Association between Serum Spermidine and TyG Index: Results from a Cross-Sectional Study

Zhang, Rui; Xu, Jiahui; Li, Ruixue; Yu, Zhecong; Yuan, Wei; Gao, Hanshu; Feng, Wenjing; Gu, Cuiying; Sun, Zhaoqing; Zheng, Liqiang

doi:10.3390/nu14183847

Cited by 5 publications

(3 citation statements)

References 28 publications

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“…Therefore, due to the differences in race, gender, study population, and health status, criteria for assessing insulin resistance are often inconsistent, and establishing a universal normal range remains a problem. In previous studies, it is recommended that the upper quartile of insulin resistance (or the lower quartile of insulin sensitivity) of the specific population under a study be used as the cutoff for insulin resistance, regardless of the test method (26)(27)(28). As markers of insulin resistance, the higher the TyG index and HOMA-IR, the higher the level of insulin resistance.…”

Section: Definitionsmentioning

confidence: 99%

Osteocalcin is associated with triglyceride glucose index rather than HOMA-IR in men with type 2 diabetes

Huang

et al. 2022

Front. Endocrinol.

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IntroductionThe involvement of osteocalcin in the regulation of glucose tolerance in humans is controversial. We utilized a novel and practical insulin resistance surrogate, the triglyceride-glucose (TyG) index, to investigate the association between serum osteocalcin and insulin resistance in men with type 2 diabetes (T2D).MethodsThis was a retrospective cross-sectional study that included 667 male patients suffering from T2D, with measurements of N-terminal mid-fragment of osteocalcin (N-MID), triglycerides (TG), fasting blood glucose (FBG) and C-peptide collected on the same day. We used the TyG index and HOMA-IR as surrogate measures for insulin resistance. Binary logistic regression models that adjust the sociodemographic characteristics and metabolism-related factors were used to assess the associations between osteocalcin and insulin resistance. Restricted cubic spline (RCS) analysis was used to test the potential non-linear relationship between N-MID and the risk of severe insulin resistance. Subgroup analysis evaluated the robustness of the association.ResultsN-MID was correlated with the level of insulin resistance when quantified by the TyG index in unadjusted and adjusted binary logistic regression models (all p < 0.05), but the relationship was not observed when assessed by HOMA-IR (all p > 0.05). RCS model further confirmed that the association between N-MID and the severe insulin resistance measured by the TyG index was non-linear (P = 0.047). Subgroup analysis showed that the association was detected only in younger patients with lower BMI and poorer glycemic control, without hypertension or smoking.ConclusionsOsteocalcin was inversely associated with the TyG index in men with T2D.

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Section: Definitionsmentioning

confidence: 99%

Osteocalcin is associated with triglyceride glucose index rather than HOMA-IR in men with type 2 diabetes

Huang

et al. 2022

Front. Endocrinol.

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“…Similar to the findings in animals, spermidine calculated from dietary intake in a general population of National Health and Nutrition Examination Survey (NHANES) from 2009 to 2010 was negatively associated with serum glucose, insulin, HbA1C levels, and homeostatic model assessment of insulin resistance (HOMA-IR) index ( 15 ). Furthermore, our population-based study showed serum spermidine was inversely associated with triglyceride-glucose index and the risk of insulin resistance ( 16 ). However, to our knowledge, the associations between spermidine and T2DM and fasting plasma glucose (FPG) has not been fully explored.…”

Section: Introductionmentioning

confidence: 98%

Non-linear associations of serum spermidine with type 2 diabetes mellitus and fasting plasma glucose: a cross-sectional study

Zhang,

et al. 2024

Front. Nutr.

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BackgroundPrevious animal experiments have demonstrated the potential of spermidine to mitigate glucose intolerance, insulin resistance, and hyperinsulinemia. However, there remains a scarcity of epidemiological evidence supporting these findings. Therefore, we aimed to elucidate the associations of serum spermidine with T2DM and FPG.Materials and methodsThe cross-sectional study was conducted from June to August 2019 in the rural areas of Fuxin County, Liaoning Province, China. A total of 4,437 participants were included in the study. The serum spermidine was detected using high-performance liquid chromatography with a fluorescence detector. FPG was measured using the hexokinase method. T2DM was defined as participants with a FPG level of 7.0 mmol/L or greater, or self-reported diagnosis of diabetes by a doctor. Restricted cubic spline model and piecewise linear regression model were used to explore the associations of serum spermidine with T2DM and FPG, respectively.ResultsThe mean (SD) age of the participants was 59.3 (10.0) years, with 622 out of 4,437 participants being defined as T2DM. The serum spermidine in participants stratified by age and BMI categories was significantly different, with p values of 0.006 and 0.001, respectively. Among all the participants, the association of serum spermidine with T2DM was J-shaped. The log (spermidine) was negatively associated with T2DM (OR = 0.68, 95% CI: 0.52 to 0.92, p = 0.01) below the inflection point, while log (spermidine) was not significantly associated with T2DM (OR = 1.97, 95% CI: 0.93 to 4.15, p = 0.07) above the inflection point. Among the participants without T2DM, the association of serum spermidine with FPG was inverted J-shaped. The log (spermidine) was positively associated with FPG (β = 0.13, 95% CI: 0.05 to 0.21, p = 0.001) below the inflection point, while log (spermidine) was negatively associated with FPG (β = −0.29, 95% CI: −0.42 to −0.16, p < 0.001) above the inflection point.ConclusionIn conclusion, non-linear associations of serum spermidine with T2DM and FPG were found in the cross-sectional study in Chinese rural adults. This provided insights into the use of spermidine for the prevention of T2DM, highlighting the potential role in public health prevention strategies of spermidine.

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“…In addition to HHcy, insulin resistance (IR) was likewise found as one of the main contributors to CVD, 20 which is regarded as an insulin-regulated defect in tissue glucose metabolism control. 21,22 The "gold standard method" for IR assessing is hyperinsulinemic-euglycemic clamp, [23][24][25] and its alternative method was Homeostatic Model Assessment (HOMA-IR) by calculating insulin and glucose levels to determine IR. 26 However, these tests are so expensive and complex to detrimentally restrict their wide use.…”

Section: Introductionmentioning

confidence: 99%

Association of Triglyceride-Glucose Index with the Risk of Hyperhomocysteinemia Among Chinese Male Bus Drivers: A Longitudinal Study

Xiong¹,

Wu²,

Huang³

et al. 2023

IJGM

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Background Insulin resistance (IR) and hyperhomocysteinemia (HHcy) are significant risk factors for cardiovascular disease (CVD). As an important marker for IR, Triglyceride-Glucose (TyG) index maybe a significant predictor for HHcy progression, reflecting cardiovascular risk. However, the relationship between TyG index and HHcy has been unknown, especially for the high-risk occupation group of male bus drivers. This longitudinal study was initially conducted to explore the outcome of TyG index in predicting HHcy among male bus drivers. Methods In total, 1018 Chinese male bus drivers with Hcy data and regular follow-up from 2017 to 2021 were screened, and 523 non-HHcy subjects at baseline were included in the longitudinal cohort. A restricted cubic spline (RCS) was performed to investigate the possible non-linear relationship between TyG index and the progression of HHcy. A multivariate logistic regression model was used to explore the association between TyG index and developing HHcy via assessing the value of odds ratio (OR) and 95% confidence interval (CI). Results After the median follow up time of 2.12 years, approximately 27.7% of male bus drivers (mean age: 48.1 years) was identified as new incidents HHcy. Multivariate logistic regression found that the higher level of TyG was associated with an increased risk of new onset HHcy (OR = 1.47; 95% CI: 1.11–1.94); and the association seemed to be strong among male bus drivers with elevated low-density lipoprotein cholesterol (LDL-C) ( P for interaction < 0.05). Conclusion As a higher risk occupation group for HHcy, male bus drivers should cause much more attentions from policy makers, employers, and health professionals in China. Identifying male bus drivers with HHcy is of significance at an earlier stage in the primary care setting. Being a significant predictive factor for HHcy, TyG index could be used to monitor and prevent Chinese male bus drivers from HHcy, especially for individuals with elevated LDL-C.

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Association between Serum Spermidine and TyG Index: Results from a Cross-Sectional Study

Cited by 5 publications

References 28 publications

Osteocalcin is associated with triglyceride glucose index rather than HOMA-IR in men with type 2 diabetes

Osteocalcin is associated with triglyceride glucose index rather than HOMA-IR in men with type 2 diabetes

Non-linear associations of serum spermidine with type 2 diabetes mellitus and fasting plasma glucose: a cross-sectional study

Association of Triglyceride-Glucose Index with the Risk of Hyperhomocysteinemia Among Chinese Male Bus Drivers: A Longitudinal Study

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