Association between Serum Chemerin Concentrations and Clinical Indices in Obesity or Metabolic Syndrome: A Meta-Analysis

Abstract

ObjectiveChemerin is a novel adipokine. Previous research has investigated the association between chemerin and clinical indices in patients with obesity or metabolic syndrome (MS), although the results obtained have been inconsistent. We conducted a meta-analysis to investigate the association between chemerin and clinical indicators of diabetes, MS and obesity with obesity or MS subjects.Design and MethodsStudies were identified by searching the PubMed, the Cochrane Library, EMBASE and CNKI, databases beginning with the original report in July 2007 until the end of May 2013. For each variable, summary correlation coefficients were estimated using random-effects or fixed-effect meta-analysis with 95% confidence interval (CI) performed by STATA software.ResultsA total of eight studies with 20 clinical variables (total n = 1787) met the inclusion criteria. The meta-analyse of diabetes markers showed that FSI (rs = 0.26; 95% CI = 0.21–0.31; P = 0.000), 2HPG (rs = 0.06; 95% CI = 0.01–0.12; P = 0.030) and HOMA-IR (rs = 0.178; 95% CI = 0.019–0.337; P = 0.028) were positively correlated with chemerin, however, FPG (rs = 0.03, 95% CI = −0.02 to 0.08, P = 0.240) and HbA1c (rs = −0.05; 95% CI = −0.24–0.15; P = 0.641) were not significantly correlated with chemerin. The meta-analyses of MS and obesity markers indicated that TG, TC, CRP BMI, TBF%, WC, WHR and Leptin were positively correlated with chemerin, nevertheless, SBP, DBP, LDL-C, HDL-C, ALT and r-GT were not significantly correlated, adiponectin was negatively correlated. Sensitivity analysis was performed and the summary results did not change significantly.ConclusionsThe results suggest that chemerin in patients with obesity or MS may be associated with obesity, imbalances in lipid and diabetes metabolism and insulin resistance. Chemerin played an important role in the pathophysiology of obesity and MS.

Circulating Chemerin Is Associated With Carotid Plaque Instability, Whereas Resistin Is Related to Cerebrovascular Symptomatology

“…[13][14][15] In line with others, we found high chemerin levels to correlate with T2DM and low high-density lipoprotein. 13,14 Furthermore, a positive correlation was observed between chemerin and macrophage inflammatory protein 1-α, which is known to be involved in atherogenesis.…”

“…[13][14][15] In line with others, we found high chemerin levels to correlate with T2DM and low high-density lipoprotein. 13,14 Furthermore, a positive correlation was observed between chemerin and macrophage inflammatory protein 1-α, which is known to be involved in atherogenesis. 15 Although chemerin is less studied than other adipokines in atherosclerosis, a positive and independent association was noted between chemerin and coronary artery disease.…”

Chemical Pathology of Chemerin and Its Link to Obesity and Type 2 Diabetes Mellitus: A Review

“…Li et al conducted a meta analysis involving various researchers linking chemerin with metabolic syndrome, obesity and diabetes mellitus and they concluded that chemerin in obesity/metabolic syndrome may be positively correlated with insulin resistance. Chemerin was found to play a role in pathophysiology of obesity and metabolic syndrome [17].…”

“…Further studies have implicated chemerin in exercabating glucose intolerance which later gives rise to diabetes mellitus by enhancing insulin resistance [11]. It was also found that reduction in insulin levels were associated with increasing chemerin levels [17]. Again, Li et al suggested chemerin enhanced an imbalance in lipid metabolism, insulin resistance and altered metabolism of glucose [17].…”

“…It was also found that reduction in insulin levels were associated with increasing chemerin levels [17]. Again, Li et al suggested chemerin enhanced an imbalance in lipid metabolism, insulin resistance and altered metabolism of glucose [17]. Xu et al also said that chemerin, being a chemoattractant, is involved in chronic inflammation of adipose tissues in obese conditions.…”