. Conclusion: Our data suggests that lower 25(OH)D₃ serum levels are associated with an increased risk of TTN and vitamin D may have a role in the pathogenesis of TTN.

Association of serum vitamin D levels and transient tachypnea of newborn: a case control study

“…Similar results were found in the study done by Konca et al in 2014 in which serum vitamin D levels were studied in infants diagnosed as TTN and those without TTN and found that the serum levels of 25(OH)D3 were significantly lower in infants with TTN compared to infants with no respiratory distress (p<0.01). 30 The fetus is dependent on the mother for vitamin D in utero (the 25(OH)D3 crosses the placenta). 31 In our study we found statistically significant role of supplementation of vitamin D in pregnancy on serum vitamin D levels in neonates as these neonates were less deficient in vitamin D as compared to neonates whose mothers were not supplemented.…”

“…15. Similar results were found in the study done by Konca et al in 2014 in which serum vitamin D levels were studied in infants diagnosed as TTN and those without TTN and found that the serum levels of 25(OH)D3 were significantly lower in infants with TTN compared to infants with no respiratory distress (p<0.01). 30 The fetus is dependent on the mother for vitamin D in utero (the 25(OH)D3 crosses the placenta).…”

“…A surge in catecholamines and endogenous steroids increase the expression and activity of ENaC. 12,13 As hypothesized by Konca et al 30 that vitamin D deficiency may decrease the expression of ENaC (as steroid hormone) and surfactant synthesis and develop TTN. Based on these observations we also studied association of vitamin D deficiency in transient tachypnea of newborns.…”

Association of Vitamin D Deficiency with Postnatal Respiratory Distress in Newborns

“…tik anne bebeği ve D vitamini eksikliği yer almaktadır (1)(2)(3) . Vitamin D kalsiyum, fosfor metabolizması üzerine önemli etkilerinin yanında antiinflamatuvar ve antienfektif özellikleri de olan steroid yapıda bir hormondur (4) .…”

Maternal Vitamin D Deficiency May be a Risk Factor for Transient Tachypnea of the Newborn

“…18,19 Literatürde tek bir çalışmada YGT olan bebeklerde 25(OH)D 3 düzeyi sağlıklı kontrollere göre anlamlı olarak düşük bulunmuştur. 20 Bu çalışmada, hem neonatal hem de maternal vitamin D eksikliğinin YGT gelişimine etkisi olup olmadığı irdelenmiştir. Kliniğimizde belirlenen tarih aralığında 1.238 doğum gerçekleşmiş olup, bu doğumların 842'si sezaryen doğum idi.…”