Association between serum cystatin C, monocytes and other inflammatory markers

Evangelopoulos, Angelos; Bountziouka, Vassiliki; Katsagoni, Christina N.; Bathrellou, Eirini; Vogiatzakis, Evangelos; Bonou, Μaria; Barbetseas, John; Avgerinos, Peter C.; Panagiotakos, Demosthenes B.

doi:10.1111/j.1445-5994.2011.02500.x

Cited by 32 publications

(31 citation statements)

References 38 publications

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“…A plausible link between increased cystatin C concentrations and adverse cardiovascular outcome apart from renal failure could be chronic inflammation such as atherosclerosis. Indeed, high serum cystatin C concentrations have been documented to be associated with high concentrations of hs-CRP and monocytes count in blood (20,21). In fact, the mono- cyte count in blood has been found to be a better cross-sectional marker of plaque presence than hs-CRP, interleukin-6 and WBC (22).…”

Section: Discussionmentioning

confidence: 99%

Inverse Relationship Between Adherenceto the Mediterranean Diet and Serum Cystatin C Levels

Georgousopoulou

Evangelopoulos

Bountziouka

et al. 2017

Cent Eur J Public Health

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SUMMARYObjective: The aim of the present study was to examine serum cystatin C levels in association with the Mediterranean diet in a healthy Greek population.Methods: Cystatin C together with basic clinical chemistry tests was measured in a total of 490 adults (46 ± 16 years, 40% of males), who underwent an annual health check. Demographic, anthropometric and lifestyle characteristics were recorded, while adherence to the Mediterranean diet was evaluated through the MedDietScore (0-55).Results: The mean level of serum cystatin C was 0.84 mg/L, while men had increased serum cystatin C levels compared to women (0.86 mg/L vs. 0.83 mg/L, respectively, 0.017). After adjusting for age, gender, body mass index, smoking status, hypertension, diabetes, hypercholesterolemia, estimated glomerular filtration rate (eGFR), albumin and ferritin levels, each unit increase in MedDietScore led to 0.002 mg/dL drop off in cystatin C serum levels.Conclusions: We have demonstrated an inverse relationship between the MedDietScore and serum cystatin C levels. Our finding that increases in MedDietScore are associated with decreases in serum cystatin C levels could imply that adherence to the Mediterranean diet may reduce the cardiovascular risk, as assessed by cystatin C, a prognostic marker of the cardiometabolic risk. This notion could have a great impact on public health.

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Section: Discussionmentioning

confidence: 99%

Inverse Relationship Between Adherenceto the Mediterranean Diet and Serum Cystatin C Levels

Georgousopoulou

Evangelopoulos

Bountziouka

et al. 2017

Cent Eur J Public Health

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“…In conclusion, there are no epidemiological or randomized studies, based on direct measures of GFR as a predictor of cardiovascular outcome, evaluating whether the association between elevated serum Cys-C concentrations and risk of a worse outcome reflects a more accurate measurement of renal function or an association with non-kidney factors such as inflammation [18][19][20] .…”

Section: Is Cystatin-c Also An Inflammatory Marker?mentioning

confidence: 99%

Clinical Significance of Cystatin C in Acute Coronary Syndromes: Something More Than a Marker of Renal Function?

Mariani¹,

Mariani²,

Servi³

2014

Inflamm Cell Signal

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Serum cystatin C (Cys-C) levels perform better than other markers of renal function as indicator of cardiovascular outcome both in population-based studies and in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). Whether the relation between elevated serum Cys-C levels and risk of a worse cardiovascular prognosis reflects a more precise measurement of renal function or an association with nonrenal factors such as inflammation is a matter still poorly defined. In a prospective, multicenter study our group evaluated the time course of serum Cys-C levels in 222 patients over the first 6 weeks after an episode of NSTE-ACS and a successful percutaneous revascularization. We observed that Cys-C levels slightly but significantly increased from the admission to 6-week samples (7.1 to 7.8 mg/dL, p <0.0001), contrary to high sensitivity C Reactive Protein (hsCRP), N-terminal portion of the proBNP peptide (NT-proBNP), and Interleukin 6 (IL-6) levels which significantly decreased in the same period. Cys-C levels were not different in patients with or without elevated troponin (c-TnT), whereas the other inflammatory and biomechanical markers showed higher values in patients with versus those without increased c-TnT. Cys-C was highly correlated with estimated glomerular filtration rate both in ACS and 6-week samples. In conclusion, our data seem to contradict the hypothesis that inflammation is a determinant of the Cys-C levels because they did not show the typical pattern of an acute-phase reactant and secondly they were independent from myocardial necrosis diagnosed by c-TnT levels. Moreover, our results show that Cys-C remains a reliable marker of renal function also during ACS because is not influenced by myocardial necrosis or by acute left ventricular disfunction, as detected by increased NT-proBNP values.

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“…Consequently several Cystatin C based GFR equations, were derived [40,41] . More recently cystatin C has been recognized to be affected by numerous factors including inflammation [42] body composition, proteinuria, cardiovascular risk factors [43,44] infection, thyroid dysfunction, underlying malignancy, smoking and a number of drugs; including corticosteroids, cotrimoxazole, angiotensin converting enzyme inhibitors, and calcineurin inhibitors. Cystatin C has been reported to increase with severity of chronic liver disease [45] as it correlates with bilirubin, INR and CTP stage, and negatively with serum albumin and peripheral platelet count [46] .…”

Section: Alternatives To Creatinnementioning

confidence: 99%

Difficulties in diagnosing acute kidney injury post liver transplantation using serum creatinine based diagnostic criteria

Agarwal

Davenport

2014

WJH

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Renal function in patients with advanced cirrhosis is an important prognostic factor for survival both prior to and following liver transplantation. The importance of renal function is reflected by the introduction of the model for end stage liver disease (MELD) score, which includes serum creatinine. The MELD score has been shown to predict the short term risk of death for transplant wait listed patients and is currently used by many countries to allocate liver transplants on the basis of severity of underlying illness. Changes in serum creatinine are also used to stage acute kidney injury. However prior to liver transplantation the serum creatinine typically over estimates underlying renal function, particularly when a colorimetric Jaffe based assay is used, and paradoxically then under estimates renal function post liver transplantation, particularly when immunophyllins are started early as part of transplant immunosuppression. As acute kidney injury is defined by changes in serum creatinine, this potentially leads to over estimation of the incidence and severity of acute kidney injury in the immediate post-operative period. Key words: Serum creatinine; Acute kidney injury; Liver transplantationCore tip: Acute kidney injury is defined and severity graded based on changes in serum creatinine. Increasing concentrations of bilirubin interefere with laboratory determination of creatinine and reduce creatinine estimations. Post transplantation serum creatinine increases due to a combination of fall bilirubin and the loading doses of calcineurin inhibitor immunosupressants. This combination leads to an over estimation of the lesser grades of acute kidney injury post liver transplantation.Agarwal B, Davenport A. Difficulties in diagnosing acute kidney injury post liver transplantation using serum creatinine based diagnostic criteria. World J Hepatol 2014; 6(10): 696-703 Available from:

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Association between serum cystatin C, monocytes and other inflammatory markers

Cited by 32 publications

References 38 publications

Inverse Relationship Between Adherenceto the Mediterranean Diet and Serum Cystatin C Levels

Inverse Relationship Between Adherenceto the Mediterranean Diet and Serum Cystatin C Levels

Clinical Significance of Cystatin C in Acute Coronary Syndromes: Something More Than a Marker of Renal Function?

Difficulties in diagnosing acute kidney injury post liver transplantation using serum creatinine based diagnostic criteria

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