Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis

Rey, Imelda; Effendi-Ys, Rustam

doi:10.5455/medarh.2021.75.199-203

Cited by 10 publications

(7 citation statements)

References 43 publications

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“…The study of Rey and Luo Ming shows that IL-6 is related to the severity of liver cirrhosis and to blood ammonia levels in patients with OHE. 22 , 23 However, our study did not get similar results, and we speculate that it may be because our study population (including various etiology) is different from previous reports.…”

Section: Discussioncontrasting

confidence: 92%

Association of preoperative IL-6 levels with overt HE in patients with cirrhosis after TIPS

Liu

et al. 2023

Hepatology Communications

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Background: HE is a common and dangerous complication after TIPS. The relationship between IL-6 levels and overt HE (OHE) after TIPS is rarely reported.We aimed to explore the relationship between the preoperative serum IL-6 levels and OHE risk after TIPS, and to evaluate its value in predicting the OHE risk. Methods: This prospective cohort study included 125 participants with cirrhosis who received TIPS. Logistics regression analyses were performed to explore the relationship between IL-6 and OHE risk, and the receiver operating characteristic analysis was used to compare the predictive power of IL-6 and other indexes. Results: Among 125 participants, 44 (35.2%) participants developed OHE after TIPS. Logistics regression showed preoperative IL-6 was associated with a higher OHE risk after TIPS in different models (all p < 0.05). Participants with IL-6 > 10.5 pg/mL had a higher cumulative incidence of OHE after TIPS than those with IL-6 ≤ 10.5 pg/mL (log-rank = 0.0124). The predictive power of IL-6 (AUC = 0.83) for the OHE risk after TIPS was higher than that of other indexes. Age (RR = 1.069, p = 0.002) and IL-6 (RR = 1.154, p < 0.001) were independent risk factors for OHE after TIPS. IL-6 was also a risk factor for the occurrence of coma in patients with OHE (RR = 1.051, p = 0.019). Conclusion: Preoperative serum IL-6 levels are closely related to the occurrence of OHE in patients with cirrhosis after TIPS. Patients with cirrhosis with high serum IL-6 levels following TIPS were at a higher risk of developing severe HE.

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Section: Discussioncontrasting

confidence: 92%

Association of preoperative IL-6 levels with overt HE in patients with cirrhosis after TIPS

Liu

et al. 2023

Hepatology Communications

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“…Interleukin-6 (IL-6) is an important cytokine regulating immune and inflammatory responses in the liver and is known to induce collagen synthesis [3, 4]. It also seems to correlate with the severity of LC [6]. In this study, we found that preoperatively determined baseline IL-6 levels might be a promising preoperative biomarker for LF.…”

Section: Discussionmentioning

confidence: 79%

“…Elevated IL-6 serum levels have been reported in patients with hepatitis B infection, acute hepatitis, and alcoholic LC [4]. Impaired hepatic removal of IL-6 is also reported in patients with LC [5] and appears to correlate with the severity of LC [6].…”

Section: Introductionmentioning

confidence: 99%

Baseline Interleukin-6 as a Preoperative Biomarker for Liver Fibrosis

Koch,

Koliogiannis,

Drefs

et al. 2023

Visc Med

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Introduction: Liver (hepatic) fibrosis (LF) is characterized by impaired function and regenerative capacity of the liver and can lead to significantly increased morbidity and mortality in the context of surgical liver resection (LR). For this reason, it is crucial to identify the extent of LF preoperatively. Interleukin-6 (IL-6) is known to play a key role in the pathogenesis of LF, but its exact value as a preoperative marker is unknown. This study aimed to investigate the correlation between preoperatively determined IL-6 and the presence of LF. Methods: In this prospective study, IL-6 was determined in 134 consecutive patients undergoing LR. Patients with liver cirrhosis (LC) and patients with clinical or laboratory signs of inflammation were excluded. LF was graded by a blinded pathologist with regard to the degree of LF according to the Desmet classification (0–4). Baseline IL-6 and degree of LF were correlated. Results: A total of 134 patients were prospectively included prior to LR. For 104 patients, LF was graded and inflammatory parameters were available. Thirty-five of these patients showed LC (Desmet 4), and another 33 patients showed preoperatively elevated inflammatory markers. Two of the remaining patients were liver transplant patients. These patients were excluded from the final analysis. According to Desmet, the remaining 34 patients had LF grade 0 or 1 (none or minimal LF) in 26 cases and LF grade 2 or 3 (moderate-to-severe LF) in 8 cases. Correlation of LF with preoperatively determined IL-6 yielded significantly higher IL-6 levels in the group of patients with moderate-to-severe LF (Desmet 2 or 3) compared to the group with none or minimal LF (Desmet 0 or 1; p = 0.0495). Conclusion: In the context of LR, our results showed a correlation of preoperatively determined IL-6 with the extent of LF present. Higher serum baseline IL-6 concentrations were associated with a higher degree of LF, whereas no other blood parameter or score was that predictive for LF. Our results suggest that baseline IL-6 might serve as a valuable parameter to assess LF prior to LR. More patients need to be analyzed to further evaluate and confirm the predictive accuracy of IL-6 for LF.

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“…IL-17 activates the STAT3 signaling pathway in HSC, producing type 1 collagen and promoting the development of liver fibrosis; the absence of IL-23 or the use of IL-17E (also known as IL-25) attenuates hepatic fibrosis; 24 and the level of IL-17 is positively correlated with the degree of liver damage in patients with hepatitis A. In hepatitis B (HBV) and hepatitis C virus (HCV) infections, IL-23 promoted chronic inflammation, IL-23 may enhance HCV infection mediated by dendritic cells and macrophages, 25 and IL-23 concentrations were significantly elevated in patients with cirrhosis caused by HBV and HCV infections, 26 there is a close correlation between IL-17 and IL-23 expression levels, and IL-23 may play a role in the pathogenesis of hepatitis B cirrhosis by inducing the production of IL-17 and the latter. In the present study, IL-17 and IL-23 concentrations increased significantly with increasing hepatic inflammation in patients and reached the highest concentrations in cirrhotic patients, similar to previous studies.…”

Section: Discussionmentioning

confidence: 99%

Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis

Yang,

Liao,

Liang

et al. 2024

JIR

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Objective This research aimed to explore the involvement of interleukins (IL) - IL-6, IL-17, IL-21, and IL-23 - in the evolution and diagnosis of non-alcoholic liver fibrosis and cirrhosis. Methods The study subjects were selected from the patients who visited the Department of Hepatology of X Hospital in Y City from August 2021 to April 2023. Peripheral blood samples were collected. All participants were divided into liver fibrosis, cirrhosis, hepatitis, and healthy subjects four groups. IL-21, IL-17, IL23, IL-6 were detected by double antibody sandwich. Results The results showed that there was a significant difference in the levels of IL-17, IL-21, and IL-23 among the 4 groups (P<0.0001). ROC curve analysis showed that the AUC values of IL-17, IL-21 and liver fiber 4 items were >0.70, suggesting that the diagnostic efficacy of IL-17, IL-21 was similar to that of liver fiber 4 items. Spearman correlation analysis showed that IL-17 had a positive correlation with collagen type III N-peptide, type IV collagen, and Laminin (P < 0.05), and no correlation with Hyaluronic acid (P > 0.05). Conclusion IL-17, IL-21, and IL-23 play a pivotal role in the inflammatory pathways associated with liver injuries, establishing themselves as potent auxiliary diagnostic markers in identifying liver fibrosis and cirrhosis.

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Association Between Serum IL-6, IL-10, IL-12, and IL-23 Levels and Severity of Liver Cirrhosis

Cited by 10 publications

References 43 publications

Association of preoperative IL-6 levels with overt HE in patients with cirrhosis after TIPS

Association of preoperative IL-6 levels with overt HE in patients with cirrhosis after TIPS

Baseline Interleukin-6 as a Preoperative Biomarker for Liver Fibrosis

Correlation Analysis of IL-17, IL-21, IL-23 with Non-Alcoholic Liver Fibrosis and Cirrhosis

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