Association between serum levels of hepcidin and ferritin in patients with thalassemia major and intermedia, the role of iron chelator

Hossaini, Seyed Kamal Eshagh; Haeri, Mohammad Reza

doi:10.1007/s12308-019-00363-x

Cited by 7 publications

(1 citation statement)

References 17 publications

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“…1 ). In addition to treatment of the inflammatory state ( Mehta et al, 2020 ), we envisage the application of approved iron chelators, ferroptosis inhibitors, hepcidin modulators and erythropoietin in management of COVID-19 ( Eshagh Hossaini et al, 2019 , Monti et al, 2002 ). Iron chelators would be a more adapted option with minimal side effects ( Edeas et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Mitochondria and microbiota dysfunction in COVID-19 pathogenesis

et al. 2020

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Highlights Mitochondria are the hub of cellular oxidative homeostasis. Mitochondria are the major source of reactive oxygen species (ROS). Extracellular mitochondria are found in blood, in circulating platelets and vesicles. COVID-19 pathogenesis is aggravated by the hyper- inflammatory state. Inflammation activates events leading to microbiota & mitochondrial oxidative damage. Mitochondrial damage contributes to coagulopathy, ferroptosis & microbial dysbiosis. Blood & platelet mitochondria dysfunction may accelerate systemic coagulopathy events. Targeting mitochondria dysfunction may provide useful therapeutic strategies against COVID-19 pathogenesis.

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