Association Between Serum Uric Acid and Prediabetes in the Korean General Population

Abstract

The purpose of this study is to examine the relation of serum uric acid with prediabetes in Korea. We conducted a cross-sectional study in 4633 individuals aged 20 to 81 years who participated in the 2016 Korean National Health and Nutrition Examination Survey. Participants are considered to have prediabetes if they have one or more of the following: impaired fasting glucose (fasting blood glucose levels between 5.6 and 6.9 mmol/L); impaired hemoglobin A1c (hemoglobin A1c ranges of 5.7% to 6.4% [39-46 mmol/mol]). Multiple logistic regression analysis was used to compute odds ratios (ORs) and 95% confidence intervals (CIs). Prediabetes was more prevalent in the hyperuricemia group compared with the normal-range group among men (OR = 1.51; 95% CI = 1.11-2.05; P < .01) and women (OR = 1.84; 95% CI = 1.01-3.37; P = .04) after adjustment for age, body mass index, abdominal obesity, blood pressure, triglyceride, high-density lipoprotein cholesterol, renal function, alcohol consumption, smoking, and physical activity level. For a standard deviation increment in uric acid, the odds of having prediabetes as compared with that of not having prediabetes increased about 114% in men ( P = .05) and 116% in women ( P = .01). Higher levels of uric acid were associated with an increased risk of prediabetes among the general Korean population.

Association between serum uric acid and fasting plasma glucose level in non-diabetic, pre-diabetic and diabetic adults: a population-based study in China

“…The relationship among SUA, FPG and serum lipid are also deserve to be mentioned. In line with previous studies (31,32), increasing trend at the mean level of TG, TC, and LDL-C were observed across the glycemic statues and SUA quartiles, while HDL-C decreased. Several putative mechanisms may be proposed for the observed results.…”

Inverted U‐shaped associations between serum uric acid and fasting ‐ plasma glucose level in non‐diabetic, pre‐diabetic, and diabetic adults: A population‐based study in China

“…The relationships between SUA, FPG, and serum lipid also deserve to be mentioned. Consistent with previous studies 40,41 , an increasing trend in the mean levels of TG, TC, and LDL-C was observed across the glycemic status and SUA quartiles, while a decreasing trend in HDL-C levels was seen. Several putative mechanisms could be proposed for these findings.…”

Elevated serum uric acid is a risk factor for progression to prediabetes in Japanese women: A 5‐year retrospective chort study

“…Similarly, the 6‐year follow‐up data of the Chinese population indicated a strong positive association between SUA and incident prediabetes in women rather than in men 25 . Furthermore, in the Korean population, the odds of having prediabetes compared with that of not having it increased by 16% in women for an increment of 1 mg/dL in SUA ( P = 0.01); however, the odds were not significant in men ( P = 0.05) 26 . The present study was conducted among a homogeneous Japanese population and confirmed the women‐specific association between SUA and prediabetes.…”