Association between Serum Uric Acid and Oxidative Stress in Korean Adults

Ok, Eun Jeong; Kim, Ki‐Young; Park, Sat Byul

doi:10.4082/kjfm.17.0034

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…In addition to antioxidant properties, uric acid is known to have pro-oxidant properties by generating ROS such as superoxide anions, an activity that is mediated by activation of nicotinamide adenine dinucleotide phosphate oxidase in adipocytes, as well as vascular smooth muscle and endothelial cells 2 , 30 , 31 . Consistent with previous in vitro findings, serum uric acid levels were reported to be positively associated with markers of oxidative stress levels in clinical settings 13 – 15 . However, such associations might actually reflect an association of XOR-derived ROS with oxidative stress level, since ROS and also uric acid are produced by an XOR-catalyzed reaction 3 , 4 , and plasma XOR activity has been shown to be positively associated with serum uric acid level 10 – 12 .…”

Section: Discussionsupporting

confidence: 90%

“…In in vitro findings, uric acid has been shown to gain antioxidant properties by scavenging ROS, such as singlet oxygen, peroxyl radical, hydroxyl radical, and peroxynitrite 1 , 22 . Furthermore, serum uric acid levels were reported to be positively associated with markers of antioxidant potential in subjects who underwent a health examination 14 , 15 , 23 . However, those associations were not analyzed after adjustment for the activity of XOR, which produces ROS in addition to uric acid 3 , 4 .…”

Section: Discussionmentioning

confidence: 99%

“…Some previous studies conducted in clinical settings have reported an association between uric acid and oxidative stress level 13 – 15 . However, to the best of our knowledge, no investigation of the association of uric acid with oxidative stress level adjustment for XOR activity in humans has been reported.…”

Section: Introductionmentioning

confidence: 96%

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Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry

Kurajoh

Fukumoto

Yoshida

et al. 2021

Sci Rep

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Uric acid has both antioxidant and pro-oxidant properties in vitro by scavenging and production of reactive oxygen species (ROS). This cross-sectional study examined whether uric acid possesses effects on oxidative stress under physiological conditions independent of xanthine oxidoreductase (XOR), which is involved in uric acid and ROS production. Serum uric acid level was measured, while plasma XOR activity was determined using our high-sensitive assay in 192 participants (91 males, 101 females) who underwent health examinations and were not taking an antihyperuricemic agent. For antioxidant potential and oxidative stress level, biological antioxidant potential (BAP) and derivative of reactive oxygen metabolites (d-ROMs) in serum, respectively, were measured. Median uric acid level and plasma XOR activity were 5.6 mg/dL and 26.1 pmol/h/mL, respectively, and BAP and d-ROMs levels were 2112.8 μmol/L and 305.5 Carr U, respectively. Multivariable regression analyses revealed no significant association of serum uric acid level with BAP level, whereas serum uric acid level showed a significant association with d-ROMs level independent of plasma XOR activity (p = 0.045), which was prominent in females (p = 0.036; p for interaction = 0.148). Uric acid might contribute to increased oxidative stress independent of XOR activity by increasing ROS production, without affecting ROS scavenging, especially in females.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry

Kurajoh

Fukumoto

Yoshida

et al. 2021

Sci Rep

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“…al showed that uric acid is an important endogenous antioxidant in the central nervous system [ 53 ]. One Korean study revealed that higher uric acids were related to better antioxidative capacity [ 54 ]. Previous studies also elucidated that poor sleep is related to increased oxidative stress in both animal and human models [ 55 , 56 ].…”

Section: Discussionmentioning

confidence: 99%

Association of sleep quality and sleep duration with serum uric acid levels in adults

Chou

Shen

et al. 2020

PLoS ONE

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Objective To date, the association between sleep duration or sleep quality and hyperuricemia has remained unclear. In addition, sleep duration and quality were not considered concomitantly in previous studies. Thus, this study was aimed toward an examination of the association of sleep duration and quality with uric acid level in a Taiwanese population. Methods A total of 4,555 patients aged ≥18 years were enrolled in this study. The sleep duration was classified into three groups: short (<7 h), normal (7–9 h), and long (≥9 h). The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate sleep quality, and poor sleep quality was defined as a global PSQI score of >5. Results Poor sleepers were younger and had lower body mass index, blood pressure, uric acid, blood sugar, cholesterol, creatinine level, shorter sleep duration, and engaged in less exercise but had a higher white blood cell count and prevalence of smoking as compared to good sleepers. There were also differences in body mass index, blood pressure, uric acid, blood sugar, lipid profiles, and sleep quality among subjects with different sleep durations. After adjusting for other variables, poor sleep quality was associated with lower uric acid levels. In addition, short sleep duration was positively associated with higher uric acid levels. Conclusions Poor sleep quality was related to lower uric acid levels, whereas short sleep duration was associated with higher uric acid levels.

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“…Of late, oxidative stress has been recognised as an important factor in the pathogenesis and development of lifestyle-related diseases. Recent studies have shown that serum uric acid levels are related to the oxidative status, and therefore, may play a role in the antioxidant defence systems [19][20][21].…”

Section: Discussionmentioning

confidence: 99%

How Exercise Can Influence Oxidative Stress and Glucose Levels after Pancreatic Resection: A Randomised Controlled Trial

et al. 2019

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Background: One of the most challenging operations is the resection of the pancreas, which is associated with high morbidity. Metabolic control during the perioperative period remains an issue that is sometimes difficult to manage. Objectives: Exercise has a positive effect on glycaemic control. The objective of this trial was determining whether exercise has any benefit for oxidative stress and glucose levels. Method:The study was an open-label, randomised clinical trial. It has been registered in the International Standard Randomised Controlled Trial registry. The patients were selected according to the Consolidated Standard of Reporting Trials criteria. Results: In total, 56 patients were assessed for eligibility. There was no statistical difference between the 2 groups (the exercise and the control one) regarding the disease characteristics, morbidity or influence of exercise on oxidative stress; however, the control of glucose was superior in the exercise group. Conclusions: Exercise has a positive effect on glycaemic control in patients after pancreatic resection.

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Association between Serum Uric Acid and Oxidative Stress in Korean Adults

Cited by 13 publications

References 16 publications

Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry

Uric acid shown to contribute to increased oxidative stress level independent of xanthine oxidoreductase activity in MedCity21 health examination registry

Association of sleep quality and sleep duration with serum uric acid levels in adults

How Exercise Can Influence Oxidative Stress and Glucose Levels after Pancreatic Resection: A Randomised Controlled Trial

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