Association between serum periostin concentrations and outcome after acute spontaneous intracerebral hemorrhage

Ji, Wen-Jian; Chou, Xiao-Min; Wu, Gang-Qun; Shen, Yang-Fang; Yang, Xiaofei; Wang, Zhifeng; Lan, Luo-Xin; Shi, Xugang

doi:10.1016/j.cca.2017.09.002

Cited by 14 publications

(12 citation statements)

References 27 publications

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“…The NIHSS score at discharge was a risk factor for unfavorable outcome in our study (OR 3.152, p = 0.002), which is consistent with the study of Ji et al 40 . Moreover, in a study by Satopaa et al, comparing 19 published prognostic scores, the authors concluded that NIHSS was the best and should be performed to quantify risk factors for in-hospital death 41 .…”

Section: Discussionsupporting

confidence: 93%

Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage

Zhao

Fang

et al. 2019

Cell Transplant

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To determine whether non-alcoholic fatty liver disease (NAFLD) and intracerebral hemorrhage (ICH) are connected, and assess the role played by NAFLD in ICH development. A retrospective study evaluated inpatients treated at the First Affiliated Hospital of Zhejiang University. We divided the patients into Group A (ICH with NAFLD) and Group B (ICH alone). Moreover, univariate and multivariate logistic regression analyses were performed to identify the risk factors for unfavorable outcomes. A total of 128 patients were included: 34 ICH with NAFLD (group A) and 94 ICH (group B). Sixteen patients exhibited an unfavorable outcome. There was no significant difference among the two groups on the underlying diseases hypertension and heart disease. Group A had more diabetes mellitus cases (35.29% vs 12.76%, p = 0.004). Levels of alanine aminotransferase and triglyceride were higher in group A than in group B (all p < 0.05), while differences in other blood biochemistry tests were statistically insignificant (all p > 0.05). There was a similarity in bleeding sites except for brainstem hemorrhage, which was higher in group B patients ( p = 0.036). Multivariate logistic regression analysis revealed that low-density lipoprotein (OR, 0.278; 95% CI (0.107–0.702), p = 0.008) was a protective factor for ICH patients with NAFLD. The National Institute of Health Stroke Scale (NIHSS) score at discharge (OR, 3.152; 95% CI (1.532–6.486), p = 0.002) was independent of risk factors for unfavorable outcomes. Serum levels of LDL was a protective factor. NAFLD did not increase the unfavorable outcome of ICH patients in our study.

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Section: Discussionsupporting

confidence: 93%

Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage

Zhao

Fang

et al. 2019

Cell Transplant

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“…Previous studies found that increased periostin levels were associated with clinical severity and poor outcome in patients with traumatic brain injury 17 , aneurysmal subarachnoid haemorrhage 18 , and ICH 16 . In the present study, the increased periostin levels observed in the first 6 days or within 4 weeks after IS were correlated with the NIHSS scores, indicating that the new accumulation of periostin in the circulation might reflect the degree of IS severity.…”

Section: Discussionmentioning

confidence: 95%

“…In addition, a recent study reported that serum periostin levels were significantly increased in patients with intracerebral haemorrhage (ICH) within 6 h after ICH compared with controls, and its levels were consistently increased within almost 24 h after ICH 16 . It seems that the uptrend of periostin levels is consistent after onset between ischaemic and haemorrhagic stroke, although the rising speed is different.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

Bao

Shen

et al. 2018

Sci Rep

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Increasing evidence supports the involvement of periostin in the pathophysiological processes of stroke and atherosclerosis. The aim of this study was to assess circulating periostin levels at different times after large-artery atherosclerotic (LAA) stroke and their association with stroke. Serum periostin levels were measured using enzyme-linked immunosorbent assay on day 1 in 162 patients with LAA stroke and in 108 age- and sex-matched controls, on day 6 after stroke in 134 patients, and during the 4th week after stroke in 46 of the 162 patients. Stroke severity was determined using the National Institutes of Health Stroke Scale (NIHSS), and the stroke volume was measured. Outcome at 3 months was measured using the modified Rankin Scale (mRS). Our results indicated that periostin levels increased significantly on day 6 after stroke, and this increasing trend persisted for at least 4 weeks after the event. In addition, the increase in periostin levels was positively correlated with the NIHSS scores and stroke volume, but not with the mRS scores after adjusting for the NIHSS scores. In conclusion, these findings suggest that the increase in serum periostin levels observed after stroke may be associated with the stroke severity in patients with LAA stroke.

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“…In patients with severe traumatic brain injury, detection of higher levels of serum periostin at admission predicted 30-day mortality with high sensitivity and high specificity [55]. Serum periostin levels were also measured in acute spontaneous intracerebral hemorrhage patients, in which increased periostin levels correlated well with the hematoma volume and neurological severity [56].…”

Section: Periostin In Various Disordersmentioning

confidence: 99%

The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage

Kanamaru¹,

Kawakita²,

Asada³

et al. 2019

obm neurobiol

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Aneurysmal subarachnoid hemorrhage (aSAH) causes serious brain injury, and its mechanisms have not been completely unraveled so far. The causative factors for the brain injury initiated by an aneurysm rupture, which is referred to as the early brain injury (EBI), include elevated intracranial pressure, cerebral hypoperfusion, and blood contents that are directly exposed to the brain surface. At Day 4-14 post aSAH, delayed cerebral ischemia (DCI) often develops, which may worsen the neurological outcomes critically. DCI may be a consequence of EBI. Understanding the complex mechanisms underlying the post-aSAH brain injury (EBI and DCI) is, therefore, important in order to improve the neurological outcomes. In addition, several biomarkers possibly associated with EBI, DCI, and neurological outcome have been investigated, although none of these has been conclusive. A matricellular protein periostin has emerged as an important potential contributor to EBI and DCI, and may serve as the biomarker and a therapeutic molecular target for EBI and DCI. In the present report, the possible role of periostin in aSAH has been reviewed.

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Association between serum periostin concentrations and outcome after acute spontaneous intracerebral hemorrhage

Cited by 14 publications

References 27 publications

Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage

Association between Non-Alcoholic Fatty Liver Disease and Intracerebral Hemorrhage

Longitudinal evaluation of serum periostin levels in patients after large-artery atherosclerotic stroke: A prospective observational study

The Role of Periostin in Brain Injury Caused by Subarachnoid Hemorrhage

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