Association Between Serum Uric Acid and Metabolic Syndrome Components in Prep Ubertal Obese Children (Tanner Stage I) At Zagazig University Hospital

IntroductionHyperuricemia commonly associated with Gout has been proposed as an independent risk factor for Metabolic Syndrome (MetS).ObjectiveThe purpose of the study was to determine if there is a relationship between hyperuricemia and MetS.MethodsAn analysis of cross-sectional data was conducted using the 2013–2018 National Health and Nutrition Examination Survey (NHANES) datasets. Sample weights were assigned by NHANES researchers to each participant allowing researchers to generalize results to all non-institutionalized United States (US) civilians. The analysis included 6,432 individuals, which were representative of 94,729,059 US citizens.ResultsPearson’s correlations, chi-square tests, and logistic regression equations were calculated to determine the association between hyperuricemia and MetS. In an unadjusted regression analysis, individuals with hyperuricemia (above 7.0 mg/dL in males and 6.0 mg/dL in females) were 3.19 times more likely to have MetS compared to those with normal uric acid (UA) levels. When controlling for various confounding variables those with hyperuricemia were 1.89 and 1.34 times more likely to have MetS than those with normal UA levels in two additional logistic regression models.ConclusionIn this large cross-sectional study, hyperuricemia was found to be associated with MetS. Additional analyses that controlled for various risk factors previously identified as predictive of MetS still demonstrated hyperuricemia independently associated with MetS. The results of this study suggest a need to understand the metabolic pathways of UA more clearly to further explain the contribution to MetS. Additional research should include prospective clinical trials assessing the effects of UA and the control of UA on MetS and concomitant medical outcomes.

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Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

Bowden

Adair

Richardson³

2022

Front. Med.

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Uric Acid Levels in Overweight and Obese Children, and Their Correlation With Metabolic Risk Factors

AlAteeq,

Almaneea,

Althaqeb

et al. 2024

Cureus

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Association Between Serum Uric Acid and Metabolic Syndrome Components in Prep Ubertal Obese Children (Tanner Stage I) At Zagazig University Hospital

Cited by 2 publications

References 15 publications

Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

Uric acid and metabolic syndrome: Findings from national health and nutrition examination survey

Uric Acid Levels in Overweight and Obese Children, and Their Correlation With Metabolic Risk Factors

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