Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Nonobese Postmenopausal Women: A Cross-sectional Study

Bao, Ting; Ying, Zhiye; Gong, L.; Du, Jing; Ji, Guiyi; Li, Zhengzheng; Gao, Wei; Jiang, Xianweng; Yang, Hanwei; Huang, Yan; Tang, Huairong

doi:10.1038/s41598-020-66931-9

Cited by 20 publications

(20 citation statements)

References 37 publications

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“…Incidentally, there have been quite a few cross-sectional and prospective observational studies with Chinese population analyzing serum uric acid and liver health. Bao et al (2020) in their study identified a relationship between serum uric acid level and NAFLD in a population of non-obese post-menopausal women [ 22 ]. Similarly, in another prospective observational study, individuals with elevated serum uric acid levels were found to have a greater potential to develop NAFLD [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

A Population Based Study of Liver Function amongst Adults with Hyperuricemia and Gout in the United States

Deb

Sakharkar

2021

Diseases

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To examine the association between uric acid levels and liver enzyme functions amongst adults with hyperuricemia and gout in the United States. The National Health and Nutrition Examination Survey (NHANES) data from 2007 to 2016 was used to study the research objective. Data were analyzed for descriptive statistics and for differences using the t test, Chi-square test and ANOVA. A regression analysis was performed to determine association between demographics and liver enzymes. A p value of <0.05 or <0.001 was considered statistically significant. A total of 14,946 adults (≥20 yrs.) were included in this study. Sample mean age was 49 ± 0.15 yrs., and 54% were female. Overall, 15% adults had elevated uric acid levels (≥6.8 mg/dL), men had significantly higher uric acid levels than women (6 mg/dL vs. 4.8 mg/dL). High uric acid levels were associated with more than two times higher odds of elevated ALT, AST and GGT (p < 0.001). Similarly, gender-based target uric acid values were associated with two-fold increased odds of GGT, over one-and-a-half fold higher odds of ALT and AST (p < 0.001). Regression analysis showed significant association between age, gender, race/ethnicity, body mass index, and hypertension and ALT, AST, ALP, total bilirubin and GGT (p < 0.001). Adults with hyperuricemia and gout are most likely to develop liver dysfunctions and suffer associated morbidities. Such patients need to be appropriately monitored and managed for their liver functions and to prevent associated morbidities.

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Section: Discussionmentioning

confidence: 99%

A Population Based Study of Liver Function amongst Adults with Hyperuricemia and Gout in the United States

Deb

Sakharkar

2021

Diseases

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“…Another study showed an association between serum GGT and elevated SUA in normotensive Chinese individuals 22 . A recent study showed a significant positive association and dose-dependent relationship between SUA and the prevalence of NAFLD in nonobese postmenopausal population in China 23 . The elevated SUA concentration, even within the normal range also showed an association with increased ALT in Chinese adults 24 .…”

Section: Introductionmentioning

confidence: 97%

Assessment of the relationship between serum uric acid levels and liver enzymes activity in Bangladeshi adults

Molla

Kathak

Sumon

et al. 2021

Sci Rep

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Serum uric acid (SUA) level has been suggested to be associated with cardiovascular disease, diabetes and metabolic syndrome. However, little is known about the relationship between SUA and liver enzymes activity in the general population. The present study aimed to assess the relationship between SUA and serum liver enzymes in an adult population in Bangladesh. In this cross-sectional study, a total of 410 blood samples were collected from apparently healthy adults aged > 18 years. SUA, liver enzymes, lipid profile and other biochemical markers were measured in the collected samples by using standard methods. Multinomial logistic regression model was used to assess the relationship between SUA and elevated levels of liver enzymes among the participants. Overall, the prevalence of hyperuricemia was 30.1% with 32.2% in male and 18.6% in female participants. About 33% of the participants had at least one or more elevated levels of liver enzymes. The mean level of SUA was significantly higher in males (389.3 ± 96.9 µmol/L) than in the female (290.4 ± 89.8 µmol/L) subjects (p < 0.001). There was a significant difference in the mean levels of serum ALT and GGT between the male (34.5 ± 16.0 U/L and 26.7 ± 19.5 U/L, respectively) and female (25.0 ± 13.0 U/L and 19.5 ± 13.2 U/L, respectively) participants (p < 0.001 and p < 0.01, respectively). An increasing trend was observed in the mean levels of serum ALT and GGT across the SUA quartile groups (p < 0.001 and p < 0.01, respectively). SUA showed a positive and significant correlation with serum ALT (p < 0.001) and GGT (p < 0.01). In further statistical analysis after adjustment for potential confounders, SUA showed an independent and significant association with serum ALT and GGT in all regression models. In conclusion, SUA was strongly associated with serum levels of ALT and GGT after adjustment for potential confounders. More prospective studies are needed to clarify the complex relationship between SUA and liver enzymes in the general population.

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“…and performed on 541 type 2 diabetic patients, showed that UA levels were not independently associated with the risk of NAFLD in female population ( 8 ). Another study showed that the presence of UA predicted the risk of NAFLD only in nonobese postmenopausal females, rather than in obese postmenopausal females ( 30 ). However, our study found the positive association of UA and liver steatosis held true for both premenopausal and postmenopausal females, which was consistent with an early study, showing that high levels of UA were associated with NAFLD both in premenopausal and postmenopausal females ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study

Duan

Zhang²,

Chen³

et al. 2022

Front. Endocrinol.

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Background and objectiveSerum uric acid (UA) is related to many metabolic diseases. However, the association of UA with liver diseases was not very clear. The objective of this study is to clarify the relationship of UA with liver steatosis and fibrosis.MethodsThis is a cross-sectional study of 4364 people of National Health and Nutrition Examination Survey (NHANES) 2017-2018. Liver steatosis and fibrosis were assessed by controlled attenuation parameter (CAP) and liver stiffness measurements (LSM) using Vibration-controlled transient elastography (VCTE). Linear and logistic regressions were performed.ResultsAfter adjusting for potential confounders, UA levels were associated with the prevalence of liver steatosis [OR=2.097 (95%CI: 1.245, 3.534)] and liver fibrosis [OR=2.983 (95%CI: 1.797, 4.952)]. Furthermore, the results were consistent in the subgroup analyses of males and females.ConclusionsUA levels were positively associated with the prevalence of liver steatosis and fibrosis.

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Association between Serum Uric Acid and Nonalcoholic Fatty Liver Disease in Nonobese Postmenopausal Women: A Cross-sectional Study

Cited by 20 publications

References 37 publications

A Population Based Study of Liver Function amongst Adults with Hyperuricemia and Gout in the United States

A Population Based Study of Liver Function amongst Adults with Hyperuricemia and Gout in the United States

Assessment of the relationship between serum uric acid levels and liver enzymes activity in Bangladeshi adults

Associations of Uric Acid With Liver Steatosis and Fibrosis Applying Vibration Controlled Transient Elastography in the United States: A Nationwide Cross-Section Study

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