Association between serum arsenic levels and gestational diabetes mellitus: A population-based birth cohort study

Xia, Xin; Liang, Chunmei; Sheng, Jie; Yan, Shuangqin; Huang, Kun; Li, Zhijuan; Pan, Weijun; Tao, Ruiwen; Hao, Jiahu; Zhu, Beibei; Tong, Shilu; Tao, Fangbiao

doi:10.1016/j.envpol.2018.01.016

Cited by 41 publications

(34 citation statements)

References 43 publications

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“…As we described above, contrasting with other studies in which the strongest association between gestational diabetes and arsenic was for the highest exposure category [ 23 , 24 , 25 , 26 ], in our study we did not find a dose–response association. Ettinger et al reported an association between glucose intolerance and the quartile of highest arsenic blood exposure (OR = 2.8; 95% CI = 1.1–6.9) [ 23 ], and Shapiro et al also found an association between gestational diabetes and the quartile of highest exposure to blood arsenic concentration (OR = 3.7; 95% CI = 1.4–9.6) [ 24 ].…”

Section: Discussioncontrasting

confidence: 99%

“…The present study is one of the few that provides evidence with total urine inorganic arsenic concentration as the exposure variable. Indeed, previous studies showing significant associations have used arsenic in meconium (total arsenic) [ 26 ], nail (inorganic arsenic) [ 27 ], water (inorganic arsenic) [ 27 , 28 ], and blood (total arsenic) [ 23 , 24 , 25 ] as the exposure variable. The only study that reported inorganic arsenic in urine as the exposure variable did not find a consistent and significant association [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Ettinger et al reported an association between glucose intolerance and the quartile of highest arsenic blood exposure (OR = 2.8; 95% CI = 1.1–6.9) [ 23 ], and Shapiro et al also found an association between gestational diabetes and the quartile of highest exposure to blood arsenic concentration (OR = 3.7; 95% CI = 1.4–9.6) [ 24 ]. Xia et al, in a recent cohort study, revealed an association between blood arsenic concentration and GDM in the 4th quartile (OR = 1.7; 95% CI 1.23–2.38) [ 25 ]. Besides relating arsenic in blood to glucose intolerance, Ettinger et al studied this outcome’s association with arsenic in hair.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have reported an association between GDM and arsenic levels in maternal blood [ 23 , 24 , 25 ] or meconium [ 26 ]. However, information regarding gestational diabetes and urine inorganic arsenic is scarce.…”

Section: Introductionmentioning

confidence: 99%

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Urinary Inorganic Arsenic Concentration and Gestational Diabetes Mellitus in Pregnant Women from Arica, Chile

Muñoz

Valdés

Muñoz-Quezada

et al. 2018

IJERPH

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Introduction: The association of total arsenic exposure with impaired glucose tolerance and gestational diabetes has been shown; however, evidence regarding urinary inorganic arsenic in pregnant women is still limited. Our aim was to evaluate the association between urinary inorganic arsenic concentration and gestational diabetes among pregnant women living in Arica, Chile. Methods: Cross-sectional study of pregnant women receiving care at primary health centers in urban Arica. The exposure was urinary inorganic arsenic concentration, while gestational diabetes was the outcome. The association was evaluated using multiple logistic regression models adjusted by age, education level, ethnicity, and pre-pregnancy body mass index. Results: 244 pregnant women were surveyed. The median urinary inorganic arsenic was 14.95 μg/L, and the prevalence of gestational diabetes was 8.6%. After adjusting, we did not find a significant association between gestational diabetes and inorganic arsenic exposure tertiles (Odds ratio (OR) 2.98, 95% CI = 0.87–10.18), (OR 1.07, 95% CI = 0.26–4.33). Conclusion: This study did not provide evidence on the relationship between urinary inorganic arsenic concentration and gestational diabetes. Further research is needed to elucidate the factors underlying this association.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary Inorganic Arsenic Concentration and Gestational Diabetes Mellitus in Pregnant Women from Arica, Chile

Muñoz

Valdés

Muñoz-Quezada

et al. 2018

IJERPH

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“…In the Maternal-Infant Research on Environmental Chemicals Study, the risk of GDM was nearly fourfold greater in the highest vs lowest tertile of dimethylarsinic acid levels [53]. Overall, arsenic has been associated with GDM in many [54][55][56][57] but not all studies [58]. In addition to disruptions during gestation, the dynamic changes that happen in the pancreatic islet under the influence of pregnancy hormones suggest that environmental insults that occur during this window may permanently reprogram beta cells and thereby alter their long-term function.…”

Section: Beyond Offspring: Impact Of Gestational Exposures On Mothersmentioning

confidence: 99%

Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors

2019

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Type 2 diabetes prevalence is increasing dramatically across the globe, imposing a tremendous toll on individuals and healthcare systems. Reversing these trends requires comprehensive approaches to address both classical and emerging diabetes risk factors. Recently, environmental toxicants acting as endocrine-disrupting chemicals (EDCs) have emerged as novel metabolic disease risk factors. EDCs implicated in diabetes pathogenesis include various inorganic and organic molecules of both natural and synthetic origin, including arsenic, bisphenol A, phthalates, polychlorinated biphenyls and organochlorine pesticides. Indeed, evidence implicates EDC exposures across the lifespan in metabolic dysfunction; moreover, specific developmental windows exhibit enhanced sensitivity to EDC-induced metabolic disruption, with potential impacts across generations. Importantly, differential exposures to diabetogenic EDCs likely also contribute to racial/ethnic and economic disparities. Despite these emerging links, clinical practice guidelines fail to address this underappreciated diabetes risk factor. Comprehensive approaches to stem the tide of diabetes must include efforts to address its environmental drivers.

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Intrauterine programming of obesity and type 2 diabetes

et al. 2019

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The type 2 diabetes epidemic and one of its predisposing factors, obesity, are major influences on global health and economic burden. It is accepted that genetics and the current environment contribute to this epidemic; however, in the last two decades, both human and animal studies have consolidated considerable evidence supporting the 'developmental programming' of these conditions, specifically by the intrauterine environment. Here, we review the various in utero exposures that are linked to offspring obesity and diabetes in later life, including epidemiological insights gained from natural historical events, such as the Dutch Hunger Winter, the Chinese famine and the more recent Quebec Ice Storm. We also describe the effects of gestational exposure to endocrine disruptors, maternal infection and smoking to the fetus in relation to metabolic programming. Causal evidence from animal studies, motivated by human observations, is also discussed, as well as some of the proposed underlying molecular mechanisms for developmental programming of obesity and type 2 diabetes, including epigenetics (e.g. DNA methylation and histone modifications) and microRNA interactions. Finally, we examine the effects of non-pharmacological interventions, such as improving maternal dietary habits and/or increasing physical activity, on the offspring epigenome and metabolic outcomes.

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Association between serum arsenic levels and gestational diabetes mellitus: A population-based birth cohort study

Cited by 41 publications

References 43 publications

Urinary Inorganic Arsenic Concentration and Gestational Diabetes Mellitus in Pregnant Women from Arica, Chile

Urinary Inorganic Arsenic Concentration and Gestational Diabetes Mellitus in Pregnant Women from Arica, Chile

Environmental neglect: endocrine disruptors as underappreciated but potentially modifiable diabetes risk factors

Intrauterine programming of obesity and type 2 diabetes

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