Association between serum uric acid and triglycerides in Chinese children and adolescents with short stature

Abstract

Background Elevated triglyceride (TG) levels are a biomarker for cardiovascular disease (CVD) risk. The correlation between serum uric acid (SUA) and TG concentrations in adults or obese children is well established. However, studies on SUA and TG in children with short stature are limited. Aim To determine the relationship between SUA and TG levels in short children and adolescents. Method This was a cross-sectional evaluation of a cohort of 1095 patients with short stature (720 males and 375 females). The related clinical characteristics, including anthropometric and biochemical parameters, were determined. Results Smooth curve fitting, adjusted for potential confounders was performed, which indicated the existence of a non-linear relationship between these measures. Piecewise multivariate linear analysis revealed a significant positive relationship between SUA and TG at SUA concentrations over 7 mg/dL (β = 0.13, 95% CI: 0.05–0.22, P = 0.002) but no significant correlation at lower SUA levels (β = 0.01, 95% CI: 0.01–0.04, P = 0.799). Furthermore, a stratified analysis was performed to appraise changes in this relationship for different sexes and standard deviation levels of body mass index (BMI). The non-linear relationship remained consistent in males and females with BMI standard deviation scores (BMI SDS) ≥ 0, with inflection points of 6.71 mg/dL and 3.93 mg/dL, respectively. Within these two groups, SUA and TG levels showed a positive association when SUA levels were higher than the inflection point (β = 0.21, 95% CI: 0.11–0.31, P < 0.001 for males and β = 0.1, 95% CI: 0.03–0.17, P = 0.005 for females). However, a specific relationship was not observed at lower SUA levels. No significant relationships were found between SUA and TG levels in males and females with BMI SDS < 0. Conclusion The present study identified the non-linear association of SUA and TG levels with short children and adolescents. This relationship was based on BMI status. This finding suggests that health status should be considered for short stature children with high SUA levels, especially in children with a high BMI standard deviation score.

Exploration of Blood Lipoprotein and Lipid Fraction Profiles in Healthy Subjects through Integrated Univariate, Multivariate, and Network Analysis Reveals Association of Lipase Activity and Cholesterol Esterification with Sex and Age

“…Many more sex- and age- lipoprotein associations are being discovered [ 5 , 14 , 15 , 16 ]: in the era of precision medicine, understanding how sex and age shape the lipidome can lead to better diagnosis and treatment of conditions that occur more frequently in one of the two sexes, present sex-specific symptoms and outcomes, or are characteristic of a specific age group [ 17 ].…”

Relationship Between Atherogenic Index of Plasma and Serum Uric Acid in Patients With Untreated Essential Hypertension in China: A Cross-Sectional Study

“…18 In addition, studies indicated that high TG could affect kidney function, thereby reducing renal excretion of SUA in the kidney and elevating SUA levels. 33,34 Also, decreased HDL was closely associated with elevated level of SUA. 35 Consequently, elevated AIP (elevated TG/decreased HDL) was positively related to HUA.…”

Using point‐of‐care devices to examine covariation among blood nutritional‐physiological parameters and their relationships with poxvirus infection, habitat urbanization, and male plumage coloration in house finches (Haemorhous mexicanus)

“…Uric acid is a by‐product of amino acid metabolism, such as purines, an important structure for DNA (Yu et al, 1998), which may be used to ameliorate oxidative stress (Klandorf et al, 1999). In children, high levels of serum uric acid were associated wither higher triglyceride levels, and the authors discussed that uric acid promotes lipid peroxidation, and may increase blood‐vessel wall inflammation (Baldwin et al, 2011; Chu et al, 2021). Therefore, we suggest that the underlying mechanism for covariation between uric acid and triglyceride concentrations in house finches might also be stress related.…”