Association between serum uric acid and cardiovascular mortality and all-cause mortality

Cheong, EunSun; Ryu, Seungho; Lee, Jong‐Young; Lee, Sung Ho; Sung, Joo-Wook; Cho, Dong-Sik; Park, Jeong Bae; Sung, Ki‐Chul

doi:10.1097/hjh.0000000000001330

Cited by 38 publications

(39 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to our findings, a recent study showed no association between uric acid levels and all‐cause or cardiovascular mortality . In that study, uric acid was categorized according to quintiles (≤5.2, 5.3–5.8, 5.9–6.4, 6.5–7.1, and >7.1 mg/dl in men and ≤3.5, 3.6–4.0, 4.1–4.4, 4.5–5.0, and >5.0 mg/dl in women).…”

Section: Discussioncontrasting

confidence: 99%

“…However, the role of uric acid as an independent risk factor for CVD, cancer, and all‐cause mortality remains a subject of controversy . Some studies demonstrated a positive association between hyperuricemia and cardiovascular mortality , while other studies did not . Furthermore, studies of the association between serum uric acid level and cancer mortality have provided conflicting results.…”

mentioning

confidence: 99%

See 1 more Smart Citation

U‐Shaped Association Between Serum Uric Acid Level and Risk of Mortality

Cho

Chang

Kim

et al. 2018

Arthritis & Rheumatology

Self Cite

133

122

View full text Add to dashboard Cite

show abstract

Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

U‐Shaped Association Between Serum Uric Acid Level and Risk of Mortality

Cho

Chang

Kim

et al. 2018

Arthritis & Rheumatology

Self Cite

133

122

View full text Add to dashboard Cite

show abstract

“…Prior studies were mainly focused on patients with specific conditions. Some suggested a J-or U-shaped relationship [9][10][11][12][13][14][15] or a strong positive relationship, while others suggested a null association [16][17][18][19][20][21][22][23] or inverse association [24]. Direct evidence for healthy individuals is limited [44,45].…”

Section: Discussionmentioning

confidence: 99%

Repeated measurements of serum urate and mortality: a prospective cohort study of 152,358 individuals over 8 years of follow-up

Jin

Shu

et al. 2020

Arthritis Res Ther

View full text Add to dashboard Cite

Background: Longitudinal evidence on change of serum urate level with mortality risk is limited as prior studies have a measurement of serum urate at a single time point. Further, the combined effect of serum urate and systemic inflammation on mortality is unknown. Methods: We conducted a prospective cohort study of 152,358 participants (122,045 men and 30,313 women) with repeated measurements of serum urate in 2006, 2008, 2010, and 2012 (107,751 participants had all four measurements of serum urate). We used the Cox proportional hazard model to examine the association between cumulative average and changes in serum urate with mortality. The combined effect of serum urate and systemic inflammation was determined by testing the interaction of serum urate and high-sensitive C-reactive protein (hs-CRP) in relation to mortality risk. Results: During a median follow-up of 8.7 (interquartile range 6.3-9.2) years, we identified 7564 all-cause deaths, 1763 CVD deaths, 1706 cancer deaths, and 1572 other deaths. We observed U-shaped relationships of cumulative average serum urate with all-cause mortality, cardiovascular mortality, and other mortalities. Compared with participants with stable serum urate, those with greater increases in serum urate had a 1.7-fold elevated mortality (hazard ratio (HR) = 1.66, 95% confidence interval (CI) = 1.49-1.84), and those with decreased serum urate had a 2fold elevated mortality risk (HR = 2.14, 95% CI 1.93-2.37). Participants with both hyperuricemia and hs-CRP had 1.6 times higher mortality, compared with those with low serum urate and hs-CRP levels (HR = 1.56, 95% CI 1.37-1.76). Conclusions: We observed a U-shaped relationship of long-term cumulative average serum urate with all-cause mortality, cardiovascular mortality, and other mortalities. Compared with participants with relatively stable serum urate levels, a greater increase or decrease in serum urate was associated with elevated mortality. Participants with both hyperuricemia and high systemic inflammation had the greatest mortality risk compared with those with low serum urate and low hs-CRP levels.

show abstract

“…Further studies have found that elevated level of SUA has been associated with mortality in patients with CAD, whereas other researches did not find any relation between SUA and CAD in the general population. 8,15,16 Hence, the relationship between SUA and CAD is still controversial. And more importantly, we do not know whether the changes of SUA with renal function will affect the relationship between SUA and CAD.…”

Section: Discussionmentioning

confidence: 99%

“…19 In contrast to these observations, others failed to find an association between either all cause or cardiovascular mortality and UA levels in the general population. 8,16,20 So far, there is no consensus about whether hyperuricemia is an independent risk factor for CAD. The present study found the relationship between hyperuricemia and the presence of CAD in nondialysis patients with stage 3-5 CKD with SUA as a continuous variable.…”

Section: Discussionmentioning

confidence: 99%

Association Between the Serum Uric Acid Level and the Severity of Coronary Artery Disease in a Retrospective Study of China Nondialysis CKD Patients

Yang

Lin

Gao

et al. 2020

Metabolic Syndrome and Related Disorders

View full text Add to dashboard Cite

Introduction: Hyperuricemia has been associated with increased cardiovascular events in the general population. However, the role of serum uric acid (SUA) level on the severity of coronary artery stenosis (CAS) in nondialysis chronic kidney disease (CKD) patients is obscure. Methods: We implement a retrospective cohort study of 734 patients diagnosed with stage 3-5 CKD. All selected patients underwent coronary artery angiography. The associations of SUA with the present, and severity of coronary artery disease (CAD) were analyzed. Results: Of these 734 patients, 511 patients had angiographically proven CAD. Compared with non-CAD group, the SUA level in CAD group was much higher (388.00 vs. 363.00 mmol/l, P < 0.01). After adjusting for multiple confounding factors, a multivariate logistic regression analysis demonstrated that SUA was relevant to the presence of CAD when SUA as a continuous variable. However, this relationship was not observed with SUA as a categorical variable. In a subgroup analysis for the CAD group, we found that the rates of severe CAS in the third tertile of SUA (58.6%) was higher than that in the first tertile (41.6%) (P < 0.01). Compared with the first tertile of SUA, the third tertile of SUA was an independent risk factor for severe arterial stenosis (odds ratio, OR,), a pattern that was recapitulated by multivariate logistic regression analysis with SUA as a continuous variable (1.002 [1.000-1.004]). Conclusions: The SUA level may serve as a predictor of the severity of CAS among nondialysis CKD patients with CAD.

show abstract

Association between serum uric acid and cardiovascular mortality and all-cause mortality

Abstract: In the current large relatively healthy population-based observational study, SUA showed no significant association with all-cause and cardiovascular mortality.

Cited by 38 publications

References 29 publications

U‐Shaped Association Between Serum Uric Acid Level and Risk of Mortality

U‐Shaped Association Between Serum Uric Acid Level and Risk of Mortality

Repeated measurements of serum urate and mortality: a prospective cohort study of 152,358 individuals over 8 years of follow-up

Association Between the Serum Uric Acid Level and the Severity of Coronary Artery Disease in a Retrospective Study of China Nondialysis CKD Patients

Contact Info

Product

Resources

About