Association Between Serum Uric Acid Level and Components of the Metabolic Syndrome

Lin, Shi-Dou; Tsai, Dai-Hua; Hsu, Shang-Ren

doi:10.1016/s1726-4901(09)70320-x

Cited by 127 publications

(106 citation statements)

References 26 publications

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“…This is in agreement with previous studies, 7,20,37 which have constantly found an independent correlation between triglycerides and UA levels. Confounding factors such as BMI or WC could explain this strong association.…”

Section: Discussionsupporting

confidence: 94%

“…9 K Uric acid correlates significantly with cardiovascular risk factors. 7,32,37 What our study adds to this topic K Sub-Saharan African men have lower uric acid levels compared with Caucasian men from South Africa. K Triglycerides correlated strongly with uric acid in both ethnic groups, but remained significant only in Caucasians after adjustments.…”

Section: Conflict Of Interestmentioning

confidence: 73%

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Uric acid and the cardiovascular profile of African and Caucasian men

2010

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The African population is considered a high-risk group for the development of hypertension, and identifying risk factors are therefore essential in preventive actions against cardiovascular disease (CVD). Elevated levels of uric acid (UA) are often associated with CVD. Our first aim was to establish possible ethnic differences in UA levels between African and Caucasian men. Our second aim was to determine any associations between UA levels and cardio-metabolic variables, and also how these correlates differ between the two groups. African (N ¼ 87) and Caucasian (N ¼ 121) men participated in this cross-sectional study. Our results have shown that African men had significantly lower (353±87.7 vs 401 ± 98.2; Po0.01) UA levels compared with Caucasian men. Waist circumference and triglycerides correlated strongly with UA in both ethnic groups. This was confirmed with a forward stepwise multiple regression analysis. After adjustment for confounders, the correlation between UA and triglycerides remained significant only in the Caucasians (r ¼ 0.29; P ¼ 0.02), whereas only the African men showed an independent correlation between UA and total peripheral resistance (TPR) (r ¼ 0.23; P ¼ 0.04). TPR increased significantly across UA tertiles only in the African men (P ¼ 0.01 vs P ¼ 0.96).In conclusion, despite their lower UA levels, Africans showed an independent relationship between UA and vascular resistance, indicating a possible explanation for their high prevalence of hypertension.

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Section: Discussionsupporting

confidence: 94%

Section: Conflict Of Interestmentioning

confidence: 73%

Uric acid and the cardiovascular profile of African and Caucasian men

2010

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“…In a second study, the prevalence of gout in the U.K. adult population was estimated to be 1.4%, with a peak of more than 7% in men aged over 75 years old (5). This trend has also been observed in studies in developing countries in Asia (6,7). Although the studies focused on gout, it is inferred that hyperuricemia incidence has also increased over the same period.…”

Section: Epidemiology Of Gout and Hyperuricemiamentioning

confidence: 82%

Uric acid transport and disease

Thorens²

2010

J. Clin. Invest.

691

496

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Uric acid is the metabolic end product of purine metabolism in humans. It has antioxidant properties that may be protective but can also be pro-oxidant, depending on its chemical microenvironment. Hyperuricemia predisposes to disease through the formation of urate crystals that cause gout, but hyperuricemia, independent of crystal formation, has also been linked with hypertension, atherosclerosis, insulin resistance, and diabetes. We discuss here the biology of urate metabolism and its role in disease. We also cover the genetics of urate transport, including URAT1, and recent studies identifying SLC2A9, which encodes the glucose transporter family isoform Glut9, as a major determinant of plasma uric acid levels and of gout development.Conflict of interest: Alexander So has acted as a consultant and advisor for Novartis.Citation for this article:

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“…Interestingly, the association was obtained even within the normal range of serum triglycerides. 24 The mechanism for the strong association between triglycerides and uric acid concentrations has not been elucidated.…”

Section: Discussionmentioning

confidence: 99%

Interaction between serum uric acid and triglycerides in relation to blood pressure

et al. 2010

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The aim of this study was to examine the independent relationship between serum uric acid (SUA) and blood pressure, and to assess their joint effects on obesity, fasting glucose and lipids. The study samples were from a community-based health examination survey in Xuzhou, Jiangsu province of China (2009). Blood pressure, body mass index, fasting glucose, lipids and SUA were measured. After excluding individuals with fasting glucose greater than 7 mmol l À1 , a total of 8415 subjects with biomarkers available were included in the present study. Blood pressure increased with elevated SUA levels, after adjusting for age and sex. Further adjustment for fasting glucose, lipids and alcohol consumption did not change the increasing trend. The associations between uric acid and hypertension were most evident in those with highest quintiles of high-density lipoprotein cholesterol (HDL-C). In addition, the associations were significant in both men and women, and we found significant interactions between uric acid status and age on hypertension. When the joint effects were examined, we found an additive effect of triglycerides and uric acid levels on diastolic blood pressure (DBP). There was significant association between SUA and hypertension, independent of other metabolic risk factors. HDL-C levels may modify the associations between uric acid and hypertension. The effects of triglycerides and uric acid levels on DBP were additive.

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Association Between Serum Uric Acid Level and Components of the Metabolic Syndrome

Abstract: Serum UA level was elevated significantly as the number of metabolic components increased. Abnormal TG had the most influence on serum UA. A prospective study is warranted to determine if the prevention or treatment of hyperuricemia affects the development of metabolic syndrome.

Cited by 127 publications

References 26 publications

Uric acid and the cardiovascular profile of African and Caucasian men

Uric acid and the cardiovascular profile of African and Caucasian men

Uric acid transport and disease

Interaction between serum uric acid and triglycerides in relation to blood pressure

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